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Dapk1 death associated protein kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 69635, updated on 28-May-2016
Official Symbol
Dapk1provided by MGI
Official Full Name
death associated protein kinase 1provided by MGI
Primary source
MGI:MGI:1916885
See related
Ensembl:ENSMUSG00000021559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D13Ucla1; DAP-Kinase
Orthologs
Location:
13 B2; 13 32.53 cM
Exon count:
29
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (60601947..60763191)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (60703308..60864547)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530001N23 gene Neighboring gene predicted gene, 40973 Neighboring gene predicted gene, 40974 Neighboring gene predicted gene, 35540 Neighboring gene predicted gene 10312 Neighboring gene cDNA sequence BC051665

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • 2310039H24Rik, 2810425C21Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
syntaxin-1 binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cellular response to interferon-gamma IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
PubMed 
extrinsic apoptotic signaling pathway via death domain receptors IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of N-methyl-D-aspartate selective glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
death-associated protein kinase 1
Names
DAP kinase 1
NP_001272846.1
NP_083929.2
NP_598823.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285917.1NP_001272846.1  death-associated protein kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001272846.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154176, AK145922, BC060161, BQ745486, CT010498, CX244175
    UniProtKB/Swiss-Prot
    Q80YE7
    UniProtKB/TrEMBL
    Q3UKP8
    Conserved Domains (6) summary
    smart00220
    Location:13275
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00204
    Location:439564
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:449541
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:347399
    Ank_4; Ankyrin repeats (many copies)
    cd08782
    Location:13081393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
  2. NM_029653.3NP_083929.2  death-associated protein kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_083929.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC154176, AK145922, BC060161, BQ745486, CT010498, CX244175
    Consensus CDS
    CCDS26581.1
    UniProtKB/Swiss-Prot
    Q80YE7
    UniProtKB/TrEMBL
    Q3UKP8
    Related
    ENSMUSP00000076666, ENSMUST00000077453
    Conserved Domains (6) summary
    smart00220
    Location:13275
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00204
    Location:439564
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:449541
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:347399
    Ank_4; Ankyrin repeats (many copies)
    cd08782
    Location:13081393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
  3. NM_134062.2NP_598823.1  death-associated protein kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_598823.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 3' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK145922, BC060161, BQ745486, CT010498
    Consensus CDS
    CCDS26581.1
    UniProtKB/Swiss-Prot
    Q80YE7
    UniProtKB/TrEMBL
    Q3UKP8
    Related
    ENSMUSP00000040825, ENSMUST00000044083
    Conserved Domains (6) summary
    smart00220
    Location:13275
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00204
    Location:439564
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:449541
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:347399
    Ank_4; Ankyrin repeats (many copies)
    cd08782
    Location:13081393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

    Range
    60601947..60763191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517370.2XP_006517433.1  

    See identical proteins and their annotated locations for XP_006517433.1

    UniProtKB/Swiss-Prot
    Q80YE7
    Conserved Domains (6) summary
    smart00220
    Location:13275
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00204
    Location:439564
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:449541
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:347399
    Ank_4; Ankyrin repeats (many copies)
    cd08782
    Location:13081393
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cd14194
    Location:7275
    STKc_DAPK1; Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1
  2. XM_006517371.2XP_006517434.2  

    Conserved Domains (6) summary
    smart00220
    Location:2256
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00204
    Location:420545
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:430522
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:328380
    Ank_4; Ankyrin repeats (many copies)
    cd08782
    Location:12891374
    Death_DAPK1; Death domain found in death-associated protein kinase 1
    cl21453
    Location:2256
    PKc_like; Protein Kinases, catalytic domain

Alternate Mm_Celera

Genomic

  1. AC_000035.1 Alternate Mm_Celera

    Range
    61661141..61823112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)