Myh14 myosin, heavy polypeptide 14 [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Myh14provided by MGI
Official Full Name: myosin, heavy polypeptide 14provided by MGI
Primary source: MGI:1919210
See related: Ensembl:ENSMUSG00000030739; Vega:OTTMUSG00000017593
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: II-C; NHMCII; NMHC II-C; 2400004E04Rik

Genomic context

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Location :: 7; 7 B2

Sequence :: Chromosome: 7; NC_000073.6 (44605819..44665503, complement)

See Myh14 in Epigenomics, MapViewer

Chromosome 7 - NC_000073.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

NM II-C1C2 may be involved in stabilizing neurites by maintaining their structure at adhesion sites
Title: The effect of including the C2 insert of nonmuscle myosin II-C on neuritogenesis.
Data indicate that when both NM II-C and II-B are ablated the B-C-/B-C- cardiac myocytes show major defects in karyokinesis.
Title: Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis.
This study provides molecular insight into the role of the structurally disordered tailpiece of non-muscle myosin IIC (NMII-C) in shifting the oligomeric equilibrium of NMII-C toward filament assembly and determining its morphology.
Title: The positively charged region of the myosin IIC non-helical tailpiece promotes filament assembly.
myosin II, directly regulates cellular patterning and alignment within the cochlear sensory epithelium
Title: Myosin II regulates extension, growth and patterning in the mammalian cochlear duct.
the alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation
Title: An alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation.
mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C
Title: Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C.
a cGMP-independent mechanism for nitric oxide-mediated inhibition of nonmuscle myosin heavy chain II-C induction
Title: Induction of nonmuscle myosin heavy chain II-C by butyrate in RAW 264.7 mouse macrophages.

Submit: New GeneRIF Correction

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation
Targeted (knock-in) (1)

Pathways from BioSystems

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Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
Regulation of actin cytoskeleton, organism-specific biosystem
Regulation of actin cytoskeleton
Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
Regulation of actin cytoskeleton, conserved biosystem
Regulation of actin cytoskeleton
Sema4D in semaphorin signaling, organism-specific biosystem (from REACTOME)
Sema4D in semaphorin signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Sema4D induced cell migration and growth-cone collapse, organism-specific biosystem (from REACTOME)
Sema4D induced cell migration and growth-cone collapse, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Semaphorin interactions, organism-specific biosystem (from REACTOME)
Semaphorin interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Tight junction, organism-specific biosystem (from KEGG)
Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Tight junction, conserved biosystem (from KEGG)
Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Viral myocarditis, organism-specific biosystem (from KEGG)
Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

General gene information

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Markers

Myh14 (e-PCR), detects polymorphism
- UniSTS:526909

RH136048 (e-PCR)
- UniSTS:210043

Homology

Homologs of the Myh14 gene: The Myh14 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
actin binding	IEA Inferred from Electronic Annotation more info
actin filament binding	IDA Inferred from Direct Assay more info	PubMed
actin-dependent ATPase activity	IDA Inferred from Direct Assay more info	PubMed
calmodulin binding	IEA Inferred from Electronic Annotation more info
microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed
motor activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
ATP catabolic process	IDA Inferred from Direct Assay more info	PubMed
actin filament-based movement	IDA Inferred from Direct Assay more info	PubMed
metabolic process	IDA Inferred from Direct Assay more info	PubMed
regulation of cell shape	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
axon	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
growth cone	IDA Inferred from Direct Assay more info	PubMed
myosin complex	IDA Inferred from Direct Assay more info	PubMed
stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myosin-14

Names: myosin-14; myosin heavy chain 14; myosin, heavy chain 14; nonmuscle myosin heavy chain; non-muscle myosin heavy chain IIc; myosin heavy chain, non-muscle IIc

NP_082297.1

EC 3.6.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271538.1 → NP_001258467.1 myosin-14 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC150895, AC157653

UniProtKB/Swiss-Prot

Q6URW6

Conserved Domains (3) summary

cd01377
Location:97 – 836
Blast Score: 2953

MYSc_type_II; Myosin motor domain, type II myosins. Myosin II mediates cortical contraction in cell motility, and is the motor in smooth and skeletal muscle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins ...

pfam01576
Location:1132 – 1984
Blast Score: 600

Myosin_tail_1; Myosin tail

smart00242
Location:96 – 837
Blast Score: 2472

MYSc; Myosin. Large ATPases.
NM_001271540.1 → NP_001258469.1 myosin-14 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AC150895, AC157653

UniProtKB/Swiss-Prot

Q6URW6

Conserved Domains (3) summary

cd01377
Location:97 – 803
Blast Score: 2987

MYSc_type_II; Myosin motor domain, type II myosins. Myosin II mediates cortical contraction in cell motility, and is the motor in smooth and skeletal muscle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins ...

pfam01576
Location:1099 – 1951
Blast Score: 594

Myosin_tail_1; Myosin tail

smart00242
Location:96 – 804
Blast Score: 2518

MYSc; Myosin. Large ATPases.
NM_028021.3 → NP_082297.1 myosin-14 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AC150895, AC157653

Consensus CDS

CCDS39943.1

UniProtKB/Swiss-Prot

Q6URW6

Related

ENSMUSP00000103531, OTTMUSP00000019210, ENSMUST00000107899, OTTMUST00000042769

Conserved Domains (3) summary

cd01377
Location:97 – 795
Blast Score: 2990

MYSc_type_II; Myosin motor domain, type II myosins. Myosin II mediates cortical contraction in cell motility, and is the motor in smooth and skeletal muscle. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins ...

pfam01576
Location:1091 – 1943
Blast Score: 592

Myosin_tail_1; Myosin tail

smart00242
Location:96 – 796
Blast Score: 2525

MYSc; Myosin. Large ATPases.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000073.6 Reference GRCm38.p1 C57BL/6J

Range

44605819..44665503, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000029.1 Alternate Mm_Celera

Range

40055770..40115661, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01061129.1 (32950..92841)	None
genomic	AC150895.2 (99703..116490)	None
genomic	AC157653.2	None
genomic	CH466603.1	EDL22740.1	mixed
		EDL22741.1	mixed
mRNA	AK010278.1	None	C57BL/6J
mRNA	AY205605.1	AAO47092.1	C57BL/6
mRNA	AY363100.1	AAQ24173.1	C57BL/6
mRNA	BC040821.1	None	FVB/N
mRNA	BC041796.1	AAH41796.1	FVB/N
mRNA	BC054465.1	AAH54465.1	FVB/N
mRNA	EF602040.1	ABR10605.1