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TPM3 tropomyosin 3 [ Homo sapiens (human) ]

Gene ID: 7170, updated on 26-Aug-2014
Official Symbol
TPM3provided by HGNC
Official Full Name
tropomyosin 3provided by HGNC
Primary source
HGNC:12012
Locus tag
RP11-205M9.1
See related
Ensembl:ENSG00000143549; HPRD:01840; MIM:191030; Vega:OTTHUMG00000035853
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TM3; TM5; TRK; CFTD; NEM1; TM-5; TM30; CAPM1; TM30nm; TPMsk3; hscp30; HEL-189; HEL-S-82p; OK/SW-cl.5
Summary
This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
See TPM3 in Epigenomics, MapViewer
Location:
1q21.2
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (154155304..154192135, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154127780..154164611, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene nucleoporin 210kDa-like Neighboring gene ribosomal protein S7 pseudogene 2 Neighboring gene microRNA 5698 Neighboring gene microRNA 190b Neighboring gene chromosome 1 open reading frame 189

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Exposure of human skin fibroblasts to HIV-1 protease induces the degradation of the vimentin filament network and the disappearance of the tropomyosin isoforms microfilament network PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
    Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Cardiac muscle contraction, conserved biosystem (from KEGG)
    Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
    Smooth Muscle Contraction, organism-specific biosystemLayers of smooth muscle cells can be found in the walls of numerous organs and tissues within the body. Smooth muscle tissue lacks the striated banding pattern characteristic of skeletal and cardiac ...
  • Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
    Striated Muscle Contraction, organism-specific biosystemMuscle contraction is the process where muscle tissue is activated by a signal from the nervous system. In case of voluntary action the nervous signals are initiated from the brain by so called actio...
  • Striated Muscle Contraction, organism-specific biosystem (from REACTOME)
    Striated Muscle Contraction, organism-specific biosystemStriated muscle contraction is a process whereby force is generated within striated muscle tissue, resulting in a change in muscle geometry, or in short, increased force being exerted on the tendons....
  • Thyroid cancer, organism-specific biosystem (from KEGG)
    Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
  • Thyroid cancer, conserved biosystem (from KEGG)
    Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC3261, FLJ41118, MGC14582, MGC72094

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
cellular component movement TAS
Traceable Author Statement
more info
PubMed 
muscle contraction TAS
Traceable Author Statement
more info
 
muscle filament sliding TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cleavage furrow IEA
Inferred from Electronic Annotation
more info
 
cortical cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
filamentous actin IEA
Inferred from Electronic Annotation
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
muscle thin filament tropomyosin TAS
Traceable Author Statement
more info
PubMed 
podosome IEA
Inferred from Electronic Annotation
more info
 
stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tropomyosin alpha-3 chain
Names
tropomyosin alpha-3 chain
tropomyosin-5
tropomyosin gamma
cytoskeletal tropomyosin TM30
epididymis luminal protein 189
alpha-tropomyosin, slow skeletal
heat-stable cytoskeletal protein 30 kDa
epididymis secretory sperm binding protein Li 82p

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008621.1 

    Range
    4999..41830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001043351.1NP_001036816.1  tropomyosin alpha-3 chain isoform 4

    See proteins identical to NP_001036816.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon and contains an alternate exon in the central coding region, but maintains the reading frame, compared to variant 2. The encoded isoform (4, also known as Tm5NM2) is the same length as isoform 2 but differs in the sequence.
    Source sequence(s)
    AA863064, AL537561, AL590431, BC000771, DA472065
    Consensus CDS
    CCDS41400.1
    UniProtKB/Swiss-Prot
    P06753
    Conserved Domains (3) summary
    pfam00261
    Location:12248
    Blast Score: 576
    Tropomyosin; Tropomyosin
    pfam06009
    Location:150229
    Blast Score: 81
    Laminin_II; Laminin Domain II
    cl19113
    Location:7117
    Blast Score: 141
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  2. NM_001043352.1NP_001036817.1  tropomyosin alpha-3 chain isoform 3

    See proteins identical to NP_001036817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 2. The encoded isoform (3, also known as Tm5NM7 or TC22), is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AA863064, AK123113, AL590431, AY004867, BM674269, DA472065
    Consensus CDS
    CCDS41402.1
    UniProtKB/Swiss-Prot
    P06753
    Conserved Domains (2) summary
    pfam00261
    Location:12245
    Blast Score: 565
    Tropomyosin; Tropomyosin
    cl19113
    Location:7117
    Blast Score: 144
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  3. NM_001043353.1NP_001036818.1  tropomyosin alpha-3 chain isoform 5

