Zswim2 zinc finger, SWIM domain containing 2 [Mus musculus] - Gene

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Summary

Official Symbol: Zswim2provided by MGI
Official Full Name: zinc finger, SWIM domain containing 2provided by MGI
Primary source: MGI:1919111
Locus tag: RP23-141N19.5
See related: Ensembl:ENSMUSG00000034552; Vega:OTTMUSG00000013389
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MEX; 1700025P14Rik; 4933437F18Rik

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Genomic context

Location :: 2; 2 E1

Sequence :: Chromosome: 2; NC_000068.7 (83915079..83941226, complement)

See Zswim2 in Epigenomics, MapViewer

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

MEX(identical to Zswim2) has homology to MEKK1 & is expressed uniquely in testis. MEX has 4 putative zinc-binding domains including an N-terminal SWIM (SWI2/SNF2 & MuDR) domain of unknown function & 2 RING fingers separated by ZZ zinc finger domain
Title: MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis.

Submit: New GeneRIF Correction

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Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:214986	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:214986	BioGRID:113169	UBE2D1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:214986	BioGRID:214986	Zswim2	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
ligase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein self-association	IDA Inferred from Direct Assay more info	PubMed
ubiquitin-protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
apoptotic process	IEA Inferred from Electronic Annotation more info
metabolic process	IEA Inferred from Electronic Annotation more info
protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info

General protein information

Preferred Names: E3 ubiquitin-protein ligase Zswim2

Names: E3 ubiquitin-protein ligase Zswim2; MEKK1-related protein X; ZZ-type zinc finger-containing protein 2; zinc finger SWIM domain-containing protein 2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027964.2 → NP_082240.1 E3 ubiquitin-protein ligase Zswim2

Status: PROVISIONAL

Source sequence(s)

AK006367

Consensus CDS

CCDS16183.1

UniProtKB/TrEMBL

Q0VB10

UniProtKB/Swiss-Prot

Q9D9X6

Related

ENSMUSP00000044913, OTTMUSP00000014369, ENSMUST00000038223, OTTMUST00000032354

Conserved Domains (5) summary

cd00162
Location:343 – 389
Blast Score: 107

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cd02338
Location:233 – 271
Blast Score: 126

ZZ_PCMF_like; Zinc finger, ZZ type. Zinc finger present in potassium channel modulatory factor (PCMF) 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Human potassium channel ...

pfam13923
Location:342 – 387
Blast Score: 79

zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

cl15348
Location:145 – 202
Blast Score: 84

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

cl15408
Location:54 – 86
Blast Score: 90

SWIM; SWIM zinc finger

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38 C57BL/6J

Range

83915079..83941226, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000024.1 Alternate Mm_Celera

Range

85573761..85599958, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AL772256.15	CAM15050.1
		CAQ51720.1
genomic	CH466519.1	EDL27278.1	mixed
		EDL27279.1	mixed
mRNA	AK006367.1	BAB24549.1	C57BL/6J
mRNA	AK017097.1	None	C57BL/6J
mRNA	BC120837.1	AAI20838.1
mRNA	BC144860.1	None
mRNA	EU233996.1	None