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    TP73 tumor protein p73 [ Homo sapiens (human) ]

    Gene ID: 7161, updated on 14-May-2013
    Official Symbol
    TP73provided by HGNC
    Official Full Name
    tumor protein p73provided by HGNC
    Primary source
    HGNC:12003
    See related
    Ensembl:ENSG00000078900; HPRD:03587; MIM:601990; Vega:OTTHUMG00000000610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P73
    Summary
    This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
    Location :
    1p36.3
    Sequence :
    Chromosome: 1; NC_000001.10 (3569129..3652765)
    See TP73 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene tumor protein p63 regulated 1-like Neighboring gene WD repeat containing, antisense to TP73 Neighboring gene uncharacterized LOC100506635 Neighboring gene TP73 antisense RNA 1 Neighboring gene coiled-coil domain containing 27 Neighboring gene small integral membrane protein 1

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Transcription factor KLLN inhibits tumor growth by AR suppression, induces apoptosis by TP53/TP73 stimulation in prostate carcinomas, and correlates with cellular differentiation. Wang Y, et al. J Clin Endocrinol Metab, 2013 Mar. PMID 23386643.
    2. Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements. Ethayathulla AS, et al. J Biol Chem, 2013 Feb 15. PMID 23243311.
    3. Effects of carbon-ion beam or X-ray irradiation on anti-apoptosis ΔNp73 expression in HeLa cells. Di CX, et al. Gene, 2013 Feb 15. PMID 23228853.
    4. Methylation alterations at imprinted genes detected among long-term shiftworkers. Jacobs DI, et al. Environ Mol Mutagen, 2013 Mar. PMID 23193016.
    5. Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis. Zorić A, et al. Carcinogenesis, 2013 Mar. PMID 23188674.

