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C1QBP complement component 1, q subcomponent binding protein [ Homo sapiens (human) ]

Gene ID: 708, updated on 14-May-2013

Summary

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Official Symbol: C1QBPprovided by HGNC
Official Full Name: complement component 1, q subcomponent binding proteinprovided by HGNC
Primary source: HGNC:1243
See related: Ensembl:ENSG00000108561; HPRD:03168; MIM:601269; Vega:OTTHUMG00000177875
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: p32; HABP1; gC1qR; GC1QBP; SF2p32; gC1Q-R
Summary: The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 17p13.3

Sequence :: Chromosome: 17; NC_000017.10 (5336099..5342471, complement)

See C1QBP in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

in ovarian serous carcinoma, HABP1 overexpression was correlated to histological-differentiation, residual tumor-size, serum CA-125 and stage; increased expression associated with cisplatin resistance; HAPBP1 overexpression in primary ovarian carcinomas is related to decrease in overall survival and progression free survival
Title: Significance of hyaluronan binding protein (HABP1/P32/gC1qR) expression in advanced serous ovarian cancer patients.
polymorphisms in HABP1 are potentially involved in glaucomatous neurodegeneration.
Title: Genetic association and gene-gene interaction of HAS2, HABP1 and HYAL3 implicate hyaluronan metabolic genes in glaucomatous neurodegeneration.
C1q/gC1qR may regulate dendritic cells differentiation and function through the DC-SIGN-mediated induction of cell-signaling pathways.
Title: DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells.
C1qbp is upregulated in human lung and colon cancer cell lines and tumors.
Title: The mitochondrial protein C1qbp promotes cell proliferation, migration and resistance to cell death.
Overexpression of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) in HepG2 cells leads to increased hyaluronan synthesis and cell proliferation by up-regulation of cyclin D1 in AKT-dependent pathway.
Title: Overexpression of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) in HepG2 cells leads to increased hyaluronan synthesis and cell proliferation by up-regulation of cyclin D1 in AKT-dependent pathway.
p32 is a new rRNA maturation factor involved in the remodeling from pre-90S particles to pre-40S and pre-60S particles that requires the exchange of FBL for Nop52.
Title: Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles.
we have identified a mitochondrial protein p32 as a novel interactor of parkin in the brain
Title: p32 regulates mitochondrial morphology and dynamics through parkin.
gC1qR could play an important role in HPV-16-induced cervical cancer immune evasion depending on its level of expression and subcellular localisation.
Title: The role of gC1qR in regulating survival of human papillomavirus 16 oncogene-transfected cervical cancer cells.
HABP1 interacts with cell surface receptor integrin alphaVbeta3 that induces cell migration and tumor growth mediated by transcription factor NF-kappa B, membrane type-1 matrix metalloproteinase and matrix metalloprotease-2.
Title: Hyaluronan-binding protein 1 (HABP1/p32/gC1qR) induces melanoma cell migration and tumor growth by NF-kappa B dependent MMP-2 activation through integrin α(v)β(3) interaction.
there is a a role for platelet-mediated clumping, rosetting and adhesion to gC1qR in the pathogenesis of severe malaria
Title: Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.

