NR2F1 nuclear receptor subfamily 2, group F, member 1 [Homo sapiens] - Gene

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Summary

Official Symbol: NR2F1provided by HGNC
Official Full Name: nuclear receptor subfamily 2, group F, member 1provided by HGNC
Primary source: HGNC:7975
See related: Ensembl:ENSG00000175745; HPRD:00584; MIM:132890; Vega:OTTHUMG00000119079
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EAR3; EAR-3; NR2F2; SVP44; ERBAL3; TFCOUP1; COUP-TFI; TCFCOUP1

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Genomic context

Location :: 5q14

Sequence :: Chromosome: 5; NC_000005.9 (92919043..92929788)

See NR2F1 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study identifies two unique corticotroph tumor populations which differ in their expression of COUP-TFI, the presence of which occurs more frequently in macroadenomas.
Title: Immunohistochemistry of COUP-TFI: an adjuvant diagnostic tool for the identification of corticotroph microadenomas.
provide detailed experimental validation of each step and, as a proof of principle, utilize the methodology to identify novel direct targets of the orphan nuclear receptor NR2F1 (COUP-TFI)
Title: Genome-wide analysis of binding sites and direct target genes of the orphan nuclear receptor NR2F1/COUP-TFI.
Transcriptional and posttranscriptional mechanisms involving NR2F1 and IRE1beta ensure low microsomal triglyceride transfer protein expression in undifferentiated intestinal cells and avoid apolipoprotein B lipoprotein biosynthesis.
Title: NR2F1 and IRE1beta suppress microsomal triglyceride transfer protein expression and lipoprotein assembly in undifferentiated intestinal epithelial cells.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: A three-stage genome-wide association study of general cognitive ability: hunting the small effects.
Observational study of gene-disease association. (HuGE Navigator)
Title: The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.
A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8).
Title: A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8).
COUP-TFI selectively regulates the expression of endogenous E2-target genes and consequently modifies ER alpha positive mammary cells response to E2.
Title: COUP-TFI modulates estrogen signaling and influences proliferation, survival and migration of breast cancer cells.
Regulation of vascular endothelial growth factor D by hepatocyte nuclear factor-4 alpha and chicken ovalbumin upstream promoter transcription factors 1 and 2.
Title: Regulation of vascular endothelial growth factor D by orphan receptors hepatocyte nuclear factor-4 alpha and chicken ovalbumin upstream promoter transcription factors 1 and 2.
Transcription of the LHR gene is repressed by EAR3.
Title: Repression of the luteinizing hormone receptor gene promoter by cross talk among EAR3/COUP-TFI, Sp1/Sp3, and TFIIB.
Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor.
Title: Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor.

Submit: New GeneRIF Correction See all (15)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Through amino acids 49-148, COUP-TF physically interacts with amino acids 48-72 of HIV-1 Tat, allowing COUP-TF to cooperate with Tat during transactivation of the HIV-1 LTR promoter	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
P10589	P35869	AHR	HPRD	PubMed
P10589	Q9H165	BCL11A	HPRD	PubMed
P10589	Q9C0K0	BCL11B	HPRD	PubMed
P10589	P61201	COPS2	HPRD	PubMed
P10589	P29692	EEF1D	HPRD	PubMed
P10589	P03372	ESR1	HPRD	PubMed
P10589	Q00403	GTF2B	HPRD	PubMed
P10589	P41235	HNF4A	HPRD	PubMed
P10589	P61371	ISL1	HPRD	PubMed
P10589	Q6P3T0	MAP6	HPRD	PubMed
P10589	Q15788	NCOA1	HPRD	PubMed
P10589	Q9Y618	NCOR2	HPRD	PubMed
P10589	P19793	RXRA	HPRD	PubMed
P10589	P08047	SP1	HPRD	PubMed
P10589	P10827	THRA	HPRD	PubMed
BioGRID:112883	BioGRID:106699	AHR	BioGRID	PubMed	Reconstituted Complex
BioGRID:112883	BioGRID:119737	BCL11A	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:112883	BioGRID:122343	BCL11B	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:112883	BioGRID:117030	CBX5	BioGRID	PubMed	Reconstituted Complex
BioGRID:112883	BioGRID:114729	COPS2	BioGRID	PubMed	Reconstituted Complex
BioGRID:112883	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:112883	BioGRID:116995	GRIP1	BioGRID	PubMed	Two-hybrid
BioGRID:112883	BioGRID:109214	GTF2B	BioGRID	PubMed	Reconstituted Complex
BioGRID:112883	BioGRID:109877	ISL1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112883	BioGRID:113841	NCOA3	BioGRID	PubMed	Two-hybrid
BioGRID:112883	BioGRID:111223	PFDN1	BioGRID	PubMed	Two-hybrid
BioGRID:112883	BioGRID:116459	PHB2	BioGRID	PubMed	Reconstituted Complex
BioGRID:112883	BioGRID:112550	SP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112883	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
receptor activity	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
steroid hormone receptor activity	IEA Inferred from Electronic Annotation more info
transcription coactivator activity	TAS Traceable Author Statement more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
forebrain development	IEA Inferred from Electronic Annotation more info
gene expression	TAS Traceable Author Statement more info
intracellular receptor mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
neuron migration	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	TAS Traceable Author Statement more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: COUP transcription factor 1

Names: COUP transcription factor 1; COUP-TF1; COUP-TF I; V-erbA-related protein 3; COUP transcription factor I; chicken ovalbumin upstream promoter-transcription factor I; transcription factor COUP 1 (chicken ovalbumin upstream promoter 1, v-erb-a homolog-like 3)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005654.4 → NP_005645.1 COUP transcription factor 1

Status: PROVISIONAL

Source sequence(s)

BC017493

Consensus CDS

CCDS4068.1

UniProtKB/Swiss-Prot

P10589

Related

ENSP00000325819, OTTHUMP00000147621, ENST00000327111, OTTHUMT00000239293

Conserved Domains (2) summary

cd06948
Location:184 – 419
Blast Score: 1247

NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

cd06958
Location:86 – 158
Blast Score: 429

NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

92919043..92929788

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

88092169..88102739

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC106818.2 (50710..61455)	None
genomic	CH471084.1	EAW96008.1
		EAW96009.1
genomic	X12795.1	CAA31283.1
mRNA	BC004154.2	AAH04154.1
mRNA	BC017493.1	AAH17493.1
mRNA	HQ709180.1	ADZ17387.1
mRNA	HQ709182.1	ADZ17389.1
mRNA	HQ709183.1	ADZ17390.1
mRNA	X16155.1	CAA34277.1