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Nars1 asparaginyl-tRNA synthetase 1 [ Mus musculus (house mouse) ]

Gene ID: 70223, updated on 11-Apr-2024

Summary

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Official Symbol
Nars1provided by MGI
Official Full Name
asparaginyl-tRNA synthetase 1provided by MGI
Primary source
MGI:MGI:1917473
See related
Ensembl:ENSMUSG00000024587 AllianceGenome:MGI:1917473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nars; ASNRS; 3010001M15Rik
Summary
Predicted to enable CCR3 chemokine receptor binding activity; asparagine-tRNA ligase activity; and protein dimerization activity. Predicted to be involved in asparaginyl-tRNA aminoacylation; cell migration; and cerebral cortex development. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human NARS1 (asparaginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 51.7), placenta adult (RPKM 44.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nars1 in Genome Data Viewer
Location:
18 E1; 18 37.47 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (64632726..64649586, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (64499655..64516515, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine decarboxylase, pseudogene 3 Neighboring gene ferrochelatase Neighboring gene STARR-seq mESC enhancer starr_44807 Neighboring gene STARR-positive B cell enhancer ABC_E10997 Neighboring gene STARR-positive B cell enhancer ABC_E8722 Neighboring gene STARR-seq mESC enhancer starr_44809 Neighboring gene ATPase, class I, type 8B, member 1 Neighboring gene predicted gene 6978 Neighboring gene STARR-seq mESC enhancer starr_44810 Neighboring gene STARR-seq mESC enhancer starr_44811 Neighboring gene predicted gene, 23016

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fibroblast growth factor 2-induced cytoplasmic asparaginyl-tRNA synthetase promotes survival of osteoblasts by regulating anti-apoptotic PI3K/Akt signaling. Park SJ, et al. Bone, 2009 Nov. PMID 19631775
  2. Inactivation of the 3-phosphoglycerate dehydrogenase gene in mice: changes in gene expression and associated regulatory networks resulting from serine deficiency. Furuya S, et al. Funct Integr Genomics, 2008 Aug. PMID 18228065
  3. A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis. Laguesse S, et al. Dev Cell, 2015 Dec 7. PMID 26651292
  4. Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency. Guan N, et al. Kidney Int, 2022 Jul. PMID 35341793, Free PMC Article
  5. The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4. Ahn Y, et al. Biochem J, 2008 Jun 1. PMID 18307411

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NARS is one of the important mediators of FGF2 induced survival signaling in osteoblasts through the activation of PI3K/Akt survival pathway.
    Title: Fibroblast growth factor 2-induced cytoplasmic asparaginyl-tRNA synthetase promotes survival of osteoblasts by regulating anti-apoptotic PI3K/Akt signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CCR3 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables asparagine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asparagine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in asparaginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in asparaginyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebral cortex development ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
asparagine--tRNA ligase, cytoplasmic
Names
asparaginyl-tRNA synthetase, cytoplasmic
NP_001136422.2
NP_001363950.1
NP_001363951.1
NP_001363952.1
NP_081626.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142950.2 → NP_001136422.2  asparagine--tRNA ligase, cytoplasmic isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102268
    Consensus CDS
    CCDS50308.1
    UniProtKB/Swiss-Prot
    Q3T9A7, Q7TPX0, Q8BP47, Q9CRY5
    Related
    ENSMUSP00000157402.2, ENSMUST00000237400.2
    Conserved Domains (1) summary
    COG0017
    Location:125 → 548
    AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  2. NM_001377021.1 → NP_001363950.1  asparagine--tRNA ligase, cytoplasmic isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC102268
    UniProtKB/Swiss-Prot
    Q3T9A7, Q7TPX0, Q8BP47, Q9CRY5
    Conserved Domains (1) summary
    COG0017
    Location:126 → 549
    AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  3. NM_001377022.1 → NP_001363951.1  asparagine--tRNA ligase, cytoplasmic isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC102268
    UniProtKB/Swiss-Prot
    Q3T9A7, Q7TPX0, Q8BP47, Q9CRY5
    Conserved Domains (1) summary
    COG0017
    Location:125 → 546
    AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  4. NM_001377023.1 → NP_001363952.1  asparagine--tRNA ligase, cytoplasmic isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC102268
    UniProtKB/TrEMBL
    A0A494BAX5
    Related
    ENSMUSP00000158278.2, ENSMUST00000237351.2
    Conserved Domains (1) summary
    COG0017
    Location:95 → 518
    AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

  5. NM_027350.4 → NP_081626.3  asparagine--tRNA ligase, cytoplasmic isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102268
    Consensus CDS
    CCDS89261.1
    UniProtKB/TrEMBL
    A0A498WGK2
    Related
    ENSMUSP00000025483.11, ENSMUST00000025483.11
    Conserved Domains (1) summary
    COG0017
    Location:124 → 547
    AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    64632726..64649586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BP47.2 GenPept UniProtKB/Swiss-Prot:Q8BP47

Gene LinkOut

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