Submit: New GeneRIF Correction See all (47)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of C1q globular domain-binding protein in umbilical cord blood mononuclear cells	PubMed
Envelope transmembrane glycoprotein gp41	env	HIV-1 gp41 S3 motif engages gC1qR on CD4+ T cells to induce the expression of an NK ligand (NKp44L) through the PIP3/H2O2 pathway	PubMed
Rev, p19	rev	Rev binding to p32 is associated with the function of Rev in inhibiting the splicing of HIV-1 mRNA by splicing factors ASF/SF2	PubMed
	rev	Rev bridges the association of p32 with RRE RNA	PubMed
	rev	Human p32 protein relieves a post-transcriptional block to HIV-1 replication in murine cells by restoring HIV-1 Rev function	PubMed
	rev	p32 binds to the basic domain of HIV-1 Rev (amino acids 35-50)	PubMed
Tat, p14	tat	Splicing factor SF2-associated protein p32 preferentially binds acetylated HIV-1 Tat and co-localizes with Tat in HIV-1 infected cells	PubMed
	tat	Using a yeast two-hybrid system, the splicing factor SF2-associated protein p32 has been shown to bind to the basic domain of HIV-1 Tat (amino acids 47-59), suggesting a role for p32 in mediating the biological activity of Tat during HIV-1 replication	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001203.1		CBFB	BIND	PubMed	p32 interacts with CBF-B.
Q07021	P02745	C1QA	HPRD	PubMed
Q07021	Q07021	C1QBP	HPRD	PubMed
Q07021	P38432	COIL	HPRD	PubMed
Q07021	Exosome component 6	EXOSC6	HPRD	PubMed
Q07021	Q13480	GAB1	HPRD	PubMed
Q07021	P18505	GABRB1	HPRD	PubMed
Q07021	Q5JVS0	HABP4	HPRD	PubMed
Q07021	O00198	HRK	HPRD	PubMed
Q07021	P28482	MAPK1	HPRD	PubMed
Q07021	P27361	MAPK3	HPRD	PubMed
Q07021	P50281	MMP14	HPRD	PubMed
Q07021	P25208	NFYB	HPRD	PubMed
Q07021	P17252	PRKCA	HPRD	PubMed
Q07021	Q05655	PRKCD	HPRD	PubMed
Q07021	Q05513	PRKCZ	HPRD	PubMed
Q07021	Q15139	PRKD1	HPRD	PubMed
Q07021	P48634	PRRC2A	HPRD	PubMed
Q07021	Q07955	SRSF1	HPRD	PubMed
Q07021	Q13242	SRSF9	HPRD	PubMed
Q07021	O95985	TOP3B	HPRD	PubMed
Q07021	P31946	YWHAB	HPRD	PubMed
Q07021	P61981	YWHAG	HPRD	PubMed
BioGRID:107169	BioGRID:106902	ARRB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:120937	CAND1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:107434	CDH1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:107479	CEBPA	BioGRID	PubMed	Two-hybrid
BioGRID:107169	BioGRID:116056	CLPX	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:113815	COIL	BioGRID	PubMed	Two-hybrid
BioGRID:107169	BioGRID:116183	COPS5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:116176	COPS6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:114032	CUL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:114031	CUL2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:114030	CUL3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:114029	CUL4A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:114028	CUL4B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:113743	CUL5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:232850	Ccdc15	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:206490	Cdca8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:205180	Csnk1e	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:113587	DAP3	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:107169	BioGRID:119920	DCUN1D1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:108325	EMD	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:117666	ERAL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:199505	Erh	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:222968	Espl1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:108399	FBL	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:108621	FN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:123976	FYTTD1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:108824	GAB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107169	BioGRID:109127	GRK5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:116587	HABP4	BioGRID	PubMed	Two-hybrid
BioGRID:107169	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:109544	HSPA8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:109545	HSPA9	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:109561	HSPD1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:109622	ICT1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:109931	JUP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:115114	KIAA0101	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:114762	LONP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:115432	LRPPRC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:211917	Lsm14a	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:111580	MAPK1	BioGRID	PubMed	Biochemical Activity
BioGRID:107169	BioGRID:111581	MAPK3	BioGRID	PubMed	Biochemical Activity
BioGRID:107169	BioGRID:136699	MINOS1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:110466	MMP14	BioGRID	PubMed	Protein-peptide
BioGRID:107169	BioGRID:112097	MRPL12	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:118846	MRPL18	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:115142	MRPL19	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:128594	MRPL21	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:118862	MRPL22	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:116390	MRPL3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107169	BioGRID:122365	MRPL38	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:119264	MRPL4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:122389	MRPL44	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:124037	MRPL45	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:117757	MRPL46	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:120472	MRPS10	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:119304	MRPS2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:121269	MRPS22	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:107169	BioGRID:119657	MRPS23	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:122180	MRPS25	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:122356	MRPS26	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:116731	MRPS27	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:118784	MRPS28	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:116091	MRPS30	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:122442	MRPS34	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:122362	MRPS5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:119271	MRPS7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:122360	MRPS9	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:110694	MYC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:220434	Mrpl3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107169	BioGRID:211091	Mrps22	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107169	BioGRID:110758	NARS	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:115246	NCAPD2	BioGRID	PubMed	Co-fractionation
BioGRID:107169	BioGRID:110815	NEDD8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:110861	NFKBIE	BioGRID	PubMed	Two-hybrid
BioGRID:107169	BioGRID:110906	NOS2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:121386	NUP107	BioGRID	PubMed	Co-fractionation
BioGRID:107169	BioGRID:115297	NUP153	BioGRID	PubMed	Co-fractionation
BioGRID:107169	BioGRID:203509	Nhp2l1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:111105	PARK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107169	BioGRID:111136	PCK1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:115434	PDIA6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:111264	PHB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:116459	PHB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:114909	POLR1C	BioGRID	PubMed	Co-fractionation
BioGRID:107169	BioGRID:111510	PPP2R1A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:111564	PRKCA	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107169	BioGRID:111566	PRKCD	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107169	BioGRID:111576	PRKCZ	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107169	BioGRID:111573	PRKD1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:107169	BioGRID:113646	PRRC2A	BioGRID	PubMed	Two-hybrid
BioGRID:107169	BioGRID:111639	PSAP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:115492	PSME3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:120366	PTCD3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:214756	Pds5a	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:111822	RAD21	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107169	BioGRID:215383	Rrp1b	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:112346	SGSH	BioGRID	PubMed	Co-fractionation
BioGRID:107169	BioGRID:126754	SREK1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:112324	SRSF1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107169	BioGRID:114231	SRSF9	BioGRID	PubMed	Far Western
BioGRID:107169	BioGRID:236230	Soga1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:112791	TCF3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:112877	TFAM	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:107169	BioGRID:122106	TFB2M	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:115716	TOMM40	BioGRID	PubMed	Co-fractionation
BioGRID:107169	BioGRID:115435	TRAP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:120760	TRMT1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:115409	TSFM	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:113135	TUFM	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:204137	Tfam	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107169	BioGRID:204197	Trim28	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:113885	UBL4A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:113353	XRCC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:114101	YBX3	BioGRID	PubMed	Co-fractionation
BioGRID:107169	BioGRID:113361	YWHAB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:113363	YWHAE	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:113364	YWHAG	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107169	BioGRID:1205541	tat	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem (from REACTOME)
Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystemThe formation of a fibrin clot at the site of an injury to the wall of a normal blood vessel is an essential part of the process to stop blood loss after vascular injury. The reactions that lead to ...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Intrinsic Pathway, organism-specific biosystem (from REACTOME)
Intrinsic Pathway, organism-specific biosystemThe intrinsic pathway of blood clotting connects interactions among kininogen (high molecular weight kininogen, HK), prekallikrein (PK), and factor XII to the activation of clotting factor X by a ser...

