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PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 [ Homo sapiens (human) ]

Gene ID: 6992, updated on 8-May-2016
Official Symbol
PPP1R11provided by HGNC
Official Full Name
protein phosphatase 1 regulatory inhibitor subunit 11provided by HGNC
Primary source
HGNC:HGNC:9285
See related
Ensembl:ENSG00000204619 HPRD:09449; MIM:606670; Vega:OTTHUMG00000031260
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCGV; IPP3; HCG-V; TCTE5; TCTEX5; CFAP255
Summary
This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]
Orthologs
Location:
6p21.3
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (30066880..30070333)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30034932..30038110)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene zinc ribbon domain containing 1 antisense, pseudogene Neighboring gene eukaryotic translation termination factor 1 pseudogene 1 Neighboring gene zinc ribbon domain containing 1 Neighboring gene ring finger protein 39 Neighboring gene TRIM31 antisense RNA 1 Neighboring gene tripartite motif containing 31 Neighboring gene tripartite motif containing 40

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
NHGRI GWA Catalog
Genome-wide association study of proneness to anger.
NHGRI GWA Catalog
Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).
NHGRI GWA Catalog
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC125741, MGC125742, MGC125743

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
negative regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
protein phosphatase type 1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
protein phosphatase 1 regulatory subunit 11
Names
HCG V
hemochromatosis candidate gene V protein
inhibitor-3
protein phosphatase 1, regulatory (inhibitor) subunit 11
protein phosphatase 1, regulatory (inhibitor) subunit 11, isoform 1
protein phosphatase inhibitor 3
t-complex-associated-testis-expressed 5
NP_068778.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021959.2NP_068778.1  protein phosphatase 1 regulatory subunit 11

    See identical proteins and their annotated locations for NP_068778.1

    Status: REVIEWED

    Source sequence(s)
    AL669914, CB126242
    Consensus CDS
    CCDS4671.1
    UniProtKB/Swiss-Prot
    O60927
    UniProtKB/TrEMBL
    A2BEK1
    Related
    ENSP00000365963, OTTHUMP00000029382, ENST00000376772, OTTHUMT00000076557
    Conserved Domains (1) summary
    pfam07491
    Location:2971
    PPI_Ypi1; Protein phosphatase inhibitor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    30066880..30070333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715174.2XP_006715237.1  

    See identical proteins and their annotated locations for XP_006715237.1

    Conserved Domains (1) summary
    pfam07491
    Location:1860
    PPI_Ypi1; Protein phosphatase inhibitor

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    1324972..1328425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725042.2XP_006725105.1  

    See identical proteins and their annotated locations for XP_006725105.1

    Conserved Domains (1) summary
    pfam07491
    Location:1860
    PPI_Ypi1; Protein phosphatase inhibitor

Reference GRCh38.p2 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p2 ALT_REF_LOCI_2

    Range
    1546651..1550104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725499.2XP_006725562.1  

    See identical proteins and their annotated locations for XP_006725562.1

    Conserved Domains (1) summary
    pfam07491
    Location:1860
    PPI_Ypi1; Protein phosphatase inhibitor

Reference GRCh38.p2 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p2 ALT_REF_LOCI_3

    Range
    1322796..1326249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725713.2XP_006725776.1  

    See identical proteins and their annotated locations for XP_006725776.1

    Conserved Domains (1) summary
    pfam07491
    Location:1860
    PPI_Ypi1; Protein phosphatase inhibitor

Reference GRCh38.p2 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p2 ALT_REF_LOCI_4

    Range
    1327904..1331083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005275158.3XP_005275215.1  

    See identical proteins and their annotated locations for XP_005275215.1

    Conserved Domains (1) summary
    pfam07491
    Location:1860
    PPI_Ypi1; Protein phosphatase inhibitor

Reference GRCh38.p2 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p2 ALT_REF_LOCI_5

    Range
    1410970..1414423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006725921.2XP_006725984.1  

    See identical proteins and their annotated locations for XP_006725984.1

    Conserved Domains (1) summary
    pfam07491
    Location:1860
    PPI_Ypi1; Protein phosphatase inhibitor

Reference GRCh38.p2 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p2 ALT_REF_LOCI_6

    Range
    1322040..1325493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006726016.2XP_006726079.1  

    See identical proteins and their annotated locations for XP_006726079.1

    Conserved Domains (1) summary
    pfam07491
    Location:1860
    PPI_Ypi1; Protein phosphatase inhibitor

Reference GRCh38.p2 ALT_REF_LOCI_7

Genomic

  1. NT_167249.2 Reference GRCh38.p2 ALT_REF_LOCI_7

    Range
    1365799..1369252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006726110.2XP_006726173.1  

    See identical proteins and their annotated locations for XP_006726173.1

    Conserved Domains (1) summary
    pfam07491
    Location:1860
    PPI_Ypi1; Protein phosphatase inhibitor

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    30036981..30040159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_170781.1: Suppressed sequence

    Description
    NM_170781.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.