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    BYSL bystin-like [ Homo sapiens (human) ]

    Gene ID: 705, updated on 5-May-2013
    Official Symbol
    BYSLprovided by HGNC
    Official Full Name
    bystin-likeprovided by HGNC
    Primary source
    HGNC:1157
    Locus tag
    RP5-973N23.2
    See related
    Ensembl:ENSG00000112578; HPRD:04848; MIM:603871; Vega:OTTHUMG00000014687
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BYSTIN
    Summary
    Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi. [provided by RefSeq, Jul 2008]
    Location :
    6p21.1
    Sequence :
    Chromosome: 6; NC_000006.11 (41888965..41900784)
    See BYSL in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 49 Neighboring gene mediator complex subunit 20 Neighboring gene cyclin D3 Neighboring gene TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. Xie Y, et al. J Biol Chem, 2013 Feb 1. PMID 23184937.
    2. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.
    3. A high-throughput approach for measuring temporal changes in the interactome. Kristensen AR, et al. Nat Methods, 2012 Sep. PMID 22863883.
    4. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. Aichem A, et al. J Cell Sci, 2012 Oct 1. PMID 22797925.
    5. Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Tsai YC, et al. Mol Cell Proteomics, 2012 May. PMID 22586326.

    See all (32) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. bystin is necessary for efficient cleavage of the internal transcribed spacer 1 at site 2 and for further processing of the pre-rRNA.
      Title: Analysis of two human pre-ribosomal factors, bystin and hTsr1, highlights differences in evolution of ribosome biogenesis between yeast and mammals.
    2. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
    3. review of the roles of bystin in embryo implantation, assembly of ribosomes, and as a target of c-MYC
      Title: The role of bystin in embryo implantation and in ribosomal biogenesis.
    4. These results suggest that, while bystin may play multiple roles in mammalian cells, a conserved function is to facilitate ribosome biogenesis required for cell growth.
      Title: Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    Q13895 P38432 COIL    HPRD  PubMed  
    Q13895 P05787 KRT8    HPRD  PubMed  
    Q13895 O94972 TRIM37    HPRD  PubMed  
    Q13895 Q12816 TRO    HPRD  PubMed  
    Q13895 Q12815 TROAP    HPRD  PubMed  
    BioGRID:107167 BioGRID:106848 APP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107167 BioGRID:113815 COIL    BioGRID  PubMed Two-hybrid 
    BioGRID:107167 BioGRID:116183 COPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107167 BioGRID:107837 CSNK1D    BioGRID  PubMed Co-fractionation 
    BioGRID:107167 BioGRID:107838 CSNK1E    BioGRID  PubMed Co-fractionation 
    BioGRID:107167 BioGRID:115703 EMG1    BioGRID  PubMed Co-fractionation 
    BioGRID:107167 BioGRID:108378 ERBB4    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:107167 BioGRID:108491 FAU    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107167 BioGRID:114439 HERC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107167 BioGRID:121218 KCMF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107167 BioGRID:110054 KRT8    BioGRID  PubMed Two-hybrid 
    BioGRID:107167 BioGRID:124379 LTV1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107167 BioGRID:121232 PNO1    BioGRID  PubMed Affinity Capture-MS; Co-fractionation 
    BioGRID:107167 BioGRID:112145 RPS26    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107167 BioGRID:112146 RPS27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107167 BioGRID:112102 RPS3    BioGRID  PubMed Co-fractionation 
    BioGRID:107167 BioGRID:119602 SIRT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107167 BioGRID:121411 SMURF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107167 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107167 BioGRID:110678 TRIM37    BioGRID  PubMed Two-hybrid 
    BioGRID:107167 BioGRID:113067 TRO    BioGRID  PubMed Two-hybrid 
    BioGRID:107167 BioGRID:115341 TROAP    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:107167 BioGRID:120842 TSR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107167 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107167 BioGRID:115791 UBD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107167 BioGRID:113255 VCAM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107167 BioGRID:116092 WDR3    BioGRID  PubMed Co-fractionation 
    BioGRID:107167 BioGRID:124031 WIBG    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    female pregnancy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    bystin
    Names
    bystin
    by the ribosomal protein s6 gene, drosophila, homolog-like

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004053.3 → NP_004044.3  bystin

      Status: REVIEWED

      Source sequence(s)
      BC007340, BC050645, BC062627
      Consensus CDS
      CCDS34450.1
      UniProtKB/Swiss-Prot
      Q13895
      Related
      ENSP00000230340, OTTHUMP00000016385, ENST00000230340, OTTHUMT00000040535
      Conserved Domains (1) summary
      pfam05291
      Location:136 – 436
      Blast Score: 1411
      Bystin; Bystin

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p10 Primary Assembly

      Range
      41888965..41900784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      41607755..41619629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018917.1 Alternate CHM1_1.0

      Range
      41799514..41811335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01050744.1 (7813..13924) None
    genomic ABBA01050745.1 None
    genomic AL160163.24 (86800..98619) None
    genomic AMYH01016298.1 (185929..197750) None
    genomic CH471081.1 EAX04069.1
    mRNA AK314147.1 None
    mRNA BC007340.2 AAH07340.3
    mRNA BC050645.1 AAH50645.1
    mRNA BC062627.1 AAH62627.2
    mRNA L36720.2 AAC16603.2
    other-genetic DQ892914.2 ABM83840.1
    other-genetic DQ896163.2 ABM87162.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13895.3 GenPept UniProtKB/Swiss-Prot:Q13895

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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