    See all (446) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements
      Title: Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements.
    2. KLLN is a transcription factor directly regulating AR, TP53, and TP73 expression, with a role in prostate carcinogenesis.
      Title: Transcription factor KLLN inhibits tumor growth by AR suppression, induces apoptosis by TP53/TP73 stimulation in prostate carcinomas, and correlates with cellular differentiation.
    3. All p53 isoforms counteract TAp73beta transactivation function but with different efficiency and in a promoter-dependent manner.
      Title: Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis.
    4. Novel but opposing roles for the p53 and TAp73 in the induction of Noxa and Bim and regulation of apoptosis.
      Title: N-(phosphonacetyl)-L-aspartate induces TAp73-dependent apoptosis by modulating multiple Bcl-2 proteins: potential for cancer therapy.
    5. The strongest evidence for altered methylation patterns in shiftworkers was observed for TP73 gene.
      Title: Methylation alterations at imprinted genes detected among long-term shiftworkers.
    6. study concludes p73 methylation is common in patients with myelodysplastic synd and is associated with poor prognosis
      Title: Methylation of the p73 gene in patients with myelodysplastic syndromes: correlations with apoptosis and prognosis.
    7. results suggest that the p73 G4C14-to-A4T14 dinucleotide polymorphism may play a role in the development of chronic hepatitis B virus-infected hepatocellular carcinoma in the Chinese population, especially among women
      Title: Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of hepatocellular carcinoma in a Chinese population.
    8. there is a differential DeltaNp73 expression in response to different LET radiations, and down-regulated DeltaNp73 expression might play a critical role in promoting cycle arrest and apoptosis in cancer cells.
      Title: Effects of carbon-ion beam or X-ray irradiation on anti-apoptosis ΔNp73 expression in HeLa cells.
    9. The overexpression of c-Jun, p73 and Casp-9 in thymic epithelial tumors is closely related with the pathogenesis and biological behavior of the neoplasms.
      Title: Expression of c-Jun, p73, Casp9, and N-ras in thymic epithelial tumors: relationship with the current WHO classification systems.
    10. p53 inactivation upregulates p73 expression through E2F-1 mediated transcription
      Title: p53 inactivation upregulates p73 expression through E2F-1 mediated transcription.
    Submit: New GeneRIF Correction See all (346)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Tat, p14 tat In the absence of either p53 or p73, Tat fails to induce dendritic retraction or to activate the proapoptotic proteins, such as Bax PubMed
    tat HIV-1 Tat activates the p53 transcription factor pathway leading to the induction of endogenous p53 and p73 in neuronal cells PubMed
    tat Association of tumor protein p73 with HIV-1 Tat prevents the acetylation of Tat on lysine 28 by PCAF, and requires the cysteine-rich domain (amino acids 30 to 40) of Tat, which binds to the N-terminal region (amino acids 1 to 120) of p73 PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    BAB87244.1 NP_751919.1 HCVgp1    BIND  PubMed HCV core protein interacts with p73 
    BAB87244.1 NP_005418.1 TP73    BIND  PubMed p73 splicing variants interact with each other. 
    BAB87245.1 NP_751919.1 HCVgp1    BIND  PubMed HCV core protein interacts with p73 
    CAA72219.1 NC_000006.9 CDKN1A    BIND  PubMed p73-beta interacts with p21 promoter. This interaction was modeled on a demonstrated interaction between p73-beta from an unspecified species and human p21 promoter. 
    CAA72219.1 NP_751919.1 HCVgp1    BIND  PubMed HCV core protein interacts with p73. 
    CAA72219.1 NP_002119.1 HMGB1    BIND  PubMed p73-beta interacts with HMGB1. 
    CAA72219.1 NP_006212.1 PIN1    BIND  PubMed Pin1 interacts with p73-beta. 
    NP_005418.1 NC_000019.8 BAX    BIND  PubMed p73-alpha interacts with BAX promoter. 
    NP_005418.1 NT_033899.7 BIRC3    BIND  PubMed p73-alpha binds p53 AIP1 promoter. 
    NP_005418.1 NC_000006.9 CDKN1A    BIND  PubMed p73-alpha interacts with p21 promoter. 
    NP_005418.1 NP_005839.1 DENND4A    BIND  PubMed p73 alpha interacts with c-Myc. 
    NP_005418.1 NP_001420.1 EP300    BIND  PubMed p73-alpha interacts with p300.This interaction was modeled on a demonstrated interaction between human p73-alpha and p300 from an unspecified species. 
    NP_005418.1 NP_006089.1 GNB2L1    BIND  PubMed RACK1 interacts with p73. 
    NP_005418.1 NP_751919.1 HCVgp1    BIND  PubMed HCV core protein interacts with p73. 
    NP_005418.1 NP_002119.1 HMGB1    BIND  PubMed p73alpha interacts with HMGB1. 
    NP_005418.1 NP_113671.3 ITCH    BIND  PubMed p73-alpha interacts with Itch. 
    NP_005418.1 NEDD4    BIND  PubMed p73-alpha interacts with an unspecified isoform of Nedd4. 
    NP_005418.1 PFDN5    BIND  PubMed MM1 interacts with p73-alpha. 
    NP_005418.1 NP_006212.1 PIN1    BIND  PubMed Pin1 interacts with phosphorylated p73-alpha 
    NP_005418.1 NT_033899.7 TP53AIP1    BIND  PubMed p73-alpha interacts with p53AIP1 promoter. 
    NP_005418.1 CAA72219.1 TP73    BIND  PubMed p73 splicing variants interact with each other. 
    NP_005418.1 NP_005418.1 TP73    BIND  PubMed p73 alpha interacts with itself. 
    NP_005418.1 NP_006097.1 YAP1    BIND  PubMed p73-alpha interacts with YAP. 
    O15350 P00519 ABL1    HPRD  PubMed  
    O15350 O00499 BIN1    HPRD  PubMed  
    O15350 Q8TDN4 CABLES1    HPRD  PubMed  
    O15350 P06493 CDK1    HPRD  PubMed  
    O15350 P24941 CDK2    HPRD  PubMed  
    O15350 Q03701 CEBPZ    HPRD  PubMed  
    O15350 Q12873 CHD3    HPRD  PubMed  
    O15350 Q92793 CREBBP    HPRD  PubMed  
    O15350 Q9UER7 DAXX    HPRD  PubMed  
    O15350 Q09472 EP300    HPRD  PubMed  
    O15350 P63244 GNB2L1    HPRD  PubMed  
    O15350 Q9P2P5 HECW2    HPRD  PubMed  
    O15350 Q9H2X6 HIPK2    HPRD  PubMed  
    O15350 P09429 HMGB1    HPRD  PubMed  
    O15350 P01112 HRAS    HPRD  PubMed  
    O15350 Q96J02 ITCH    HPRD  PubMed  
    O15350 Q92831 KAT2B    HPRD  PubMed  
    O15350 P45983 MAPK8    HPRD  PubMed  
    O15350 Q00987 MDM2    HPRD  PubMed  
    O15350 O15151 MDM4    HPRD  PubMed  
    O15350 P01106 MYC    HPRD  PubMed  
    O15350 P46934 NEDD4    HPRD  PubMed  
    O15350 P25208 NFYB    HPRD  PubMed  
    O15350 Q99471 PFDN5    HPRD  PubMed  
    O15350 O75925 PIAS1    HPRD  PubMed  
    O15350 P29590 PML    HPRD  PubMed  
    O15350 Q96KQ4 PPP1R13B    HPRD  PubMed  
    O15350 Q15796 SMAD2    HPRD  PubMed  
    O15350 P84022 SMAD3    HPRD  PubMed  
    O15350 P04637 TP53    HPRD  PubMed  
    O15350 Q9H3D4 TP63    HPRD  PubMed  
    O15350 O15350 TP73    HPRD  PubMed  
    O15350 P19544 WT1    HPRD  PubMed  
    O15350 Q9NZC7 WWOX    HPRD  PubMed  
    O15350 P46937 YAP1    HPRD  PubMed  
