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    C1QBP complement component 1, q subcomponent binding protein [ Homo sapiens ]

    Gene ID: 708, updated on 11-May-2012
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    Summary

    Official Symbol
    C1QBPprovided by HGNC
    Official Full Name
    complement component 1, q subcomponent binding proteinprovided by HGNC
    Primary source
    HGNC:1243
    See related
    Ensembl:ENSG00000108561; HPRD:03168; MIM:601269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p32; HABP1; gC1qR; GC1QBP; SF2p32; gC1Q-R
    Summary
    The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    17p13.3
    Sequence :
    Chromosome: 17; NC_000017.10 (5336099..5342471, complement)
    See C1QBP in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene rabaptin, RAB GTPase binding effector protein 1 Neighboring gene nucleoporin 88kDa Neighboring gene RPA interacting protein Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 33 Neighboring gene derlin 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A cohesin-RAD21 interactome. Panigrahi AK, et al. Biochem J, 2012 Mar 15. PMID 22145905.
    2. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Altun M, et al. Chem Biol, 2011 Nov 23. PMID 22118674.
    3. MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization. Alkhaja AK, et al. Mol Biol Cell, 2012 Jan. PMID 22114354.
    4. p32 regulates mitochondrial morphology and dynamics through parkin. Li Y, et al. Neuroscience, 2011 Dec 29. PMID 22008525.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (94) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. we have identified a mitochondrial protein p32 as a novel interactor of parkin in the brain
      Title: p32 regulates mitochondrial morphology and dynamics through parkin.
    2. gC1qR could play an important role in HPV-16-induced cervical cancer immune evasion depending on its level of expression and subcellular localisation.
      Title: The role of gC1qR in regulating survival of human papillomavirus 16 oncogene-transfected cervical cancer cells.
    3. HABP1 interacts with cell surface receptor integrin alphaVbeta3 that induces cell migration and tumor growth mediated by transcription factor NF-kappa B, membrane type-1 matrix metalloproteinase and matrix metalloprotease-2.
      Title: Hyaluronan-binding protein 1 (HABP1/p32/gC1qR) induces melanoma cell migration and tumor growth by NF-kappa B dependent MMP-2 activation through integrin α(v)β(3) interaction.
    4. there is a a role for platelet-mediated clumping, rosetting and adhesion to gC1qR in the pathogenesis of severe malaria
      Title: Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor.
    5. cell-surface gC1qR regulates lamellipodia formation and metastasis via receptor tyrosine kinase activation.
      Title: Cell-surface receptor for complement component C1q (gC1qR) is a key regulator for lamellipodia formation and cancer metastasis.
    6. The data presented suggest that p32 fulfills an essential function for rubella virus replication in directing trafficking of mitochondria near sites of viral replication to meet the energy demands of the virus.
      Title: Involvement of p32 and microtubules in alteration of mitochondrial functions by rubella virus.
    7. the potential of p32 for antibody-based tumor targeting strategies and the utility of the 2.15 antibody as targeting moiety for the selective delivery of imaging and therapeutic agents to tumors.
      Title: The multicompartmental p32/gClqR as a new target for antibody-based tumor targeting strategies.
    8. p32 is highly expressed in prostate tumor samples and its expression is significantly associated with the Gleason score, pathological stage and relapse
      Title: Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomy.
    9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    10. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
    Submit: New GeneRIF Correction See all (43)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Rev rev Human p32 protein relieves a post-transcriptional block to HIV-1 replication in murine cells by restoring HIV-1 Rev function PubMed
    rev Rev binding to p32 is associated with the function of Rev in inhibiting the splicing of HIV-1 mRNA by splicing factors ASF/SF2 PubMed
    rev Rev bridges the association of p32 with RRE RNA PubMed
    rev p32 binds to the basic domain of HIV-1 Rev (amino acids 35-50) PubMed
    Tat tat Splicing factor SF2-associated protein p32 preferentially binds acetylated HIV-1 Tat and co-localizes with Tat in HIV-1 infected cells PubMed
    tat Using a yeast two-hybrid system, the splicing factor SF2-associated protein p32 has been shown to bind to the basic domain of HIV-1 Tat (amino acids 47-59), suggesting a role for p32 in mediating the biological activity of Tat during HIV-1 replication PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001203.1 CBFB    BIND  PubMed p32 interacts with CBF-B. 
    Q07021 P02745 C1QA    HPRD  PubMed  
    Q07021 Q07021 C1QBP    HPRD  PubMed  
    Q07021 P38432 COIL    HPRD  PubMed  
    Q07021 Exosome component 6 EXOSC6    HPRD  PubMed  
    Q07021 Q13480 GAB1    HPRD  PubMed  
    Q07021 P18505 GABRB1    HPRD  PubMed  
    Q07021 Q5JVS0 HABP4    HPRD  PubMed  
    Q07021 O00198 HRK    HPRD  PubMed  
    Q07021 P28482 MAPK1    HPRD  PubMed  
    Q07021 P27361 MAPK3    HPRD  PubMed  
    Q07021 P50281 MMP14    HPRD  PubMed  
    Q07021 P25208 NFYB    HPRD  PubMed  
    Q07021 P17252 PRKCA    HPRD  PubMed  
    Q07021 Q05655 PRKCD    HPRD  PubMed  
    Q07021 Q05513 PRKCZ    HPRD  PubMed  
    Q07021 Q15139 PRKD1    HPRD  PubMed  
    Q07021 P48634 PRRC2A    HPRD  PubMed  
    Q07021 Q07955 SRSF1    HPRD  PubMed  
    Q07021 Q13242 SRSF9    HPRD  PubMed  
    Q07021 O95985 TOP3B    HPRD  PubMed  
    Q07021 P31946 YWHAB    HPRD  PubMed  
    Q07021 P61981 YWHAG    HPRD  PubMed  
    BioGRID:107169 BioGRID:236230 9830001H06Rik    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:232850 Ccdc15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:206490 Cdca8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:205180 Csnk1e    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:108325 EMD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:199505 Erh    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:222968 Espl1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:108399 FBL    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:108824 GAB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107169 BioGRID:116587 HABP4    BioGRID  PubMed Two-hybrid 
    BioGRID:107169 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:109622 ICT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:211917 Lsm14a    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:111580 MAPK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107169 BioGRID:111581 MAPK3    BioGRID  PubMed Biochemical Activity 
    BioGRID:107169 BioGRID:136699 MINOS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:110466 MMP14    BioGRID  PubMed Protein-peptide 
    BioGRID:107169 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:203509 Nhp2l1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:111105 PARK2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107169 BioGRID:111136 PCK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:111564 PRKCA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107169 BioGRID:111566 PRKCD    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107169 BioGRID:111576 PRKCZ    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107169 BioGRID:111573 PRKD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107169 BioGRID:113646 PRRC2A    BioGRID  PubMed Two-hybrid 
    BioGRID:107169 BioGRID:214756 Pds5a    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:111822 RAD21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107169 BioGRID:215383 Rrp1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:126754 SREK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:112324 SRSF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107169 BioGRID:114231 SRSF9    BioGRID  PubMed Far Western 
    BioGRID:107169 BioGRID:204197 Trim28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:113361 YWHAB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107169 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem (from REACTOME)
      Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystemThe formation of a fibrin clot at the site of an injury to the wall of a normal blood vessel is an essential part of the process to stop blood loss after vascular injury. The reactions that lead to ...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Intrinsic Pathway, organism-specific biosystem (from REACTOME)
      Intrinsic Pathway, organism-specific biosystemThe intrinsic pathway of blood clotting connects interactions among kininogen (high molecular weight kininogen, HK), prekallikrein (PK), and factor XII to the activation of clotting factor X by a ser...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    complement component C1q binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase C binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    blood coagulation, intrinsic pathway TAS
    Traceable Author Statement
    more info
    		  
