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    PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 [ Homo sapiens (human) ]

    Gene ID: 6992, updated on 5-May-2013
    Official Symbol
    PPP1R11provided by HGNC
    Official Full Name
    protein phosphatase 1, regulatory (inhibitor) subunit 11provided by HGNC
    Primary source
    HGNC:9285
    Locus tag
    DAAP-65D20.5
    See related
    Ensembl:ENSG00000204619; HPRD:09449; MIM:606670; Vega:OTTHUMG00000031260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCGV; IPP3; HCG-V; TCTE5; TCTEX5
    Summary
    This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]
    Location :
    6p21.3
    Sequence :
    Chromosome: 6; NC_000006.11 (30034932..30038110)
    See PPP1R11 in Epigenomics

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene ZNRD1 antisense RNA 1 Neighboring gene eukaryotic translation termination factor 1 pseudogene 1 Neighboring gene zinc ribbon domain containing 1 Neighboring gene ring finger protein 39 Neighboring gene tripartite motif containing 31 Neighboring gene tripartite motif containing 40

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Kettunen J, et al. Nat Genet, 2012 Jan 29. PMID 22286219.
    2. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068.
    3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. Barcellos LF, et al. PLoS Genet, 2009 Oct. PMID 19851445.
    4. Identification of the interaction sites of Inhibitor-3 for protein phosphatase-1. Zhang L, et al. Biochem Biophys Res Commun, 2008 Dec 12. PMID 18951879.
    5. Protein phosphatase-1 inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response. Huang HS, et al. J Biol Chem, 2008 Jun 27. PMID 18450750.

    See all (20) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.
    2. Inh3 has two domains that are required for its interaction with PP1.
      Title: Identification of the interaction sites of Inhibitor-3 for protein phosphatase-1.
    3. inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response
      Title: Protein phosphatase-1 inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response.
    4. Sds22 and Inhibitor-3 form a heterotrimeric complex with PP1, both in cell lysates and after purification. A pool of PP1 is complexly controlled by both Sds22 and Inhibitor-3.
      Title: A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    O60927 P62136 PPP1CA    HPRD  PubMed  
    BioGRID:112852 BioGRID:216776 Cep72    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112852 BioGRID:111494 PPP1CB    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Homology

    Clone Names

    • MGC125741, MGC125742, MGC125743

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Preferred Names
    protein phosphatase 1 regulatory subunit 11
    Names
    protein phosphatase 1 regulatory subunit 11
    HCG V
    inhibitor-3
    protein phosphatase inhibitor 3
    t-complex-associated-testis-expressed 5
    hemochromatosis candidate gene V protein
    protein phosphatase 1, regulatory (inhibitor) subunit 11, isoform 1
    NP_068778.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021959.2 → NP_068778.1  protein phosphatase 1 regulatory subunit 11

      Status: REVIEWED

      Source sequence(s)
      AL669914, CB126242
      Consensus CDS
      CCDS4671.1
      UniProtKB/TrEMBL
      A2BEK1
      UniProtKB/Swiss-Prot
      O60927
      Related
      ENSP00000365963, OTTHUMP00000029382, ENST00000376772, OTTHUMT00000076557
      Conserved Domains (1) summary
      pfam07491
      Location:29 – 71
      Blast Score: 157
      PPI_Ypi1; Protein phosphatase inhibitor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.1 Reference GRCh37.p10 ALT_REF_LOCI_1

      Range
      1275163..1278341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.2 Reference GRCh37.p10 ALT_REF_LOCI_2

      Range
      1547032..1550210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.1 Reference GRCh37.p10 ALT_REF_LOCI_3

      Range
      1328656..1331834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.1 Reference GRCh37.p10 ALT_REF_LOCI_4

      Range
      1333524..1336703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.1 Reference GRCh37.p10 ALT_REF_LOCI_5

      Range
      1416830..1420008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.1 Reference GRCh37.p10 ALT_REF_LOCI_6

      Range
      1327911..1331089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.1 Reference GRCh37.p10 ALT_REF_LOCI_7

      Range
      1365372..1368550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p10 Primary Assembly

      Range
      30034932..30038110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      29833104..29836282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018917.1 Alternate CHM1_1.0

      Range
      29949147..29952325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_170781.1: Suppressed sequence

      Description
      NM_170781.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    genomic AB088087.1 BAC54919.1
    genomic AB202082.1 BAE78601.1
    genomic ABBA01038041.1 (97560..100738) None
    genomic AL669914.2 (61787..64966) None
    genomic AL671859.3 (46751..49929) None
    genomic AL845439.5 (41937..45115) None
    genomic AMYH01016204.1 (169146..172324) None
    genomic BA000025.2 BAB63334.1
    genomic BX088647.3 (60775..63953) None
    genomic BX927229.6 (98431..101610) None
    genomic CH471081.1 EAX03253.1
      EAX03254.1
    genomic CR388205.7 (94106..97284) None
    genomic CR759763.2 (86537..89715) None
    genomic CR759960.3 (64318..67496) None
    genomic U53588.1 AAC52082.1
    genomic X89902.1 CAC16919.1
    mRNA AF070599.1 None
    mRNA AK310593.1 None
    mRNA AK313175.1 BAG35992.1
    mRNA BC003144.1 AAH03144.1
    mRNA BC102010.1 AAI02011.1
    mRNA BC102011.1 AAI02012.1
    mRNA BC104750.1 AAI04751.1
    mRNA CB126242.1 None
    mRNA X81003.1 CAC16920.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60927.1 GenPept UniProtKB/Swiss-Prot:O60927

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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