THBS4 thrombospondin 4 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: THBS4provided by HGNC
Official Full Name: thrombospondin 4provided by HGNC
Primary source: HGNC:11788
See related: Ensembl:ENSG00000113296; HPRD:02836; MIM:600715; Vega:OTTHUMG00000108173
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TSP4
Summary: The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. Studies of the rat counterpart suggest that this protein may be involved in local signaling in the developing and adult nervous system. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 5q13

Sequence :: Chromosome: 5; NC_000005.9 (79331170..79379110)

See THBS4 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of thid study suggested that injury-induced spinal TSP4 may contribute to spinal presynaptic hypersensitivity and neuropathic pain states.
Title: Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states.
genetic polymorphism predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels
Title: Thrombospondin-4 polymorphism (A387P) predicts cardiovascular risk in postinfarction patients with high HDL cholesterol and C-reactive protein levels.
Identify THBS4 as a powerful marker for diffuse-type gastric adenocarcinomas and to provide an initial characterization of its expression in the course of this disease.
Title: THBS4, a novel stromal molecule of diffuse-type gastric adenocarcinomas, identified by transcriptome-wide expression profiling.
High THBS4 methylation resulting in inactivation of the gene is associated with colorectal cancer.
Title: Thrombospondin-4 is a putative tumour-suppressor gene in colorectal cancer that exhibits age-related methylation.
Meta-analysis of gene-disease association. (HuGE Navigator)
Title: Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
The meta-analysis included 6388 (TSP-1), 4930 (TSP-2), and 6978 (TSP-4) cases; none of the polymorphisms was found to be linked with the risk of myocardial infarction.
Title: Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.
Observational study of gene-disease association. (HuGE Navigator)
Title: A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).
Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
Title: Polymorphisms in thrombospondin genes and myocardial infarction: a case-control study and a meta-analysis of available evidence.

Submit: New GeneRIF Correction See all (17)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Pathways from BioSystems

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ECM-receptor interaction, organism-specific biosystem (from KEGG)
ECM-receptor interaction, organism-specific biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
ECM-receptor interaction, conserved biosystem (from KEGG)
ECM-receptor interaction, conserved biosystemThe extracellular matrix (ECM) consists of a complex mixture of structural and functional macromolecules and serves an important role in tissue and organ morphogenesis and in the maintenance of cell ...
Focal Adhesion, organism-specific biosystem (from WikiPathways)
Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Malaria, organism-specific biosystem (from KEGG)
Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
Malaria, conserved biosystem (from KEGG)
Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
Phagosome, organism-specific biosystem (from KEGG)
Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Phagosome, conserved biosystem (from KEGG)
Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by PDGF, organism-specific biosystem (from REACTOME)
Signaling by PDGF, organism-specific biosystemPlatelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary end...

General gene information

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Markers

MARC_15765-15766:1041972257:1 (e-PCR)
- UniSTS:267896

THBS4 (e-PCR)
- UniSTS:504996

SHGC-12514 (e-PCR)
- UniSTS:4078

Homology

Homologs of the THBS4 gene: The THBS4 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
growth factor activity	IEA Inferred from Electronic Annotation more info
heparin binding	IDA Inferred from Direct Assay more info	PubMed
integrin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
endothelial cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
myoblast migration	IDA Inferred from Direct Assay more info	PubMed
negative regulation of angiogenesis	IEP Inferred from Expression Pattern more info	PubMed
positive regulation of cell division	IEA Inferred from Electronic Annotation more info
positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
basement membrane	IDA Inferred from Direct Assay more info	PubMed
extracellular region	TAS Traceable Author Statement more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: thrombospondin-4

Names: thrombospondin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003248.4 → NP_003239.2 thrombospondin-4 precursor

Status: REVIEWED

Source sequence(s)

AC112184, BC050456

Consensus CDS

CCDS4049.1

UniProtKB/Swiss-Prot

P35443

Related

ENSP00000339730, OTTHUMP00000135313, ENST00000350881, OTTHUMT00000226977

Conserved Domains (5) summary

cd00054
Location:379 – 413
Blast Score: 101

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

smart00210
Location:24 – 192
Blast Score: 392

TSPN; Thrombospondin N-terminal -like domains.

pfam05735
Location:745 – 945
Blast Score: 1068

TSP_C; Thrombospondin C-terminal region

pfam11598
Location:218 – 262
Blast Score: 197

COMP; Cartilage oligomeric matrix protein

pfam02412
Location:693 – 727
Blast Score: 106

TSP_3; Thrombospondin type 3 repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p10 Primary Assembly

Range

79331170..79379110

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

74539053..74586983

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018916.1 Alternate CHM1_1.0

Range

79623409..79671314

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01062029.1 (189207..237137)	None
genomic	AC012636.5 (92222..123134)	None
genomic	AC112184.2 (156140..173346)	None
genomic	AMYH01015443.1 (251544..299449)	None
genomic	AY566253.1	AAS66982.1
genomic	CH471084.1	EAW95841.1
mRNA	AK302842.1	BAH13818.1
mRNA	AK313587.1	BAG36356.1
mRNA	BC050456.1	AAH50456.1
mRNA	Z19585.1	CAA79635.1