Nanog Nanog homeobox [Mus musculus] - Gene

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Summary

Official Symbol: Nanogprovided by MGI
Official Full Name: Nanog homeoboxprovided by MGI
Primary source: MGI:1919200
See related: Ensembl:ENSMUSG00000012396; Vega:OTTMUSG00000023511
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ENK; ecat4; 2410002E02Rik

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Genomic context

Location :: 6 F2; 6

Sequence :: Chromosome: 6; NC_000072.6 (122707568..122713778)

See Nanog in Epigenomics, MapViewer

Chromosome 6 - NC_000072.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

tight regulation of Nanog dose at the chromosome level is necessary for the acquisition of ground-state pluripotency during development
Title: Control of ground-state pluripotency by allelic regulation of Nanog.
these data show that Nanog is expressed during surgically induced marrow bone formation and is functionally involved in post natal marrow stromal cell maintenance and differentiation.
Title: Role of Nanog in the maintenance of marrow stromal stem cells during post natal bone regeneration.
Ezh2 directly regulates the epigenetic status of the Nanog promoter affecting the balance of Nanog expression in pluripotent stem cells, and therefore the equilibrium between self-renewal and differentiation.
Title: Epigenetic regulation of Nanog expression by Ezh2 in pluripotent stem cells.
Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells
Title: Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells.
in Nanog null embryos, Gata6 expression is maintained, showing that initiation of the primitive endoderm program is Nanog independent
Title: Primitive endoderm differentiates via a three-step mechanism involving Nanog and RTK signaling.
Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain.
Title: Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain.
NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation
Title: NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation.
Geminin antagonizes the chromatin-remodeling protein Brg1 to maintain expression of Oct4, Sox2, and Nanog. The results define a pluripotency pathway by which suppressed anaphase-promoting complex/cyclosome activity protects geminin from degradation in G1.
Title: Geminin escapes degradation in G1 of mouse pluripotent cells and mediates the expression of Oct4, Sox2, and Nanog.
the mechanism by which Pten null embryonic stem cells emerge in vitro and cause tumors in vivo is through increased survival and self-renewal, due to failed repression of the transcription factor Nanog.
Title: Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog.
It was shown that 2i/LIF treatment in clonal lines of pre-iPS cells results in the activation of endogenous Nanog and rapid downregulation of retroviral Oct4 expression.
Title: Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions.

Submit: New GeneRIF Correction See all (91)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Reporter) (3) 1 citation
Gene trapped (2)
Targeted (knock-in) (1) 1 citation

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Products	Interactant	Other Gene	Source	Pubs	Description
NT_094510.1	NP_032236.1	H3f3a	BIND	PubMed	Acetylated histone 3 (H3) interacts with the Nanog promoter.
NT_094510.1	NP_035770.1	Trp53	BIND	PubMed	p53 interacts the Nanog promoter.
NT_094510.1			BIND	PubMed	p53-mSin3a complex interacts with the Nanog promoter.
BioGRID:215050	BioGRID:230549	Ahctf1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:215050	BioGRID:204938	Esrrb	BioGRID	PubMed	Affinity Capture-MS
BioGRID:215050	BioGRID:199692	Foxm1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:215050	BioGRID:231518	Gatad2a	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:215050	BioGRID:230858	Gatad2b	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:215050	BioGRID:241423	Hdac1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:215050	BioGRID:200260	Hdac2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:215050	BioGRID:212438	Ilf2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:215050	BioGRID:221360	Kdm1a	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:215050	BioGRID:201332	Mbd3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:215050	BioGRID:228045	Mta1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:215050	BioGRID:204807	Mta2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:215050	BioGRID:201999	Mybbp1a	BioGRID	PubMed	Affinity Capture-MS
BioGRID:215050	BioGRID:211748	Nacc1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:215050	BioGRID:198035	Nr0b1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:215050	BioGRID:211812	Pbrm1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:215050	BioGRID:204839	Pin1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:215050	BioGRID:202265	Pml	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:215050	BioGRID:202313	Pou5f1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:215050	BioGRID:232827	Rbbp7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:215050	BioGRID:202864	Rest	BioGRID	PubMed	Affinity Capture-MS
BioGRID:215050	BioGRID:206234	Rif1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:215050	BioGRID:208384	Sall1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:215050	BioGRID:221236	Sall4	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:215050	BioGRID:203256	Sin3a	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:215050	BioGRID:211982	Smarca2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:215050	BioGRID:203336	Smarca4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:215050	BioGRID:203406	Sox2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:215050	BioGRID:203414	Sp1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:215050	BioGRID:204197	Trim28	BioGRID	PubMed	Affinity Capture-MS
BioGRID:215050	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:215050	BioGRID:230082	Wapal	BioGRID	PubMed	Affinity Capture-MS
BioGRID:215050	BioGRID:230516	Zfp281	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:215050	BioGRID:217903	Zmym2	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
DNA binding	ISO Inferred from Sequence Orthology more info
chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enhancer sequence-specific DNA binding	IDA Inferred from Direct Assay more info
protein binding	IPI Inferred from Physical Interaction more info
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	ISO Inferred from Sequence Orthology more info
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info