    BioGRID:113014 BioGRID:106543 ABL1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113014 BioGRID:106640 ADH5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:122932 AGBL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:117726 AGO1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:118041 AGO2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:106696 AHCY    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:113818 AKAP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:106770 AMPH    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:113014 BioGRID:117368 ASF1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:129236 ASPM    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:112666 AURKA    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113014 BioGRID:116641 AZI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:116108 BRD8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:107166 BUB1B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113014 BioGRID:119569 C22orf28    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:127543 C6orf165    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:107340 CCNG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:107427 CDC20    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:123555 CDT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:115455 CEBPZ    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113014 BioGRID:107532 CHD3    BioGRID  PubMed Two-hybrid 
    BioGRID:113014 BioGRID:107569 CHUK    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113014 BioGRID:107777 CREBBP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113014 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:127478 DAB2IP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:107985 DAXX    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113014 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:114811 DDX23    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:115360 DNAJB6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:108135 DPH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Co-purification; Reconstituted Complex 
    BioGRID:113014 BioGRID:128358 FBXO45    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:113014 BioGRID:108892 GAS8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:115671 GNB2L1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113014 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113014 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:121581 HECW2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113014 BioGRID:118815 HIPK2    BioGRID  PubMed Two-hybrid 
    BioGRID:113014 BioGRID:115420 HIPK3    BioGRID  PubMed Two-hybrid 
    BioGRID:113014 BioGRID:109389 HMGB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:113014 BioGRID:109545 HSPA9    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:113014 BioGRID:115886 IGF2BP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:109767 IKBKB    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; FRET 
    BioGRID:113014 BioGRID:123747 ITCH    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113014 BioGRID:121191 JPH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:113014 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:116667 KDM1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:534783 LOC613037    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:115432 LRPPRC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:110260 MAD2L1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113014 BioGRID:110359 MDM4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113014 BioGRID:122289 MTHFSD    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113014 BioGRID:115670 MYL9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:120848 N4BP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:110811 NEDD4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:110815 NEDD8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:110867 NFYB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:110868 NFYC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:113796 NPRL3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:111114 PAX6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:111317 PIN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:114690 PIWIL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:111553 PRKACA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:115359 RANBP9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:113014 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:115301 RBX1    BioGRID  PubMed Biochemical Activity 
    BioGRID:113014 BioGRID:117406 RCHY1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:113014 BioGRID:127416 RNF38    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:127880 SASS6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:112487 SMARCD2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:123158 SPSB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:115564 STAG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:113188 SUMO1    BioGRID  PubMed Two-hybrid 
    BioGRID:113014 BioGRID:112855 TDG    BioGRID  PubMed Two-hybrid 
    BioGRID:113014 BioGRID:115485 TNK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:113011 TP53BP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:113014 BioGRID:113014 TP73    BioGRID  PubMed Two-hybrid 
    BioGRID:113014 BioGRID:113023 TPM3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:121957 TRAPPC11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:121918 TRMT11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:116721 TTLL5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:113014 BioGRID:113177 UBE2I    BioGRID  PubMed Two-hybrid 
    BioGRID:113014 BioGRID:115566 UBE4B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:113014 BioGRID:115684 YAP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligand...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • DNA damage response (only ATM dependent), organism-specific biosystem (from WikiPathways)
      DNA damage response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
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    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
      SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TP53 network, organism-specific biosystem (from WikiPathways)
      TP53 network, organism-specific biosystemP53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high le...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    p53 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    activation of MAPK activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle arrest IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to UV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    cerebrospinal fluid secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    digestive tract morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    hippocampus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    intrinsic apoptotic signaling pathway in response to DNA damage TAS
    Traceable Author Statement
    more info
    		 PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    kidney development IEA
    Inferred from Electronic Annotation
    more info
    		  
