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Ckap2l cytoskeleton associated protein 2-like [ Mus musculus (house mouse) ]

Gene ID: 70466, updated on 2-Apr-2024

Summary

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Official Symbol
Ckap2lprovided by MGI
Official Full Name
cytoskeleton associated protein 2-likeprovided by MGI
Primary source
MGI:MGI:1917716
See related
Ensembl:ENSMUSG00000048327 AllianceGenome:MGI:1917716
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
rdm; radmis; 2010016H04Rik; 2610318C08Rik
Summary
Predicted to be located in cytoplasm and cytoskeleton. Predicted to be active in centrosome; cytosol; and mitotic spindle. Is expressed in midbrain ventricular layer; nephrogenic zone; olfactory cortex ventricular layer; telencephalon ventricular layer; and thymus primordium. Human ortholog(s) of this gene implicated in Filippi syndrome. Orthologous to human CKAP2L (cytoskeleton associated protein 2 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 7.7), CNS E11.5 (RPKM 7.0) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Ckap2l in Genome Data Viewer
Location:
2 F1; 2 62.87 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (129110130..129139148, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (129268210..129297228, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3404 Neighboring gene solute carrier family 20, member 1 Neighboring gene RIKEN cDNA A730036I17 gene Neighboring gene STARR-seq mESC enhancer starr_05664 Neighboring gene STARR-seq mESC enhancer starr_05666 Neighboring gene STARR-positive B cell enhancer ABC_E5981 Neighboring gene STARR-positive B cell enhancer ABC_E7862 Neighboring gene STARR-seq mESC enhancer starr_05668 Neighboring gene predicted gene 14023 Neighboring gene interleukin 1 alpha Neighboring gene predicted gene, 29941 Neighboring gene predicted gene, 25703

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutations in CKAP2L, the human homolog of the mouse Radmis gene, cause Filippi syndrome. Hussain MS, et al. Am J Hum Genet, 2014 Nov 6. PMID 25439729, Free PMC Article
  2. Radmis, a novel mitotic spindle protein that functions in cell division of neural progenitors. Yumoto T, et al. PLoS One, 2013. PMID 24260314, Free PMC Article
  3. Ttyh1, a Ca(2+)-binding protein localized to the endoplasmic reticulum, is required for early embryonic development. Kumada T, et al. Dev Dyn, 2010 Aug. PMID 20568244
  4. The LMO2 oncogene regulates DNA replication in hematopoietic cells. Sincennes MC, et al. Proc Natl Acad Sci U S A, 2016 Feb 2. PMID 26764384, Free PMC Article
  5. Gene discovery by microarray: identification of novel genes induced during growth factor-mediated muscle cell survival and differentiation. Kuninger D, et al. Genomics, 2004 Nov. PMID 15475267

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytoskeleton-associated protein 2-like
Names
radial fiber and mitotic spindle protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181589.3 → NP_853620.1  cytoskeleton-associated protein 2-like

    See identical proteins and their annotated locations for NP_853620.1

    Status: VALIDATED

    Source sequence(s)
    AL772347, BC053443, CO042920, CV560846, CX205381
    Consensus CDS
    CCDS16724.1
    UniProtKB/Swiss-Prot
    Q3U5A3, Q7TS74, Q8K264, U6C6D6
    Related
    ENSMUSP00000056145.7, ENSMUST00000052708.7
    Conserved Domains (1) summary
    pfam15297
    Location:435 → 734
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    129110130..129139148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500158.5 → XP_006500221.1  cytoskeleton-associated protein 2-like isoform X1

    Conserved Domains (1) summary
    pfam15297
    Location:436 → 733
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

  2. XM_030252067.2 → XP_030107927.1  cytoskeleton-associated protein 2-like isoform X2

    Conserved Domains (1) summary
    pfam15297
    Location:387 → 685
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus

  3. XM_036162563.1 → XP_036018456.1  cytoskeleton-associated protein 2-like isoform X3

    Conserved Domains (1) summary
    pfam15297
    Location:387 → 684
    CKAP2_C; Cytoskeleton-associated protein 2 C-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TS74.1 GenPept UniProtKB/Swiss-Prot:Q7TS74

Gene LinkOut

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