TNS1 tensin 1 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: TNS1provided by HGNC
Official Full Name: tensin 1provided by HGNC
Primary source: HGNC:11973
Locus tag: MSTP091
See related: Ensembl:ENSG00000079308; HPRD:02512; MIM:600076; Vega:OTTHUMG00000133056
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TNS; MXRA6; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; MGC88584; DKFZp586K0617
Summary: The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 2q35-q36

Sequence :: Chromosome: 2; NC_000002.11 (218664512..218808796, complement)

See TNS1 in Epigenomics, MapViewer

Chromosome 2 - NC_000002.11 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TNS1 polymorphism associated with COPD risk and lung function decline
Title: Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function.
data demonstrate that tensin1 is extensively phosphorylated on Ser/Thr residues in cells and phosphorylation by p38 MAPK regulates the specificity of the tensin1 Src homology 2 domain for binding to different proteins
Title: Comprehensive analysis of phosphorylation sites in Tensin1 reveals regulation by p38MAPK.
The expression of tensin is increased in mesangial cells with stimulating of high concentrations of glucose.
Title: [Tensin expression in mesangial cells of human kidney].
Data show expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in lung tissue and indicate potential targets for interventions to alleviate respiratory disease.
Title: Genome-wide association study identifies five loci associated with lung function.
Results suggest that PP1alpha bound to tensin1 has effects in reducing migration and invasion that are not mediated through DLC-1, and show the importance of PP1alpha binding to tensin1 for the regulation of cell polarization, migration, and invasion.
Title: Tensin1 requires protein phosphatase-1alpha in addition to RhoGAP DLC-1 to control cell polarization, migration, and invasion.
Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association study identifies five loci associated with lung function.
Tensins may represent a novel group of metastasis suppressors in the kidney, the loss of which leads to greater tumor cell motility and consequent metastasis.
Title: Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer.
Aged fibroblasts, generated with the Hayflick replicative senescence model, exhibit as siRNA silences fibroblasts, a reduced tensin1 expression and an impaired gel contraction capacity.
Title: Reduced expression of the adhesion protein tensin1 in cultured human dermal fibroblasts affects collagen gel contraction.
Observational study of gene-disease association. (HuGE Navigator)
Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
Results suggest that the protein-tyrosine phosphatase domain of tensin exhibits isoform-specific association with PP1alpha in a restricted spatial region of adhesions that are formed during cell migration.
Title: Association of the tensin N-terminal protein-tyrosine phosphatase domain with the alpha isoform of protein phosphatase-1 in focal adhesions.

Submit: New GeneRIF Correction See all (11)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study identifies five loci associated with lung function.

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
Q9HBL0	P17655	CAPN2	HPRD	PubMed
Q9HBL0	Q05397	PTK2	HPRD	PubMed
Q9HBL0	Q9HBL0	TNS1	HPRD	PubMed
BioGRID:112999	BioGRID:114934	BCAR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112999	BioGRID:112927	KLF10	BioGRID	PubMed	Two-hybrid
BioGRID:112999	BioGRID:110927	NPHP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112999	BioGRID:120779	OSGEP	BioGRID	PubMed	Two-hybrid
BioGRID:112999	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112999	BioGRID:113366	YWHAZ	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
actin binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell-substrate junction assembly	IEA Inferred from Electronic Annotation more info
fibroblast migration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell-substrate junction	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
cytoskeleton	IEA Inferred from Electronic Annotation more info
focal adhesion	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: tensin-1

Names: tensin-1; matrix-remodelling associated 6; Matrix-remodelling-associated protein 6

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022648.4 → NP_072174.3 tensin-1

Status: REVIEWED

Source sequence(s)

AB209238, AC009469, AF225896, AL706926, BC051304, BC126910

Consensus CDS

CCDS2407.1

UniProtKB/TrEMBL

A1L0S7

UniProtKB/TrEMBL

Q59G71

UniProtKB/TrEMBL

Q86VB0

UniProtKB/Swiss-Prot

Q9HBL0

Related

ENSP00000171887, OTTHUMP00000164058, ENST00000171887, OTTHUMT00000256672

Conserved Domains (4) summary

cd09927
Location:1459 – 1574
Blast Score: 558

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

pfam10409
Location:179 – 305
Blast Score: 442

PTEN_C2; C2 domain of PTEN tumour-suppressor protein

cl00053
Location:77 – 192
Blast Score: 144

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cl00273
Location:1592 – 1729
Blast Score: 577

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000002.11 Reference GRCh37.p5 Primary Assembly

Range

218664512..218808796, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000134.1 Alternate HuRef

Range

210519516..210524347, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC009469.4	AAX88952.1
genomic	CH471063.1	EAW70582.1
		EAW70583.1
		EAW70584.1
		EAW70585.1
		EAW70586.1
		EAW70587.1
mRNA	AB209238.1	BAD92475.1
mRNA	AF116610.1	AAF71035.1
mRNA	AF172820.1	AAQ13614.1
mRNA	AF173897.1	AAQ13644.1
mRNA	AF176917.1	AAQ13661.1
mRNA	AK001785.2	BAA91910.2
mRNA	AK057328.1	None
mRNA	AK300345.1	BAH13264.1
mRNA	AK309785.1	None
mRNA	AK310169.1	None
mRNA	AL117537.1	CAB55983.1
mRNA	AL706926.1	None
mRNA	BC014042.2	AAH14042.1
mRNA	BC033065.1	None
mRNA	BC051304.1	AAH51304.1
mRNA	BC063142.1	None
mRNA	BC071905.1	AAH71905.1
mRNA	BC107758.1	None
mRNA	BC116187.1	AAI16188.1
mRNA	BC116188.1	AAI16189.1
mRNA	BC126910.1	AAI26911.2
mRNA	BC140942.1	AAI40943.1
mRNA	BE142921.1	None

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q0VG54	GenPept	UniProtKB/TrEMBL:Q0VG54
Q0VG55	GenPept	UniProtKB/TrEMBL:Q0VG55
Q59G71	GenPept	UniProtKB/TrEMBL:Q59G71
Q6IPI5	GenPept	UniProtKB/TrEMBL:Q6IPI5
Q6PJM3	GenPept	UniProtKB/TrEMBL:Q6PJM3
Q86VB0	GenPept	UniProtKB/TrEMBL:Q86VB0
Q9HBL0.2	GenPept	UniProtKB/Swiss-Prot:Q9HBL0
Q9NV48	GenPept	UniProtKB/TrEMBL:Q9NV48
Q9P1L6	GenPept	UniProtKB/TrEMBL:Q9P1L6
Q9UFN8	GenPept	UniProtKB/TrEMBL:Q9UFN8