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TP73 tumor protein p73 [ Homo sapiens (human) ]

Gene ID: 7161, updated on 23-Nov-2014
Official Symbol
TP73provided by HGNC
Official Full Name
tumor protein p73provided by HGNC
Primary source
HGNC:HGNC:12003
See related
Ensembl:ENSG00000078900; HPRD:03587; MIM:601990; Vega:OTTHUMG00000000610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P73
Summary
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
See TP73 in Epigenomics, MapViewer
Location:
1p36.3
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (3652565..3736201)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (3569129..3652765)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tumor protein p63 regulated 1-like Neighboring gene WD repeat containing, antisense to TP73 Neighboring gene TP73 antisense RNA 1 Neighboring gene coiled-coil domain containing 27 Neighboring gene small integral membrane protein 1 (Vel blood group)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-07-06)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-07-06)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat activates the p53 transcription factor pathway leading to the induction of endogenous p53 and p73 in neuronal cells PubMed
tat In the absence of either p53 or p73, Tat fails to induce dendritic retraction or to activate the proapoptotic proteins, such as Bax PubMed
tat Association of tumor protein p73 with HIV-1 Tat prevents the acetylation of Tat on lysine 28 by PCAF, and requires the cysteine-rich domain (amino acids 30 to 40) of Tat, which binds to the N-terminal region (amino acids 1 to 120) of p73 PubMed

Go to the HIV-1, Human Interaction Database

  • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligand...
  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • DNA damage response (only ATM dependent), organism-specific biosystem (from WikiPathways)
    DNA damage response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
  • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
    Direct p53 effectors, organism-specific biosystem
    Direct p53 effectors
  • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    E2F transcription factor network, organism-specific biosystem
    E2F transcription factor network
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
  • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
  • TP53 network, organism-specific biosystem (from WikiPathways)
    TP53 network, organism-specific biosystemP53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high le...
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to UV IBA
Inferred from Biological aspect of Ancestor
more info
 
cerebrospinal fluid secretion IEA
Inferred from Electronic Annotation
more info
 
digestive tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
hippocampus development IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage TAS
Traceable Author Statement
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
kidney development IEA
Inferred from Electronic Annotation
more info
 
mismatch repair TAS
Traceable Author Statement
more info
PubMed 
mitotic G1 DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
neuron development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell size IEA
Inferred from Electronic Annotation
more info
 
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
Inferred from Electronic Annotation
more info
 
positive regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
response to X-ray IBA
Inferred from Biological aspect of Ancestor
more info
 
response to gamma radiation IBA
Inferred from Biological aspect of Ancestor
more info
 
response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
tumor protein p73
Names
tumor protein p73
p53-related protein
p53-like transcription factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017035.2 

    Range
    5001..88637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001126240.2NP_001119712.1  tumor protein p73 isoform b

    See proteins identical to NP_001119712.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b, also known as deltaN p73 alpha) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AB055065, AI094238, AL136528
    Consensus CDS
    CCDS44049.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000367537, OTTHUMP00000003478, ENST00000378288, OTTHUMT00000009531
    Conserved Domains (4) summary
    cd08367
    Location:78257
    P53; P53 DNA-binding domain
    cd09571
    Location:438502
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:442501
    SAM; Sterile alpha motif
    pfam07710
    Location:302337
    P53_tetramer; P53 tetramerization motif
  2. NM_001126241.2NP_001119713.1  tumor protein p73 isoform c

    See proteins identical to NP_001119713.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (c, also known as deltaN p73 beta) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB055066, AI094238, AL136528
    Consensus CDS
    CCDS44050.1
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (2) summary
    cd08367
    Location:78257
    P53; P53 DNA-binding domain
    pfam07710
    Location:302337
    P53_tetramer; P53 tetramerization motif
  3. NM_001126242.2NP_001119714.1  tumor protein p73 isoform d

    See proteins identical to NP_001119714.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (d, also known as deltaN p73 gamma) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, AY040829
    Consensus CDS
    CCDS44051.1
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (2) summary
    cd08367
    Location:78257
    P53; P53 DNA-binding domain
    pfam07710
    Location:302337
    P53_tetramer; P53 tetramerization motif
  4. NM_001204184.1NP_001191113.1  tumor protein p73 isoform h

