VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) [Homo sapiens] - Gene

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Summary

Official Symbol: VPS72provided by HGNC
Official Full Name: vacuolar protein sorting 72 homolog (S. cerevisiae)provided by HGNC
Primary source: HGNC:11644
Locus tag: RP11-68I18.8
See related: Ensembl:ENSG00000163159; HPRD:02791; MIM:600607; Vega:OTTHUMG00000012345
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: YL1; CFL1; Swc2; YL-1; TCFL1

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Genomic context

Location :: 1q21

Sequence :: Chromosome: 1; NC_000001.10 (151148934..151162640, complement)

See VPS72 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results identify YL1 as a subunit of the TRRAP/TIP60 HAT complex, and also as a component of a novel mammalian multiprotein complex that includes the SNF2-related helicase SRCAP.
Title: The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q15906	NDP52	CALCOCO2	HPRD	PubMed
Q15906	Q15834	CCDC85B	HPRD	PubMed
Q15906	Q01844	EWSR1	HPRD	PubMed
Q15906	Q99750	MDFI	HPRD	PubMed
BioGRID:112804	BioGRID:120548	C20orf20	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112804	BioGRID:115535	CALCOCO2	BioGRID	PubMed	Two-hybrid
BioGRID:112804	BioGRID:116198	CCDC85B	BioGRID	PubMed	Two-hybrid
BioGRID:112804	BioGRID:121004	DMAP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112804	BioGRID:108431	EWSR1	BioGRID	PubMed	Two-hybrid
BioGRID:112804	BioGRID:115779	KAT5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112804	BioGRID:110353	MDFI	BioGRID	PubMed	Two-hybrid
BioGRID:112804	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
chromatin modification	IEA Inferred from Electronic Annotation more info
negative regulation of transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
somatic stem cell maintenance	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info
protein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: vacuolar protein sorting-associated protein 72 homolog

Names: vacuolar protein sorting-associated protein 72 homolog; protein YL-1; transcription factor-like 1 (YL-1)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005997.1 → NP_005988.1 vacuolar protein sorting-associated protein 72 homolog

Status: PROVISIONAL

Source sequence(s)

D43642

Consensus CDS

CCDS989.1

UniProtKB/Swiss-Prot

Q15906

Related

ENSP00000357887, OTTHUMP00000014278, ENST00000368892, OTTHUMT00000034393

Conserved Domains (2) summary

cl02154
Location:291 – 319
Blast Score: 125

YL1_C; YL1 nuclear protein C-terminal domain

pfam05764
Location:4 – 218
Blast Score: 485

YL1; YL1 nuclear protein

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

151148934..151162640, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

122527060..122540781, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL592424.13	CAI16385.1
		CAO72042.1
genomic	CH471121.2	EAW53462.1
mRNA	AK222935.1	BAD96655.1
mRNA	AK222939.1	BAD96659.1
mRNA	AK225130.1	None
mRNA	AK297565.1	BAG59957.1
mRNA	AK310045.1	None
mRNA	BC003151.1	AAH03151.1
mRNA	BT019356.1	AAV38163.1
mRNA	BT019357.1	AAV38164.1
mRNA	D43642.1	BAA07757.1
mRNA	DQ655941.2	None
mRNA	DQ656047.2	None
other-genetic	DQ892940.2	ABM83866.1
other-genetic	DQ896189.2	ABM87188.1