    See proteins identical to NP_001036818.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an exon and contains an alternate exon in the central coding region, and uses an alternate splice site in the 3' coding region, compared to variant 2. The encoded isoform (5, also known as Tm5NM4) is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AA863064, AK123113, AL590431, BG706843, BI546300, BM674269, BX419658, DA472065
    Consensus CDS
    CCDS41401.1
    UniProtKB/Swiss-Prot
    P06753
    Conserved Domains (2) summary
    pfam00261
    Location:12245
    Blast Score: 577
    Tropomyosin; Tropomyosin
    cl19113
    Location:7117
    Blast Score: 141
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  4. NM_001278188.1NP_001265117.1  tropomyosin alpha-3 chain isoform 6

    See proteins identical to NP_001265117.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon in the 5' coding region, compared to variant 2, and initiates translation at an alternate upstream start codon. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AA863064, AK298678, AL590431, DA472065
    UniProtKB/TrEMBL
    B4DQ80
    Conserved Domains (1) summary
    pfam00261
    Location:22182
    Blast Score: 420
    Tropomyosin; Tropomyosin
  5. NM_001278189.1NP_001265118.1  tropomyosin alpha-3 chain isoform 7

    See proteins identical to NP_001265118.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 2. The encoded isoform (7, also known as Tm5NM5) is the same length as isoform 2 but has a distinct C-terminus.
    Source sequence(s)
    AA863064, AF474157, AL590431, DA472065
    Consensus CDS
    CCDS60275.1
    UniProtKB/Swiss-Prot
    P06753
    Conserved Domains (2) summary
    pfam00261
    Location:12248
    Blast Score: 592
    Tropomyosin; Tropomyosin
    cl19113
    Location:7117
    Blast Score: 143
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  6. NM_001278190.1NP_001265119.1  tropomyosin alpha-3 chain isoform 8

    See proteins identical to NP_001265119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate exon in the central coding region, but maintains the reading frame, compared to variant 2. The encoded isoform (8) is shorter than isoform 2.
    Source sequence(s)
    AA863064, AL590431, BQ933569, DA472065
    Consensus CDS
    CCDS72922.1
    Related
    ENSP00000480520, ENST00000611659
    Conserved Domains (2) summary
    pfam00261
    Location:12227
    Blast Score: 477
    Tropomyosin; Tropomyosin
    cl19113
    Location:7117
    Blast Score: 144
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  7. NM_001278191.1NP_001265120.1  tropomyosin alpha-3 chain isoform 9

    See proteins identical to NP_001265120.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 2. It initiates translation at a downstream in-frame start codon. The encoded isoform (9) is shorter than isoform 2.
    Source sequence(s)
    AA863064, AL590431, BC000771, BF967161, DA209890
    Consensus CDS
    CCDS60274.1
    UniProtKB/Swiss-Prot
    P06753
    Conserved Domains (2) summary
    pfam00261
    Location:1158
    Blast Score: 400
    Tropomyosin; Tropomyosin
    pfam06009
    Location:60139
    Blast Score: 83
    Laminin_II; Laminin Domain II
  8. NM_152263.3NP_689476.2  tropomyosin alpha-3 chain isoform 1

    See proteins identical to NP_689476.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' and 3' UTRs and contains multiple differences in the coding region, compared to variant 2. It represents use of an alternate promoter and initiates translation at an alternate start codon. The encoded isoform (1, also known as alpha s Tm) is longer and has distinct N- and C- termini, compared to isoform 1.
    Source sequence(s)
    AJ573307, AL590431, BC008425, BC050470, DA900740
    Consensus CDS
    CCDS41403.1
    UniProtKB/Swiss-Prot
    P06753
    Conserved Domains (2) summary
    pfam00261
    Location:49285
    Blast Score: 584
    Tropomyosin; Tropomyosin
    pfam12718
    Location:8154
    Blast Score: 234
    Tropomyosin_1; Tropomyosin like
  9. NM_153649.3NP_705935.1  tropomyosin alpha-3 chain isoform 2