    mismatch repair TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitotic G1 DNA damage checkpoint IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    negative regulation of JUN kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    negative regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    neuron development IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    release of cytochrome c from mitochondria IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    response to X-ray IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    response to gamma radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    response to organic nitrogen IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Preferred Names
    tumor protein p73
    Names
    tumor protein p73
    p53-related protein
    p53-like transcription factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017035.2 RefSeqGene

      Range
      5001..88637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001126240.2 → NP_001119712.1  tumor protein p73 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b, also known as deltaN p73 alpha) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AB055065, AI094238, AL136528
      Consensus CDS
      CCDS44049.1
      UniProtKB/Swiss-Prot
      O15350
      Related
      ENSP00000367537, OTTHUMP00000003478, ENST00000378288, OTTHUMT00000009531
      Conserved Domains (4) summary
      pfam07710
      Location:297 – 337
      Blast Score: 108
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:78 – 257
      Blast Score: 745
      P53; P53 DNA-binding domain
      cd09571
      Location:438 – 502
      Blast Score: 358
      SAM_tumor-p73; SAM domain of tumor-p73 proteins
      pfam07647
      Location:436 – 500
      Blast Score: 152
      SAM_2; SAM domain (Sterile alpha motif)

    2. NM_001126241.2 → NP_001119713.1  tumor protein p73 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (c, also known as deltaN p73 beta) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AB055066, AI094238, AL136528
      Consensus CDS
      CCDS44050.1
      UniProtKB/Swiss-Prot
      O15350
      Conserved Domains (2) summary
      pfam07710
      Location:297 – 337
      Blast Score: 111
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:78 – 257
      Blast Score: 738
      P53; P53 DNA-binding domain

    3. NM_001126242.2 → NP_001119714.1  tumor protein p73 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (d, also known as deltaN p73 gamma) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI094238, AL136528, AY040829
      Consensus CDS
      CCDS44051.1
      UniProtKB/Swiss-Prot
      O15350
      Conserved Domains (2) summary
      pfam07710
      Location:297 – 337
      Blast Score: 107
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:78 – 257
      Blast Score: 732
      P53; P53 DNA-binding domain

    4. NM_001204184.1 → NP_001191113.1  tumor protein p73 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (h, also known as TA p73 beta) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AB055066, AI094238, AL136528, Y11416
      Consensus CDS
      CCDS55566.1
      UniProtKB/Swiss-Prot
      O15350
      Conserved Domains (2) summary
      pfam07710
      Location:346 – 386
      Blast Score: 111
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:127 – 306
      Blast Score: 743
      P53; P53 DNA-binding domain

    5. NM_001204185.1 → NP_001191114.1  tumor protein p73 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (i, also known as TA p73 gamma) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI094238, AL136528, AY040829, Y11416
      UniProtKB/Swiss-Prot
      O15350
      Conserved Domains (2) summary
      pfam07710
      Location:346 – 386
      Blast Score: 108
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:127 – 306
      Blast Score: 738
      P53; P53 DNA-binding domain

