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    TRA@ T cell receptor alpha locus [ Homo sapiens ]

    Gene ID: 6955, updated on 11-May-2012
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    Summary

    Official Symbol
    TRA@provided by HGNC
    Official Full Name
    T cell receptor alpha locusprovided by HGNC
    Primary source
    HGNC:12027
    See related
    MIM:186880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRA; TCRA; TCRD; FLJ22602; MGC22624; MGC23964; MGC71411; MGC117436
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    Genomic context

    Location :
    14q11.2
    Sequence :
    Chromosome: 14; NC_000014.8 (22090057..23021075)
    See TRA@ in Epigenomics, MapViewer

    Chromosome 14 - NC_000014.8Genomic Context describing neighboring genes Neighboring gene olfactory receptor, family 10, subfamily G, member 1 pseudogene Neighboring gene ubiquitin-conjugating enzyme E2N pseudogene 1 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 pseudogene 1 Neighboring gene T cell receptor alpha variable 1-1 Neighboring gene T cell receptor alpha variable 1-2 Neighboring gene olfactory receptor, family 10, subfamily G, member 2 Neighboring gene olfactory receptor, family 4, subfamily E, member 2 Neighboring gene olfactory receptor, family 4, subfamily E, member 1 (gene/pseudogene) Neighboring gene T cell receptor alpha variable 2 Neighboring gene T cell receptor alpha variable 3 (gene/pseudogene) Neighboring gene T cell receptor alpha variable 4 Neighboring gene ribosomal protein L4 pseudogene 1 Neighboring gene T cell receptor alpha variable 5 Neighboring gene T cell receptor alpha variable 6 Neighboring gene T cell receptor alpha variable 8-1 Neighboring gene T cell receptor alpha variable 9-1 Neighboring gene T cell receptor alpha variable 7 Neighboring gene T cell receptor alpha variable 12-1 Neighboring gene T cell receptor alpha variable 10 Neighboring gene T cell receptor alpha variable 11 (pseudogene) Neighboring gene T cell receptor alpha variable 8-2 Neighboring gene T cell receptor alpha variable 8-3 Neighboring gene T cell receptor alpha variable 13-1 Neighboring gene T cell receptor alpha variable 12-2 Neighboring gene T cell receptor alpha variable 14/delta variable 4 Neighboring gene T cell receptor alpha variable 8-4 Neighboring gene T cell receptor alpha variable 8-5 (pseudogene) Neighboring gene T cell receptor alpha variable 13-2 Neighboring gene T cell receptor alpha variable 9-2 Neighboring gene T cell receptor alpha variable 12-3 Neighboring gene T cell receptor alpha variable 15 (pseudogene) Neighboring gene T cell receptor alpha variable 8-6 Neighboring gene T cell receptor alpha variable 16 Neighboring gene T cell receptor alpha variable 17 Neighboring gene T cell receptor alpha variable 18 Neighboring gene T cell receptor alpha variable 19 Neighboring gene T cell receptor alpha variable 20 Neighboring gene T cell receptor alpha variable 23/delta variable 6 Neighboring gene T cell receptor alpha variable 21 Neighboring gene T cell receptor alpha variable 22 Neighboring gene T cell receptor alpha variable 26-1 Neighboring gene T cell receptor alpha variable 24 Neighboring gene T cell receptor delta variable 1 Neighboring gene T cell receptor alpha variable 25 Neighboring gene T cell receptor alpha variable 8-7 (non-functional) Neighboring gene T cell receptor alpha variable 29/delta variable 5 (gene/pseudogene) Neighboring gene T cell receptor alpha variable 27 Neighboring gene T cell receptor alpha variable 28 (pseudogene) Neighboring gene T cell receptor alpha variable 30 Neighboring gene T cell receptor alpha variable 26-2 Neighboring gene T cell receptor alpha variable 31 (pseudogene) Neighboring gene T cell receptor alpha variable 36/delta variable 7 Neighboring gene T cell receptor alpha variable 32 (pseudogene) Neighboring gene T cell receptor alpha variable 33 (pseudogene) Neighboring gene T cell receptor alpha variable 34 Neighboring gene T cell receptor alpha variable 38-2/delta variable 8 Neighboring gene T cell receptor alpha variable 35 Neighboring gene T cell receptor alpha variable 38-1 Neighboring gene T cell receptor alpha variable 37 (pseudogene) Neighboring gene T cell receptor alpha variable 39 Neighboring gene T cell receptor alpha variable 40 Neighboring gene T cell receptor alpha variable 41 Neighboring gene T cell receptor delta variable 2 Neighboring gene T cell receptor delta locus Neighboring gene T cell receptor delta