Process	Evidence Code	Pubs
cell proliferation	ISO Inferred from Sequence Orthology more info
embryo development	IMP Inferred from Mutant Phenotype more info	PubMed
endodermal cell fate specification	ISO Inferred from Sequence Orthology more info
mesodermal cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell fate commitment	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell fate commitment	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of endodermal cell fate specification	TAS Traceable Author Statement more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IGI Inferred from Genetic Interaction more info	PubMed
positive regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info
positive regulation of transcription from RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
positive regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info
regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
regulation of gene expression	ISO Inferred from Sequence Orthology more info
regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
response to chemical stimulus	IDA Inferred from Direct Assay more info	PubMed
response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed
somatic stem cell maintenance	ISO Inferred from Sequence Orthology more info
stem cell differentiation	IDA Inferred from Direct Assay more info
stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
stem cell division	IDA Inferred from Direct Assay more info	PubMed
stem cell maintenance	IDA Inferred from Direct Assay more info	PubMed
stem cell maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
nucleolus	ISO Inferred from Sequence Orthology more info
nucleoplasm	IDA Inferred from Direct Assay more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
soluble fraction	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: homeobox protein NANOG

Names: homeobox protein NANOG; ES cell-associated protein 4; homeobox transcription factor Nanog; early embryo specific expression NK family; early embryo specific expression NK-type homeobox protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028016.2 → NP_082292.1 homeobox protein NANOG

Status: PROVISIONAL

Source sequence(s)

BC132017

Consensus CDS

CCDS39623.1

UniProtKB/TrEMBL

A2RS90

UniProtKB/Swiss-Prot

Q80Z64

Related

ENSMUSP00000012540, OTTMUSP00000027613, ENSMUST00000012540, OTTMUST00000057270

Conserved Domains (1) summary

cd00086
Location:98 – 155
Blast Score: 171

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000072.6 Reference GRCm38 C57BL/6J

Range

122707568..122713778

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000028.1 Alternate Mm_Celera

Range

124507792..124514310

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC131715.3 (37090..44228)	None
genomic	CH466523.1	EDK99694.1	mixed
genomic	CQ860376.1	CAH25963.1
genomic	DQ358089.1	ABD16123.1	129/Ola
genomic	DQ358090.1	ABD16124.1	129/Sv
mRNA	AB093574.1	BAC76998.1
mRNA	AB126939.1	BAD72892.1
mRNA	AF507043.1	AAO67362.1	FVB
mRNA	AK010332.1	BAE43219.1	C57BL/6J
mRNA	AK167259.1	None	C57BL/6J
mRNA	AY278951.1	AAP92157.1	129/Ola
mRNA	AY455282.1	AAS57554.1	C57BL/6
mRNA	AY455285.1	AAS57556.1	C57BL/6
mRNA	BC083105.1	None	C57BL/6
mRNA	BC132017.1	AAI32018.1
mRNA	BC137873.1	AAI37874.1
mRNA	BC144995.1	AAI44996.1
mRNA	BC144996.1	AAI44997.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q0QJG6	GenPept	UniProtKB/TrEMBL:Q0QJG6
Q5TM83.1	GenPept	UniProtKB/Swiss-Prot:Q5TM83
Q80Z64.1	GenPept	UniProtKB/Swiss-Prot:Q80Z64