General gene information

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Markers

D17S2014 (e-PCR)
- UniSTS:69376

STS-R63801 (e-PCR)
- UniSTS:45701

WI-18770 (e-PCR)
- UniSTS:19911

RH78721 (e-PCR)
- UniSTS:80126

Homology

Homologs of the C1QBP gene: The C1QBP gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and C.elegans.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
adrenergic receptor binding	ISS Inferred from Sequence or Structural Similarity more info
complement component C1q binding	IDA Inferred from Direct Assay more info	PubMed
hyaluronic acid binding	IDA Inferred from Direct Assay more info	PubMed
kininogen binding	IDA Inferred from Direct Assay more info	PubMed
mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
mitochondrial ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase C binding	IEA Inferred from Electronic Annotation more info
transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
transcription factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
RNA splicing	IEA Inferred from Electronic Annotation more info
apoptotic process	IEA Inferred from Electronic Annotation more info
blood coagulation	TAS Traceable Author Statement more info
blood coagulation, intrinsic pathway	TAS Traceable Author Statement more info
complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
immune response	TAS Traceable Author Statement more info	PubMed
innate immune response	IEA Inferred from Electronic Annotation more info
mRNA processing	IEA Inferred from Electronic Annotation more info
mature ribosome assembly	IMP Inferred from Mutant Phenotype more info
negative regulation of MDA-5 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of RIG-I signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of interferon-gamma production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
negative regulation of mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
phosphatidylinositol 3-kinase cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell adhesion	IMP Inferred from Mutant Phenotype more info
positive regulation of dendritic cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of mitochondrial translation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein kinase B signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of trophoblast cell migration	IMP Inferred from Mutant Phenotype more info
regulation of complement activation	IDA Inferred from Direct Assay more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
virus-host interaction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell surface	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
cytosol	IDA Inferred from Direct Assay more info	PubMed
extracellular space	IEA Inferred from Electronic Annotation more info
membrane	IDA Inferred from Direct Assay more info	PubMed
mitochondrial matrix	IEA Inferred from Electronic Annotation more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
nucleolus	IEA Inferred from Electronic Annotation more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: complement component 1 Q subcomponent-binding protein, mitochondrial

Names: complement component 1 Q subcomponent-binding protein, mitochondrial; p33; glycoprotein gC1qBP; hyaluronan-binding protein 1; ASF/SF2-associated protein p32; mitochondrial matrix protein p32; C1q globular domain-binding protein; splicing factor SF2-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001212.3 → NP_001203.1 complement component 1 Q subcomponent-binding protein, mitochondrial precursor

Status: REVIEWED

Source sequence(s)

L04636

Consensus CDS

CCDS11071.1

UniProtKB/Swiss-Prot

Q07021

Related

ENSP00000225698, OTTHUMP00000257863, ENST00000225698, OTTHUMT00000439388

Conserved Domains (1) summary

pfam02330
Location:86 – 279
Blast Score: 612

MAM33; Mitochondrial glycoprotein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p10 Primary Assembly

Range

5336099..5342471, complement

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Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

5226626..5232998, complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018928.1 Alternate CHM1_1.0

Range

5323956..5330326, complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01054814.1 (14517..20889)	None
genomic	AC004148.1 (60317..66689)	None
genomic	AF338439.1	AAK26580.1
genomic	AMYH01008051.1 (32634..39004)	None
genomic	CH471108.2	EAW90335.1
		EAW90336.1
		EAW90337.1
genomic	DQ372108.1	ABC79624.1
mRNA	AF275902.1	AAF78763.1
mRNA	AJ297362.1	CAB95947.1
mRNA	AK291516.1	BAF84205.1
mRNA	BC000435.2	AAH00435.1
mRNA	BC013731.1	AAH13731.1
mRNA	BT019898.1	AAV38701.1
mRNA	BT019899.1	AAV38702.1
mRNA	L04636.1	AAA16315.1
mRNA	X75913.1	CAA53512.1
other-genetic	DQ891331.2	ABM82257.1
other-genetic	DQ893366.2	ABM84292.1
other-genetic	DQ894514.2	ABM85440.1
other-genetic	DQ896683.2	ABM87682.1