Display Settings:

Format

Send to:

Choose Destination

TK1 thymidine kinase 1, soluble [ Homo sapiens (human) ]

Gene ID: 7083, updated on 26-Aug-2014
Official Symbol
TK1provided by HGNC
Official Full Name
thymidine kinase 1, solubleprovided by HGNC
Primary source
HGNC:11830
See related
Ensembl:ENSG00000167900; HPRD:01771; MIM:188300; Vega:OTTHUMG00000150674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TK2
Location:
17q23.2-q25.3
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 17 NC_000017.11 (78174079..78187204, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76170160..76183285, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromosome 17 open reading frame 99 Neighboring gene uncharacterized LOC102723826 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 2 Neighboring gene synaptogyrin 2 Neighboring gene arylformamidase Neighboring gene baculoviral IAP repeat containing 5 Neighboring gene transmembrane protein 235

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
 
nucleoside kinase activity EXP
Inferred from Experiment
more info
 
thymidine kinase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
deoxyribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
deoxyribonucleoside monophosphate biosynthetic process TAS
Traceable Author Statement
more info
PubMed 
digestive tract development IEA
Inferred from Electronic Annotation
more info
 
fetal process involved in parturition IEA
Inferred from Electronic Annotation
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
nucleobase-containing small molecule metabolic process TAS
Traceable Author Statement
more info
 
nucleotide biosynthetic process EXP
Inferred from Experiment
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein homotetramerization IPI
Inferred from Physical Interaction
more info
PubMed 
pyrimidine nucleobase metabolic process TAS
Traceable Author Statement
more info
 
pyrimidine nucleoside salvage TAS
Traceable Author Statement
more info
 
response to copper ion IEA
Inferred from Electronic Annotation
more info
 
response to cortisol IEA
Inferred from Electronic Annotation
more info
 
response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
skeletal muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
thymidine metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
thymidine kinase, cytosolic
Names
thymidine kinase, cytosolic
thymidine kinase-1
thymidine kinase 1 soluble isoform
NP_003249.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003258.4NP_003249.3  thymidine kinase, cytosolic

    See proteins identical to NP_003249.3

    Status: VALIDATED

    Source sequence(s)
    AA633286, BC006484, BI754079
    Consensus CDS
    CCDS11754.1
    UniProtKB/Swiss-Prot
    P04183
    Related
    ENSP00000301634, OTTHUMP00000198229, ENST00000301634, OTTHUMT00000319577
    Conserved Domains (1) summary
    cl18944
    Location:18192
    Blast Score: 782
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 

    Range
    78174079..78187204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257631.1XP_005257688.1  

    Conserved Domains (1) summary
    cl18944
    Location:34124
    Blast Score: 444
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...

Alternate HuRef

Genomic

  1. AC_000149.1 

    Range
    71594292..71607377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 

    Range
    76234697..76247823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)