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Cul2 cullin 2 [ Mus musculus (house mouse) ]

Gene ID: 71745, updated on 28-May-2016
Official Symbol
Cul2provided by MGI
Official Full Name
cullin 2provided by MGI
Primary source
MGI:MGI:1918995
See related
Ensembl:ENSMUSG00000024231 Vega:OTTMUSG00000034308
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI327301; mKIAA4106; 1300003D18Rik; 4932411N15Rik
Orthologs
Location:
18; 18 A1
Exon count:
23
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 18 NC_000084.6 (3382975..3436700)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (3383223..3436698)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor, 238 Neighboring gene cAMP responsive element modulator Neighboring gene predicted gene 6225 Neighboring gene profilin 1 pseudogene Neighboring gene BMP and activin membrane-bound inhibitor

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA4106

Gene Ontology Provided by MGI

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Cul2-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
VCB complex ISO
Inferred from Sequence Orthology
more info
 
cullin-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029402.3NP_083678.2  cullin-2

    See identical proteins and their annotated locations for NP_083678.2

    Status: VALIDATED

    Source sequence(s)
    AC124336, AK004875, AK144693, AK162910
    Consensus CDS
    CCDS29032.2
    UniProtKB/Swiss-Prot
    Q9D4H8
    Related
    ENSMUSP00000125403, OTTMUSP00000047342, ENSMUST00000162301, OTTMUST00000087267
    Conserved Domains (3) summary
    smart00182
    Location:424568
    CULLIN; Cullin
    pfam00888
    Location:14645
    Cullin; Cullin family
    pfam10557
    Location:672739
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p3 C57BL/6J

    Range
    3382975..3436700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526274.2XP_006526337.1  

    See identical proteins and their annotated locations for XP_006526337.1

    UniProtKB/Swiss-Prot
    Q9D4H8
    Related
    ENSMUSP00000025073, OTTMUSP00000047343, ENSMUST00000025073, OTTMUST00000087268
    Conserved Domains (3) summary
    smart00182
    Location:424568
    CULLIN; Cullin
    pfam00888
    Location:14645
    Cullin; Cullin family
    pfam10557
    Location:672739
    Cullin_Nedd8; Cullin protein neddylation domain
  2. XM_006526275.2XP_006526338.1  

    See identical proteins and their annotated locations for XP_006526338.1

    UniProtKB/Swiss-Prot
    Q9D4H8
    Conserved Domains (3) summary
    smart00182
    Location:424568
    CULLIN; Cullin
    pfam00888
    Location:14645
    Cullin; Cullin family
    pfam10557
    Location:672739
    Cullin_Nedd8; Cullin protein neddylation domain

Alternate Mm_Celera

Genomic

  1. AC_000040.1 Alternate Mm_Celera

    Range
    3432713..3487378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)