    See proteins identical to NP_705935.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes isoform 2 (also known as Tm5NM1, TM-5, or TM30nm).
    Source sequence(s)
    AA863064, AL590431, BC000771, DA472065
    Consensus CDS
    CCDS1060.1
    UniProtKB/Swiss-Prot
    P06753
    Related
    ENSP00000357521, OTTHUMP00000034019, ENST00000368533, OTTHUMT00000087274
    Conserved Domains (2) summary
    pfam00261
    Location:12248
    Blast Score: 564
    Tropomyosin; Tropomyosin
    cl19113
    Location:7117
    Blast Score: 142
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RNA

  1. NR_103460.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) represents use of an alternate promoter and does not share any exons with variant 2, but shares exons with variant 1. This variant is represented as non-coding because use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA429717, BC008425, BM674651, DA900740
  2. NR_103461.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses an alternate splice site at an internal exon, compared to variant 2. This variant is represented as non-coding because use of the 5'-most translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA863064, AL590431, BC000771, BU956481, DA472065

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    154155304..154192135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711519.1XP_006711582.1  

    See proteins identical to XP_006711582.1

    Conserved Domains (3) summary
    pfam00261
    Location:49285
    Blast Score: 557
    Tropomyosin; Tropomyosin
    pfam06009
    Location:187266
    Blast Score: 79
    Laminin_II; Laminin Domain II
    pfam12718
    Location:8154
    Blast Score: 234
    Tropomyosin_1; Tropomyosin like
  2. XM_006711515.1XP_006711578.1  

    See proteins identical to XP_006711578.1

    UniProtKB/TrEMBL
    J3KN67
    Conserved Domains (2) summary
    pfam00261
    Location:49285
    Blast Score: 534
    Tropomyosin; Tropomyosin
    pfam12718
    Location:8154
    Blast Score: 234
    Tropomyosin_1; Tropomyosin like
  3. XM_006711518.1XP_006711581.1  

    See proteins identical to XP_006711581.1

    Conserved Domains (2) summary
    pfam00261
    Location:49285
    Blast Score: 561
    Tropomyosin; Tropomyosin
    pfam12718
    Location:8154
    Blast Score: 234
    Tropomyosin_1; Tropomyosin like
  4. XM_006711521.1XP_006711584.1  

    See proteins identical to XP_006711584.1

    Conserved Domains (2) summary
    pfam00261
    Location:49282
    Blast Score: 555
    Tropomyosin; Tropomyosin
    pfam12718
    Location:8154
    Blast Score: 234
    Tropomyosin_1; Tropomyosin like
  5. XM_006711520.1XP_006711583.1  

    See proteins identical to XP_006711583.1

    Conserved Domains (2) summary
    pfam00261
    Location:49282
    Blast Score: 535
    Tropomyosin; Tropomyosin
    pfam12718
    Location:8154
    Blast Score: 234
    Tropomyosin_1; Tropomyosin like
  6. XM_006711517.1XP_006711580.1  

    See proteins identical to XP_006711580.1

    Conserved Domains (2) summary
    pfam00261
    Location:49285
    Blast Score: 561
    Tropomyosin; Tropomyosin
    pfam12718
    Location:8154
    Blast Score: 234
    Tropomyosin_1; Tropomyosin like
  7. XM_006711522.1XP_006711585.1  

    See proteins identical to XP_006711585.1

    UniProtKB/Swiss-Prot
    P06753
    Conserved Domains (2) summary
    pfam00261
    Location:12248
    Blast Score: 592
    Tropomyosin; Tropomyosin
    cl19113
    Location:7117
    Blast Score: 143
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  8. XM_006711516.1XP_006711579.1  

    See proteins identical to XP_006711579.1

    Conserved Domains (2) summary
    pfam00261
    Location:49285
    Blast Score: 563
    Tropomyosin; Tropomyosin
    pfam12718
    Location:8154
    Blast Score: 234
    Tropomyosin_1; Tropomyosin like
  9. XM_006711523.1XP_006711586.1  

    See proteins identical to XP_006711586.1

    Conserved Domains (2) summary
    pfam00261
    Location:12248
    Blast Score: 603
    Tropomyosin; Tropomyosin
    cl19113
    Location:7117
    Blast Score: 141
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    125491124..125527939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    155524124..155560933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)