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Arhgap19 Rho GTPase activating protein 19 [ Mus musculus (house mouse) ]

Gene ID: 71085, updated on 21-Apr-2024

Summary

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Official Symbol
Arhgap19provided by MGI
Official Full Name
Rho GTPase activating protein 19provided by MGI
Primary source
MGI:MGI:1918335
See related
Ensembl:ENSMUSG00000025154 AllianceGenome:MGI:1918335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mFLJ00368; 4933411B03Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including gut; male reproductive gland or organ; and trigeminal nerve. Orthologous to human ARHGAP19 (Rho GTPase activating protein 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 16.1), testis adult (RPKM 15.6) and 17 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 35.19 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (41755027..41790523, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (41766588..41802084, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene slit guidance ligand 1 Neighboring gene predicted gene, 34116 Neighboring gene VISTA enhancer mm1552 Neighboring gene predicted gene, 19424 Neighboring gene STARR-seq mESC enhancer starr_46160 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:41843349-41843458 Neighboring gene STARR-seq mESC enhancer starr_46161 Neighboring gene STARR-positive B cell enhancer ABC_E7656 Neighboring gene predicted gene, 41847 Neighboring gene STARR-positive B cell enhancer ABC_E7657 Neighboring gene STARR-seq mESC enhancer starr_46163 Neighboring gene frequently rearranged in advanced T cell lymphomas

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. What Goes Around Can Come Around: An Unexpected Deleterious Effect of Using Mouse Running Wheels for Environmental Enrichment. Leduc RY, et al. J Am Assoc Lab Anim Sci, 2017 Mar 1. PMID 28315651, Free PMC Article
  2. Regulation of ARHGAP19 in the endometrial epithelium: a possible role in the establishment of uterine receptivity. Liang J, et al. Reprod Biol Endocrinol, 2021 Jan 7. PMID 33407571, Free PMC Article
  3. Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes. Kooistra MK, et al. Physiol Genomics, 2012 Jan 18. PMID 22045912
  4. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of ARHGAP19 in the endometrial epithelium: a possible role in the establishment of uterine receptivity.
    Title: Regulation of ARHGAP19 in the endometrial epithelium: a possible role in the establishment of uterine receptivity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Gene trapped (1) 
  • Targeted (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ00368

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 19
Names
rho-type GTPase-activating protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163495.1 → NP_001156967.1  rho GTPase-activating protein 19 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1, that causes a frameshift. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC145557, BC086680
    Consensus CDS
    CCDS50435.1
    UniProtKB/TrEMBL
    E9Q4T1
    Related
    ENSMUSP00000129586.2, ENSMUST00000163265.9
    Conserved Domains (1) summary
    cd04392
    Location:113 → 320
    RhoGAP_ARHGAP19; RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

  2. NM_027667.3 → NP_081943.2  rho GTPase-activating protein 19 isoform 1

    See identical proteins and their annotated locations for NP_081943.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC145557, BC086680
    Consensus CDS
    CCDS37989.1
    UniProtKB/Swiss-Prot
    B9EI55, Q0VGS7, Q5DU53, Q8BRH3, Q9D468
    Related
    ENSMUSP00000026150.9, ENSMUST00000026150.15
    Conserved Domains (1) summary
    cd04392
    Location:113 → 320
    RhoGAP_ARHGAP19; RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    41755027..41790523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161690.1 → XP_036017583.1  rho GTPase-activating protein 19 isoform X6

    Conserved Domains (1) summary
    cd04392
    Location:107 → 293
    RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

  2. XM_036161689.1 → XP_036017582.1  rho GTPase-activating protein 19 isoform X5

  3. XM_011247341.2 → XP_011245643.1  rho GTPase-activating protein 19 isoform X1

    Conserved Domains (1) summary
    cd04392
    Location:104 → 311
    RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

  4. XM_011247343.2 → XP_011245645.1  rho GTPase-activating protein 19 isoform X3

    Conserved Domains (1) summary
    cd04392
    Location:104 → 311
    RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

  5. XM_011247342.2 → XP_011245644.1  rho GTPase-activating protein 19 isoform X2

    Conserved Domains (1) summary
    cd04392
    Location:104 → 311
    RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

  6. XM_011247344.4 → XP_011245646.3  rho GTPase-activating protein 19 isoform X4

    Conserved Domains (1) summary
    cd04392
    Location:98 → 284
    RhoGAP_ARHGAP19; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BRH3.2 GenPept UniProtKB/Swiss-Prot:Q8BRH3

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