    See proteins identical to NP_001191113.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (h, also known as TA p73 beta) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB055066, AI094238, AL136528, Y11416
    Consensus CDS
    CCDS55566.1
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (2) summary
    cd08367
    Location:127306
    P53; P53 DNA-binding domain
    pfam07710
    Location:351386
    P53_tetramer; P53 tetramerization motif
  5. NM_001204185.1NP_001191114.1  tumor protein p73 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (i, also known as TA p73 gamma) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, AY040829, Y11416
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (2) summary
    cd08367
    Location:127306
    P53; P53 DNA-binding domain
    pfam07710
    Location:351386
    P53_tetramer; P53 tetramerization motif
  6. NM_001204186.1NP_001191115.1  tumor protein p73 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks three alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (j, also known as TA p73 delta) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, Y11416
    Consensus CDS
    CCDS59965.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000475143, OTTHUMP00000272880, ENST00000604074, OTTHUMT00000469084
    Conserved Domains (2) summary
    cd08367
    Location:127306
    P53; P53 DNA-binding domain
    pfam07710
    Location:351386
    P53_tetramer; P53 tetramerization motif
  7. NM_001204187.1NP_001191116.1  tumor protein p73 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks two alternate coding exons compared to variant 1, one that causes a frameshift and the other that corrects the frameshift. The resulting isoform (k, also known as TA p73 epsilon) has a shorter and distinct internal segment compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, Y11416
    Consensus CDS
    CCDS55567.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000350366, ENST00000357733
    Conserved Domains (3) summary
    cd08367
    Location:127306
    P53; P53 DNA-binding domain
    pfam07710
    Location:351386
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:445470
    SAM_superfamily; SAM (Sterile alpha motif )
  8. NM_001204188.1NP_001191117.1  tumor protein p73 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks two alternate coding exons compared to variant 1. The resulting isoform (l, also known as TA p73 zeta) lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, Y11416
    Consensus CDS
    CCDS55568.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000340740, ENST00000346387
    Conserved Domains (4) summary
    cd08367
    Location:127306
    P53; P53 DNA-binding domain
    smart00454
    Location:400454
    SAM; Sterile alpha motif
    pfam07710
    Location:351386
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:400455
    SAM_superfamily; SAM (Sterile alpha motif )
  9. NM_001204189.1NP_001191118.1  tumor protein p73 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks three alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (3, also known as deltaN p73 delta) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB055065, AI094238, AL136528
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (2) summary
    cd08367
    Location:78257
    P53; P53 DNA-binding domain
    pfam07710
    Location:302337
    P53_tetramer; P53 tetramerization motif
  10. NM_001204190.1NP_001191119.1  tumor protein p73 isoform f

    See proteins identical to NP_001191119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks two alternate coding exons compared to variant 1, one that causes a frameshift and the other that corrects the frameshift. The resulting isoform (f, also known as deltaN p73 epsilon) has a shorter and distinct N-terminus and a shorter and distinct internal segment compared to isoform a.
    Source sequence(s)
    AB055065, AI094238, AL136528
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (3) summary
    cd08367
    Location:78257
    P53; P53 DNA-binding domain
    pfam07710
    Location:302337
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:396421
    SAM_superfamily; SAM (Sterile alpha motif )
  11. NM_001204191.1NP_001191120.1  tumor protein p73 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks two alternate coding exons compared to variant 1. The resulting isoform (g, also known as deltaN p73 zeta) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AB055065, AI094238, AL136528
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (4) summary
    cd08367
    Location:78257
    P53; P53 DNA-binding domain
    smart00454
    Location:351405
    SAM; Sterile alpha motif
    pfam07710
    Location:302337
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:351406
    SAM_superfamily; SAM (Sterile alpha motif )
  12. NM_001204192.1NP_001191121.1  tumor protein p73 isoform m

    See proteins identical to NP_001191121.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (m) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AI094238, AK302118, AK310432, AL136528
    Consensus CDS
    CCDS55569.1
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (4) summary
    cd08367
    Location:56235
    P53; P53 DNA-binding domain
    cd09571
    Location:416480
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:420479
    SAM; Sterile alpha motif
    pfam07710
    Location:280315
    P53_tetramer; P53 tetramerization motif
  13. NM_005427.3NP_005418.1  tumor protein p73 isoform a

    See proteins identical to NP_005418.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), encodes isoform a, also known as TA p73 alpha.
    Source sequence(s)
    AI094238, AL136528, Y11416
    Consensus CDS
    CCDS49.1
    UniProtKB/TrEMBL
    A0A024R4C3
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000367545, OTTHUMP00000000662, ENST00000378295, OTTHUMT00000001468
    Conserved Domains (4) summary
    cd08367
    Location:127306
    P53; P53 DNA-binding domain
    cd09571
    Location:487551
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:491550
    SAM; Sterile alpha motif
    pfam07710
    Location:351386
    P53_tetramer; P53 tetramerization motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    2864839..2947956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    3652565..3736201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    3555405..3639797
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)