TIMP4 TIMP metallopeptidase inhibitor 4 [Homo sapiens] - Gene

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Summary

Official Symbol: TIMP4provided by HGNC
Official Full Name: TIMP metallopeptidase inhibitor 4provided by HGNC
Primary source: HGNC:11823
See related: Ensembl:ENSG00000157150; HPRD:03557; MIM:601915; Vega:OTTHUMG00000129763
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 3p25

Sequence :: Chromosome: 3; NC_000003.11 (12194568..12200851, complement)

See TIMP4 in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Heterogeneous methylation in the promoter region of TIMP4 was associated with cancer progression in non-small cell lung cancer.
Title: Heterogeneity and degree of TIMP4, GATA4, SOX18, and EGFL7 gene promoter methylation in non-small cell lung cancer and surrounding tissues.
A trend toward increased serum levels of MMP-9/TIMP-4 was found in patients with successful arteriovenous fistulas.
Title: Serum metalloproteinases MMP-2, MMP-9, and metalloproteinase tissue inhibitors in patients are associated with arteriovenous fistula maturation.
Plasma TIMP-4 has a role in the prediction of LV remodeling and the pathophysiology of the heart postinfarction
Title: Plasma TIMP-4 predicts left ventricular remodeling after acute myocardial infarction.
MMP-10 and -7 abundance increased, accompanied by decreased TIMP-4 in dilated cardiomyopathy failing hearts compared with non-failing hearts.
Title: Type-specific dysregulation of matrix metalloproteinases and their tissue inhibitors in end-stage heart failure patients: relationship between MMP-10 and LV remodelling.
TIMP4 expression is a downstream target of GCM1
Title: Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi.
Expressions of MMP1, MMP9, TIMP4, and EMMPRIN were significantly unbalanced in the myocardium of congestive heart failure patients with rheumatic heart diseases.
Title: [Expression and significance of matrix metalloproteinase-1,9, tissue inhibitor of metalloproteinase-4 and extracellular matrix metalloproteinase inducer in the myocardium of congestive heart failure in patients with rheumatic heart diseases].
this work provides the first evidence of a TIMP-4/CD63 association in astrocytoma tumor cells
Title: TIMP-4 and CD63: new prognostic biomarkers in human astrocytomas.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
TIMP-4 as a simple prognostic marker that may help identify patients with early-stage breast cancer who could benefit from more aggressive treatment at diagnosis
Title: Tissue inhibitor of metalloproteinase-4 is elevated in early-stage breast cancers with accelerated progression and poor clinical course.
TIMP4 is related to the development of KD with CALs in Korean children.
Title: Promoter polymorphism (rs3755724, -55C/T) of tissue inhibitor of metalloproteinase 4 (TIMP4) as a risk factor for Kawasaki disease with coronary artery lesions in a Korean population.

Submit: New GeneRIF Correction See all (30)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q99727	P50281	MMP14	HPRD	PubMed
Q99727	P08253	MMP2	HPRD	PubMed
BioGRID:112935	BioGRID:110457	MMP2	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
enzyme inhibitor activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
metalloendopeptidase inhibitor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
biological_process	ND No biological Data available more info
central nervous system development	IEA Inferred from Electronic Annotation more info
ovulation cycle	IEA Inferred from Electronic Annotation more info
response to cytokine stimulus	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
response to peptide hormone stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
extracellular region	NAS Non-traceable Author Statement more info
extracellular space	IEA Inferred from Electronic Annotation more info
sarcomere	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: metalloproteinase inhibitor 4

Names: metalloproteinase inhibitor 4; TIMP-4; tissue inhibitor of metalloproteinase 4; tissue inhibitor of metalloproteinases 4

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003256.3 → NP_003247.1 metalloproteinase inhibitor 4 precursor

Status: REVIEWED

Source sequence(s)

BC010553

Consensus CDS

CCDS2608.1

UniProtKB/Swiss-Prot

Q99727

Related

ENSP00000287814, OTTHUMP00000160184, ENST00000287814, OTTHUMT00000251978

Conserved Domains (1) summary

cd03585
Location:30 – 213
Blast Score: 750

NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p5 Primary Assembly

Range

12194568..12200851, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

12128374..12134601, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC026166.5 (144082..150161)	None
genomic	AF057532.1	AAC34422.1
genomic	CH471055.1	EAW64122.1
mRNA	AK313018.1	BAG35853.1
mRNA	BC010553.1	AAH10553.1
mRNA	BT019627.1	AAV38433.1
mRNA	U76456.1	AAB40391.1
other-genetic	DQ891795.2	ABM82721.1
other-genetic	DQ894978.2	ABM85904.1