    6. NM_001204186.1 → NP_001191115.1  tumor protein p73 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks three alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (j, also known as TA p73 delta) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI094238, AL136528, Y11416
      UniProtKB/Swiss-Prot
      O15350
      Conserved Domains (2) summary
      pfam07710
      Location:346 – 386
      Blast Score: 108
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:127 – 306
      Blast Score: 744
      P53; P53 DNA-binding domain

    7. NM_001204187.1 → NP_001191116.1  tumor protein p73 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks two alternate coding exons compared to variant 1, one that causes a frameshift and the other that corrects the frameshift. The resulting isoform (k, also known as TA p73 epsilon) has a shorter and distinct internal segment compared to isoform a.
      Source sequence(s)
      AI094238, AL136528, Y11416
      Consensus CDS
      CCDS55567.1
      UniProtKB/TrEMBL
      C9J521
      Conserved Domains (3) summary
      pfam07710
      Location:346 – 386
      Blast Score: 106
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:127 – 306
      Blast Score: 749
      P53; P53 DNA-binding domain
      cl15755
      Location:446 – 470
      Blast Score: 140
      SAM_superfamily; SAM (Sterile alpha motif )

    8. NM_001204188.1 → NP_001191117.1  tumor protein p73 isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) lacks two alternate coding exons compared to variant 1. The resulting isoform (l, also known as TA p73 zeta) lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AI094238, AL136528, Y11416
      Consensus CDS
      CCDS55568.1
      UniProtKB/Swiss-Prot
      O15350
      Conserved Domains (4) summary
      pfam07710
      Location:346 – 386
      Blast Score: 106
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:127 – 306
      Blast Score: 749
      P53; P53 DNA-binding domain
      pfam07647
      Location:400 – 453
      Blast Score: 132
      SAM_2; SAM domain (Sterile alpha motif)
      cl15755
      Location:400 – 455
      Blast Score: 315
      SAM_superfamily; SAM (Sterile alpha motif )

    9. NM_001204189.1 → NP_001191118.1  tumor protein p73 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks three alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (3, also known as deltaN p73 delta) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AB055065, AI094238, AL136528
      UniProtKB/Swiss-Prot
      O15350
      Conserved Domains (2) summary
      pfam07710
      Location:297 – 337
      Blast Score: 107
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:78 – 257
      Blast Score: 738
      P53; P53 DNA-binding domain

    10. NM_001204190.1 → NP_001191119.1  tumor protein p73 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks two alternate coding exons compared to variant 1, one that causes a frameshift and the other that corrects the frameshift. The resulting isoform (f, also known as deltaN p73 epsilon) has a shorter and distinct N-terminus and a shorter and distinct internal segment compared to isoform a.
      Source sequence(s)
      AB055065, AI094238, AL136528
      UniProtKB/Swiss-Prot
      O15350
      Conserved Domains (3) summary
      pfam07710
      Location:297 – 337
      Blast Score: 105
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:78 – 257
      Blast Score: 746
      P53; P53 DNA-binding domain
      cl15755
      Location:397 – 421
      Blast Score: 140
      SAM_superfamily; SAM (Sterile alpha motif )

    11. NM_001204191.1 → NP_001191120.1  tumor protein p73 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks two alternate coding exons compared to variant 1. The resulting isoform (g, also known as deltaN p73 zeta) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AB055065, AI094238, AL136528
      UniProtKB/Swiss-Prot
      O15350
      Conserved Domains (4) summary
      pfam07710
      Location:297 – 337
      Blast Score: 106
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:78 – 257
      Blast Score: 745
      P53; P53 DNA-binding domain
      pfam07647
      Location:351 – 404
      Blast Score: 132
      SAM_2; SAM domain (Sterile alpha motif)
      cl15755
      Location:351 – 406
      Blast Score: 315
      SAM_superfamily; SAM (Sterile alpha motif )

