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TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 [ Homo sapiens (human) ]

Gene ID: 7073, updated on 11-Jul-2015
Official Symbol
TIAL1provided by HGNC
Official Full Name
TIA1 cytotoxic granule-associated RNA binding protein-like 1provided by HGNC
Primary source
HGNC:HGNC:11804
See related
HPRD:04563; MIM:603413
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCBP; TIAR
Summary
The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
Orthologs
See TIAL1 in Epigenomics, MapViewer
Location:
10q
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (119573465..119597029, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (121332977..121356541, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 5 Neighboring gene uncharacterized LOC105378510 Neighboring gene regulator of G-protein signaling 10 Neighboring gene uncharacterized LOC105378512 Neighboring gene RAD1 pseudogene 1 Neighboring gene ribosomal protein S8 pseudogene 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag co-localizes and interacts with G3BP1 and TIAR to modulate stress granule assembly during HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC33401

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AU-rich element binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
defense response TAS
Traceable Author Statement
more info
PubMed 
germ cell development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
stem cell division IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
lysosome TAS
Traceable Author Statement
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
nucleolysin TIAR
Names
T-cluster binding protein
TIA-1-related nucleolysin
aging-associated gene 7 protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029240.1 RefSeqGene

    Range
    5001..28565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001033925.1NP_001029097.1  nucleolysin TIAR isoform 2

    See identical proteins and their annotated locations for NP_001029097.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a longer protein (isoform 2).
    Source sequence(s)
    AA972022, AC012468, AK125264, BC030025, M96954
    Consensus CDS
    CCDS31295.1
    UniProtKB/Swiss-Prot
    Q01085
    UniProtKB/TrEMBL
    Q49AS9
    Conserved Domains (4) summary
    COG0724
    Location:8284
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12616
    Location:10107
    RRM1_TIAR; RNA recognition motif 1 in nucleolysin TIAR and similar proteins
    cd12617
    Location:113192
    RRM2_TIAR; RNA recognition motif 2 in nucleolysin TIAR and similar proteins
    cd12620
    Location:222294
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
  2. NM_003252.3NP_003243.1  nucleolysin TIAR isoform 1

    See identical proteins and their annotated locations for NP_003243.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AA972022, AC012468, AK125264, AL833106, BC030025
    Consensus CDS
    CCDS7613.1
    UniProtKB/Swiss-Prot
    Q01085
    UniProtKB/TrEMBL
    Q49AS9
    Conserved Domains (4) summary
    cd12616
    Location:1090
    RRM1_TIAR; RNA recognition motif 1 in nucleolysin TIAR and similar proteins
    cd12617
    Location:96175
    RRM2_TIAR; RNA recognition motif 2 in nucleolysin TIAR and similar proteins
    cd12620
    Location:205277
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
    TIGR01661
    Location:7271
    ELAV_HUD_SF; ELAV/HuD family splicing factor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    119573465..119597029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270109.1XP_005270166.1  

    See identical proteins and their annotated locations for XP_005270166.1

    UniProtKB/TrEMBL
    Q49AS9
    Conserved Domains (3) summary
    smart00360
    Location:83149
    RRM; RNA recognition motif
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_005270108.1XP_005270165.1  

    See identical proteins and their annotated locations for XP_005270165.1

    Conserved Domains (4) summary
    smart00360
    Location:77147
    RRM; RNA recognition motif
    cd12617
    Location:74153
    RRM2_TIAR; RNA recognition motif 2 in nucleolysin TIAR and similar proteins
    cd12620
    Location:183255
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
    cl17169
    Location:1968
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_005270110.3XP_005270167.1  

    See identical proteins and their annotated locations for XP_005270167.1

    UniProtKB/TrEMBL
    Q49AS9
    Conserved Domains (3) summary
    smart00360
    Location:83149
    RRM; RNA recognition motif
    cd12620
    Location:82154
    RRM3_TIAR; RNA recognition motif 3 in nucleolysin TIAR and similar proteins
    cl17169
    Location:252
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_945808.1 RNA Sequence

  2. XR_428715.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    121617558..121641117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)