diversity 1 Neighboring gene T cell receptor delta diversity 2 Neighboring gene T cell receptor delta diversity 3 Neighboring gene T cell receptor delta joining 1 Neighboring gene T cell receptor delta joining 4 Neighboring gene T cell receptor delta joining 2 Neighboring gene T cell receptor delta joining 3 Neighboring gene T cell receptor alpha joining 61 (non-functional) Neighboring gene T cell receptor alpha joining 60 (pseudogene) Neighboring gene T cell receptor alpha joining 59 (non-functional) Neighboring gene T cell receptor alpha joining 58 (non-functional) Neighboring gene T cell receptor alpha joining 57 Neighboring gene T cell receptor alpha joining 56 Neighboring gene T cell receptor delta variable 3 Neighboring gene T cell receptor alpha joining 55 (pseudogene) Neighboring gene T cell receptor alpha joining 54 Neighboring gene T cell receptor alpha joining 53 Neighboring gene T cell receptor alpha joining 52 Neighboring gene T cell receptor alpha joining 49 Neighboring gene T cell receptor alpha joining 50 Neighboring gene T cell receptor alpha joining 51 (pseudogene) Neighboring gene T cell receptor delta constant Neighboring gene T cell receptor alpha joining 48 Neighboring gene T cell receptor alpha joining 47 Neighboring gene T cell receptor alpha joining 46 Neighboring gene T cell receptor alpha joining 45 Neighboring gene T cell receptor alpha joining 44 Neighboring gene T cell receptor alpha joining 41 Neighboring gene T cell receptor alpha joining 42 Neighboring gene T cell receptor alpha joining 43 Neighboring gene T cell receptor alpha joining 40 Neighboring gene T cell receptor alpha joining 39 Neighboring gene T cell receptor alpha joining 38 Neighboring gene T cell receptor alpha joining 37 Neighboring gene T cell receptor alpha joining 36 Neighboring gene T cell receptor alpha joining 32 Neighboring gene T cell receptor alpha joining 33 Neighboring gene T cell receptor alpha joining 34 Neighboring gene T cell receptor alpha joining 35 (non-functional) Neighboring gene T cell receptor alpha joining 31 Neighboring gene T cell receptor alpha joining 30 Neighboring gene T cell receptor alpha joining 29 Neighboring gene T cell receptor alpha joining 28 Neighboring gene T cell receptor alpha joining 27 Neighboring gene T cell receptor alpha joining 23 Neighboring gene T cell receptor alpha joining 24 Neighboring gene T cell receptor alpha joining 25 (non-functional) Neighboring gene T cell receptor alpha joining 26 Neighboring gene T cell receptor alpha joining 22 Neighboring gene T cell receptor alpha joining 21 Neighboring gene T cell receptor alpha joining 20 Neighboring gene T cell receptor alpha joining 19 (non-functional) Neighboring gene T cell receptor alpha joining 18 Neighboring gene T cell receptor alpha joining 17 Neighboring gene T cell receptor alpha joining 16 Neighboring gene T cell receptor alpha joining 12 Neighboring gene T cell receptor alpha joining 13 Neighboring gene T cell receptor alpha joining 14 Neighboring gene T cell receptor alpha joining 15 Neighboring gene T cell receptor alpha joining 11 Neighboring gene T cell receptor alpha joining 10 Neighboring gene T cell receptor alpha joining 9 Neighboring gene T cell receptor alpha joining 8 Neighboring gene T cell receptor alpha joining 7 Neighboring gene T cell receptor alpha joining 6 Neighboring gene T cell receptor alpha joining 5 Neighboring gene T cell receptor alpha joining 4 Neighboring gene T cell receptor alpha joining 3 Neighboring gene T cell receptor alpha joining 2 (non-functional) Neighboring gene T cell receptor alpha joining 1 (non-functional) Neighboring gene T cell receptor alpha constant Neighboring gene defender against cell death 1 Neighboring gene abhydrolase domain containing 4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Correlation between TCRCalpha -560 C/T polymorphism and the clinical presentation of Uygur IgA nephropathy patients in XinJiang. Lu C, et al. Asian Pac J Allergy Immunol, 2011 Sep. PMID 22053593.
    2. Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression. Markegard E, et al. PLoS One, 2011. PMID 21966541.
    3. A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease. Killebrew JR, et al. J Immunol, 2011 Jul 15. PMID 21690323.
    4. Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety. Ochi T, et al. Blood, 2011 Aug 11. PMID 21673345.
    5. Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells. Schrum AG, et al. J Immunol, 2011 Jul 15. PMID 21666056.