    12. NM_001204192.1 → NP_001191121.1  tumor protein p73 isoform m

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (m) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AI094238, AK302118, AK310432, AL136528
      Consensus CDS
      CCDS55569.1
      UniProtKB/Swiss-Prot
      O15350
      Conserved Domains (4) summary
      pfam07710
      Location:275 – 315
      Blast Score: 108
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:56 – 235
      Blast Score: 743
      P53; P53 DNA-binding domain
      cd09571
      Location:416 – 480
      Blast Score: 358
      SAM_tumor-p73; SAM domain of tumor-p73 proteins
      pfam07647
      Location:414 – 478
      Blast Score: 153
      SAM_2; SAM domain (Sterile alpha motif)

    13. NM_005427.3 → NP_005418.1  tumor protein p73 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), encodes isoform a, also known as TA p73 alpha.
      Source sequence(s)
      AI094238, AL136528, Y11416
      Consensus CDS
      CCDS49.1
      UniProtKB/Swiss-Prot
      O15350
      Related
      ENSP00000367545, OTTHUMP00000000662, ENST00000378295, OTTHUMT00000001468
      Conserved Domains (4) summary
      pfam07710
      Location:346 – 386
      Blast Score: 109
      P53_tetramer; P53 tetramerisation motif
      cd08367
      Location:127 – 306
      Blast Score: 748
      P53; P53 DNA-binding domain
      cd09571
      Location:487 – 551
      Blast Score: 359
      SAM_tumor-p73; SAM domain of tumor-p73 proteins
      pfam07647
      Location:485 – 549
      Blast Score: 152
      SAM_2; SAM domain (Sterile alpha motif)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      3569129..3652765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      2864839..2947956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      3582688..3665884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic AB031234.1 None
    genomic ABBA01073653.1 (58573..67766) None
    genomic ABBA01073654.1 None
    genomic ABBA01073655.1 None
    genomic AF077616.1 AAC61887.1
    genomic AF077618.1 AAC61887.1
    genomic AF077619.1 AAC61887.1
    genomic AF077620.1 AAC61887.1
    genomic AF077621.1 AAC61887.1
    genomic AF077625.1 AAC61887.1
    genomic AF077626.1 AAC61887.1
    genomic AF077627.1 AAC61887.1
    genomic AF077628.1 AAC61887.1
    genomic AF079082.1 AAD39696.1
    genomic AF079083.1 AAD39696.1
    genomic AF079084.1 AAD39696.1
    genomic AF079085.1 AAD39696.1
    genomic AF079086.1 AAD39696.1
    genomic AF079087.1 AAD39696.1
    genomic AF079088.1 AAD39696.1
    genomic AF079089.1 AAD39696.1
    genomic AF079090.1 AAD39696.1
    genomic AF079091.1 AAD39696.1
    genomic AF079092.1 AAD39696.1
    genomic AF079093.1 AAD39696.1
    genomic AF079094.1 AAD39696.1
    genomic AF235000.1 None
    genomic AL136528.11 (33029..116665) None
    genomic AMYH01000192.1 (26941..110137) None
    genomic CH471130.1 EAW71463.1
      EAW71464.1
      EAW71465.1
      EAW71466.1
      EAW71467.1
      EAW71468.1
    mRNA AB055065.1 BAB87244.1
    mRNA AB055066.1 BAB87245.1
    mRNA AI094238.1 None
    mRNA AK295669.1 BAH12150.1
    mRNA AK302118.1 BAH13630.1
    mRNA AK304177.1 BAH14127.1
    mRNA AK304784.1 BAH14257.1
    mRNA AK310432.1 None
    mRNA AY040827.1 AAK81884.1
    mRNA AY040828.1 AAK81885.1
    mRNA AY040829.1 AAK81886.1
    mRNA BC117251.1 AAI17252.1
    mRNA BC117253.1 AAI17254.1
    mRNA DA439168.1 None
    mRNA DA446656.1 None
    mRNA DC345760.1 None
    mRNA Y11416.1 CAA72219.1
      CAA72220.1
      CAA72221.1
    other-genetic HQ258345.1 ADR83099.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15350.1 GenPept UniProtKB/Swiss-Prot:O15350

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

      Table of contents

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      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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