    immune response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    complement component 1 Q subcomponent-binding protein, mitochondrial
    Names
    complement component 1 Q subcomponent-binding protein, mitochondrial
    p33
    glycoprotein gC1qBP
    hyaluronan-binding protein 1
    mitochondrial matrix protein p32
    C1q globular domain-binding protein
    splicing factor SF2-associated protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001212.3 → NP_001203.1  complement component 1 Q subcomponent-binding protein, mitochondrial precursor

      Status: REVIEWED

      Source sequence(s)
      L04636
      Consensus CDS
      CCDS11071.1
      UniProtKB/Swiss-Prot
      Q07021
      Related
      ENSP00000225698, ENST00000225698
      Conserved Domains (1) summary
      pfam02330
      Location:86 – 279
      Blast Score: 612
      MAM33; Mitochondrial glycoprotein

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      5336099..5342471, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      5226626..5232998, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC004148.1 (60316..66688) None
    genomic AF338439.1 AAK26580.1
    genomic CH471108.2 EAW90335.1
      EAW90336.1
      EAW90337.1
    genomic DQ372108.1 ABC79624.1
    mRNA AF275902.1 AAF78763.1
    mRNA AJ297362.1 CAB95947.1
    mRNA AK291516.1 BAF84205.1
    mRNA BC000435.2 AAH00435.1
    mRNA BC013731.1 AAH13731.1
    mRNA BT019898.1 AAV38701.1
    mRNA BT019899.1 AAV38702.1
    mRNA L04636.1 AAA16315.1
    mRNA X75913.1 CAA53512.1
    other-genetic DQ891331.2 ABM82257.1
    other-genetic DQ893366.2 ABM84292.1
    other-genetic DQ894514.2 ABM85440.1
    other-genetic DQ896683.2 ABM87682.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07021.1 GenPept UniProtKB/Swiss-Prot:Q07021
    Q9NQ45 GenPept UniProtKB/TrEMBL:Q9NQ45
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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