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Map3k13 mitogen-activated protein kinase kinase kinase 13 [ Mus musculus (house mouse) ]

Gene ID: 71751, updated on 8-May-2016
Official Symbol
Map3k13provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 13provided by MGI
Primary source
MGI:MGI:2444243
See related
Ensembl:ENSMUSG00000033618
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LZK; C130026N12Rik
Orthologs
Location:
16; 16 B1
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 16 NC_000082.6 (21825171..21933439)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (21892042..21931950)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase Neighboring gene RIKEN cDNA 1300002E11 gene Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene predicted gene, 36455 Neighboring gene predicted gene, 26744 Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene transmembrane protein 41a Neighboring gene lipase, member H

  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystem
    Insulin Signaling
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
JNK cascade ISO
Inferred from Sequence Orthology
more info
 
activation of MAPKK activity ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with IkappaB kinase complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
mitogen-activated protein kinase kinase kinase 13
Names
mitogen activated protein kinase kinase kinase 13
NP_766409.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172821.3NP_766409.2  mitogen-activated protein kinase kinase kinase 13

    See identical proteins and their annotated locations for NP_766409.2

    Status: VALIDATED

    Source sequence(s)
    AK047986, AK054039, BB455895, BB549158, BP761466, CX240141, DQ480427
    Consensus CDS
    CCDS37294.1
    UniProtKB/Swiss-Prot
    Q1HKZ5
    Related
    ENSMUSP00000047388, ENSMUST00000042065
    Conserved Domains (2) summary
    smart00221
    Location:167401
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:173409
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p3 C57BL/6J

    Range
    21825171..21933439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522583.2XP_006522646.1  

    See identical proteins and their annotated locations for XP_006522646.1

    UniProtKB/Swiss-Prot
    Q1HKZ5
    Conserved Domains (2) summary
    smart00221
    Location:167401
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:173409
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  2. XM_006522582.2XP_006522645.1  

    See identical proteins and their annotated locations for XP_006522645.1

    UniProtKB/Swiss-Prot
    Q1HKZ5
    Conserved Domains (2) summary
    smart00221
    Location:167401
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:173409
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  3. XM_011246016.1XP_011244318.1  

    See identical proteins and their annotated locations for XP_011244318.1

    UniProtKB/Swiss-Prot
    Q1HKZ5
    Conserved Domains (2) summary
    smart00221
    Location:167401
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:173409
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  4. XM_011246015.1XP_011244317.1  

    See identical proteins and their annotated locations for XP_011244317.1

    UniProtKB/Swiss-Prot
    Q1HKZ5
    Conserved Domains (2) summary
    smart00221
    Location:167401
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:173409
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
  5. XM_006522584.2XP_006522647.1  

    See identical proteins and their annotated locations for XP_006522647.1

    UniProtKB/Swiss-Prot
    Q1HKZ5
    Conserved Domains (2) summary
    smart00221
    Location:167401
    STYKc; Protein kinase; unclassified specificity
    cd14059
    Location:173409
    STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

Alternate Mm_Celera

Genomic

  1. AC_000038.1 Alternate Mm_Celera

    Range
    22459094..22498899
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)