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TFF3 trefoil factor 3 [ Homo sapiens (human) ]

Gene ID: 7033, updated on 26-May-2016
Official Symbol
TFF3provided by HGNC
Official Full Name
trefoil factor 3provided by HGNC
Primary source
HGNC:HGNC:11757
See related
Ensembl:ENSG00000160180 HPRD:02797; MIM:600633; Vega:OTTHUMG00000086798
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ITF; P1B; TFI
Summary
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]
Orthologs
Location:
21q22.3
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 21 NC_000021.9 (42311667..42315596, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (43731777..43735706, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uromodulin like 1 Neighboring gene UMODL1 antisense RNA 1 Neighboring gene uncharacterized LOC105372814 Neighboring gene ATP binding cassette subfamily G member 1 Neighboring gene RNA, 5S ribosomal pseudogene 492 Neighboring gene uncharacterized LOC105372815 Neighboring gene trefoil factor 2 Neighboring gene trefoil factor 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
defense response TAS
Traceable Author Statement
more info
PubMed 
digestion TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
trefoil factor 3
Names
polypeptide P1.B
trefoil factor 3 (intestinal)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003226.3NP_003217.3  trefoil factor 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AF432265, AP001623, BC017859
    Consensus CDS
    CCDS33565.2
    UniProtKB/Swiss-Prot
    Q07654
    UniProtKB/TrEMBL
    A0A0A6YYJ4
    Related
    ENSP00000430690, OTTHUMP00000109348, ENST00000518498, OTTHUMT00000195358
    Conserved Domains (1) summary
    cd00111
    Location:4486
    Trefoil; P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p2 Primary Assembly

    Range
    42311667..42315596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018932.2 Alternate CHM1_1.1

    Range
    43291988..43295917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)