Format

Send to:

Choose Destination

TPD52 tumor protein D52 [ Homo sapiens (human) ]

Gene ID: 7163, updated on 8-May-2016
Official Symbol
TPD52provided by HGNC
Official Full Name
tumor protein D52provided by HGNC
Primary source
HGNC:HGNC:12005
See related
Ensembl:ENSG00000076554 HPRD:04963; MIM:604068; Vega:OTTHUMG00000164565
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D52; N8L; PC-1; PrLZ; hD52
Orthologs
Location:
8q21.13
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (80034868..80171659, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (80947103..81083836, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927040 Neighboring gene long intergenic non-protein coding RNA 1607 Neighboring gene RNA, U7 small nuclear 85 pseudogene Neighboring gene uncharacterized LOC105375917 Neighboring gene mitochondrial ribosomal protein S28 Neighboring gene uncharacterized LOC105375919 Neighboring gene uncharacterized LOC105375918 Neighboring gene uncharacterized LOC105375920 Neighboring gene microRNA 5708

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
NHGRI GWA Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
NHGRI GWA Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
NHGRI GWA Catalog
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
NHGRI GWA Catalog
  • Clathrin derived vesicle budding, organism-specific biosystem (from REACTOME)
    Clathrin derived vesicle budding, organism-specific biosystemThere at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the cl...
  • Golgi Associated Vesicle Biogenesis, organism-specific biosystem (from REACTOME)
    Golgi Associated Vesicle Biogenesis, organism-specific biosystemProteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell ...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
  • trans-Golgi Network Vesicle Budding, organism-specific biosystem (from REACTOME)
    trans-Golgi Network Vesicle Budding, organism-specific biosystemAfter passing through the Golgi complex, secretory cargo is packaged into post-Golgi transport intermediates (post-Golgi), which translocate plus-end directed along microtubules to the plasma membran...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: MRPS28

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
B cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
anatomical structure morphogenesis TAS
Traceable Author Statement
more info
PubMed 
secretion TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tumor protein D52
Names
prostate and colon associated protein
prostate leucine zipper
protein N8
NP_001020423.1
NP_001020424.1
NP_001274069.1
NP_001274071.1
NP_001274072.1
NP_001274073.1
NP_005070.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025252.2NP_001020423.1  tumor protein D52 isoform 1

    See identical proteins and their annotated locations for NP_001020423.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks two alternate in-frame exons in the central coding region, compared to variant 4, resulting in an isoform (1, also known as PrLZ-224) that is shorter than isoform 4.
    Source sequence(s)
    BU071387, CB128067, DA079836, DC383362, GQ499327, U18914
    Consensus CDS
    CCDS34912.1
    UniProtKB/Swiss-Prot
    P55327
    Related
    ENSP00000368391, OTTHUMP00000227115, ENST00000379097, OTTHUMT00000379539
    Conserved Domains (1) summary
    pfam04201
    Location:47211
    TPD52; tumor protein D52 family
  2. NM_001025253.2NP_001020424.1  tumor protein D52 isoform 2

    See identical proteins and their annotated locations for NP_001020424.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, compared to variant 4. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 4.
    Source sequence(s)
    AK295468, BU071387, CB128067, DA079836, DC331087, U18914
    Consensus CDS
    CCDS47879.1
    UniProtKB/Swiss-Prot
    P55327
    Related
    ENSP00000429915, OTTHUMP00000226985, ENST00000518937, OTTHUMT00000379269
    Conserved Domains (1) summary
    pfam04201
    Location:7194
    TPD52; tumor protein D52 family
  3. NM_001287140.1NP_001274069.1  tumor protein D52 isoform 4

    See identical proteins and their annotated locations for NP_001274069.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4, also known as PrLZ-247).
    Source sequence(s)
    BU071387, CB128067, DA079836, DC383362, GQ499324, U18914
    Consensus CDS
    CCDS75759.1
    UniProtKB/Swiss-Prot
    P55327
    Related
    ENSP00000429309, OTTHUMP00000227031, ENST00000520527, OTTHUMT00000379381
    Conserved Domains (1) summary
    pfam04201
    Location:47234
    TPD52; tumor protein D52 family
  4. NM_001287142.1NP_001274071.1  tumor protein D52 isoform 5

    See identical proteins and their annotated locations for NP_001274071.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in the central coding region, compared to variant 4, resulting in an isoform (5, also known as PrLZ-238) that is shorter than isoform 4.
    Source sequence(s)
    BU071387, CB128067, DA079836, DC383362, GQ499325, U18914
    Consensus CDS
    CCDS75757.1
    UniProtKB/Swiss-Prot
    P55327
    Related
    ENSP00000410222, ENST00000448733
    Conserved Domains (1) summary
    pfam04201
    Location:47225
    TPD52; tumor protein D52 family
  5. NM_001287143.1NP_001274072.1  tumor protein D52 isoform 6

    See identical proteins and their annotated locations for NP_001274072.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon in the central coding region, compared to variant 4, resulting in an isoform (6, also known as PrLZ-233) that is shorter than isoform 4.
    Source sequence(s)
    BU071387, CB128067, DA079836, DC383362, GQ499326, U18914
    Consensus CDS
    CCDS75758.1
    UniProtKB/Swiss-Prot
    P55327
    Related
    ENSP00000429351, OTTHUMP00000227032, ENST00000517427, OTTHUMT00000379382
    Conserved Domains (1) summary
    pfam04201
    Location:47220
    TPD52; tumor protein D52 family
  6. NM_001287144.1NP_001274073.1  tumor protein D52 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, it lacks two alternate in-frame exons in the central coding region, and it uses an alternate splice site that results in an early stop codon, compared to variant 4. The encoded isoform (7) has a distinct N-terminus and is shorter than isoform 4.
    Source sequence(s)
    BU071387, CB128067, DA079836, DA409017, DC331087, U18914
    UniProtKB/Swiss-Prot
    P55327
    Conserved Domains (1) summary
    pfam04201
    Location:7143
    TPD52; tumor protein D52 family
  7. NM_005079.3NP_005070.1  tumor protein D52 isoform 3

    See identical proteins and their annotated locations for NP_005070.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon and it thus differs in its 5' UTR and 5' coding region, and it lacks two alternate in-frame exons in the central coding region, compared to variant 4. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 4.
    Source sequence(s)
    BU071387, CB128067, DA079836, DC331087, U18914
    Consensus CDS
    CCDS55249.1
    UniProtKB/Swiss-Prot
    P55327
    Related
    ENSP00000368390, OTTHUMP00000227030, ENST00000379096, OTTHUMT00000379380
    Conserved Domains (1) summary
    pfam04201
    Location:7171
    TPD52; tumor protein D52 family

RNA

  1. NR_105033.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) includes an additional exon in the central region, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 4, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BU071387, CB128067, DA079836, DC383362, GQ499328, U18914
  2. NR_105034.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) contains an alternate 5' terminal exon and lacks three internal exons, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BU071387, CB128067, DA079836, DB505575, DC331087, U18914
  3. NR_105035.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) contains alternate 5' exon structure and lacks two internal exons, compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BU071387, CB128067, DA079836, DA199944, DC331087, U18914
  4. NR_105036.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) contains an alternate 5' terminal exon, compared to variant 4. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK308983, BU071387, CB128067, DA079836, DA665049, U18914
  5. NR_105037.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) contains alternate 5' exon structure and lacks two internal exons, compared to variant 4. This variant is represented as non-coding because it lacks a supported open reading frame.
    Source sequence(s)
    BU071387, CB128067, DA079836, DA665049, DA921955, U18914

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    80034868..80171659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    80999297..81135995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)