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TECTA tectorin alpha [ Homo sapiens (human) ]

Gene ID: 7007, updated on 19-Jul-2014
Official Symbol
TECTAprovided by HGNC
Official Full Name
tectorin alphaprovided by HGNC
Primary source
HGNC:11720
See related
Ensembl:ENSG00000109927; HPRD:03985; MIM:602574; Vega:OTTHUMG00000149908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DFNA8; DFNA12; DFNB21
Summary
The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008]
See TECTA in Epigenomics, MapViewer
Location:
11q22-q24
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (121102666..121191493)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (120973375..121062202)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glutamate receptor, ionotropic, kainate 4 Neighboring gene high mobility group box 1 pseudogene 42 Neighboring gene tubulin folding cofactor E-like Neighboring gene ribosomal protein S4X pseudogene 12 Neighboring gene sterol-C5-desaturase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
sensory perception of sound IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
proteinaceous extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
alpha-tectorin
Names
alpha-tectorin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011633.1 

    Range
    5001..93141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005422.2NP_005413.2  alpha-tectorin precursor

    See proteins identical to NP_005413.2

    Status: REVIEWED

    Source sequence(s)
    AP000646, AP000826
    Consensus CDS
    CCDS8434.1
    UniProtKB/Swiss-Prot
    O75443
    Related
    ENSP00000264037, ENST00000264037
    Conserved Domains (8) summary
    pfam12714
    Location:652706
    Blast Score: 107
    TILa; TILa domain
    smart00216
    Location:313477
    Blast Score: 402
    VWD; von Willebrand factor (vWF) type D domain
    smart00241
    Location:18052057
    Blast Score: 529
    ZP; Zona pellucida (ZP) domain
    smart00539
    Location:98254
    Blast Score: 560
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00832
    Location:517591
    Blast Score: 251
    C8; This domain contains 8 conserved cysteine residues
    pfam01826
    Location:597650
    Blast Score: 167
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12941368
    Blast Score: 224
    C8; C8 domain
    pfam14670
    Location:20892121
    Blast Score: 105
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    121102666..121191493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271653.1XP_005271710.1  

    Conserved Domains (8) summary
    pfam12714
    Location:652706
    Blast Score: 107
    TILa; TILa domain
    smart00216
    Location:313477
    Blast Score: 401
    VWD; von Willebrand factor (vWF) type D domain
    smart00241
    Location:18002052
    Blast Score: 529
    ZP; Zona pellucida (ZP) domain
    smart00539
    Location:98254
    Blast Score: 560
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    smart00832
    Location:517591
    Blast Score: 251
    C8; This domain contains 8 conserved cysteine residues
    pfam01826
    Location:597650
    Blast Score: 167
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:12941368
    Blast Score: 224
    C8; C8 domain
    pfam14670
    Location:20842116
    Blast Score: 105
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    116913441..117001973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    120860789..120948696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)