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. TCRCalpha-560 C/T gene polymerphism may be associated with the occurrence of intermittent microscopic hematuria and proteinuria in Chinese Uygur IgA nephropathy patients
      Title: Correlation between TCRCalpha -560 C/T polymorphism and the clinical presentation of Uygur IgA nephropathy patients in XinJiang.
    2. Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRalpha gene expression.
      Title: Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRα gene expression.
    3. Results suggest that gene-immunotherapy for leukemia using this WT1-siTCR system holds considerable promise.
      Title: Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety.
    4. Scurfy mouse TCRalpha gene recognizes a cutaneous autoantigen TCR that drives development of both conventional CD4-positive Foxp3-negative T cells as well as Foxp3-positive regulatory T (Treg) cells.
      Title: A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease.
    5. The potential for bivalent expression of the CD3/TCRalphabeta complex may represent a general feature of antigen receptors that mediate adaptive immunity.
      Title: Physical and functional bivalency observed among TCR/CD3 complexes isolated from primary T cells.
    6. study demonstrates that exogenous TCR alpha and beta chains transferred into the human immature RAG(+) T cell line Sup-T1 by lentiviral transduction inhibit RAG expression through tonic signaling
      Title: TCR transfer induces TCR-mediated tonic inhibition of RAG genes in human T cells.
    7. the T cell receptor alphabeta (TCR-alphabeta) was significantly induced subsequent to stimulation with head and neck squamous cell carcinoma in-vitro (p = 0.009) and also present in metastatic lymph nodes in-vivo
      Title: Expression of the T cell receptor αβ on a CD123+ BDCA2+ HLA-DR+ subpopulation in head and neck squamous cell carcinoma.
    8. The cell polarity protein PALS1 is expressed in T lymphocytes and participates to the optimal activation of NF-kappaB following TCR stimulation.
      Title: Participation of the cell polarity protein PALS1 to T-cell receptor-mediated NF-κB activation.
    9. Low peptide-histocompatibility complex (MHC) stability permits survival of T cells expressing self-reactive low peptide-MHC stability can permit the survival of T cells expressing self-reactive T cell receptors that bind in a traditional mode.
      Title: Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics.
    10. The adaptor LAT contains several conserved serine-based motifs, which are essential for proper signal transduction through the TCR.
      Title: Serine residues in the LAT adaptor are essential for TCR-dependent signal transduction.
    Submit: New GeneRIF Correction See all (47)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.

    Leukemia/lymphoma, T-cell

    Narcolepsy is strongly associated with the T-cell receptor alpha locus.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:112815 BioGRID:109350 HLA-A    BioGRID  PubMed Co-crystal Structure 
    BioGRID:112815 BioGRID:109368 HLA-DRB1    BioGRID  PubMed Co-crystal Structure 
    BioGRID:112815 BioGRID:111465 MED1    BioGRID  PubMed Co-purification 
    BioGRID:112815 BioGRID:115293 MED12    BioGRID  PubMed Co-purification 
    BioGRID:112815 BioGRID:114699 MED14    BioGRID  PubMed Co-purification 
    BioGRID:112815 BioGRID:115342 MED16    BioGRID  PubMed Co-purification 
    BioGRID:112815 BioGRID:114830 MED17    BioGRID  PubMed Co-purification 
    BioGRID:112815 BioGRID:115196 MED24    BioGRID  PubMed Co-purification 
    BioGRID:112815 BioGRID:116691 NCOA6    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:112815 BioGRID:111461 PPARA    BioGRID  PubMed Co-localization 
    BioGRID:112815 BioGRID:112300 SEL1L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112815 BioGRID:124085 SYVN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112815 BioGRID:115292 THRAP3    BioGRID  PubMed Co-purification 
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    General gene information

    Markers

    Pathways from BioSystems

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    General protein information

    Names
    T cell receptor alpha locus
    T-cell receptor, alpha (V,D,J,C)
    T-cell antigen receptor, alpha polypeptide
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_001332.2 Reference

      Range
      145152..1076166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000014.8 Reference GRCh37.p5 Primary Assembly

      Range
      22090057..23021075
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000146.1 Alternate HuRef

      Range
      2207926..3139292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE000521.1 AAB68997.1
      AAB68998.1
      AAB69000.1
      AAB69001.1
    genomic AE000659.1 (1..251141) None
    genomic AE000662.1 (1..58220) None
    genomic M94081.1 (43970..69969) None
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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