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TCF3 transcription factor 3 [ Homo sapiens (human) ]

Gene ID: 6929, updated on 18-May-2013

Summary

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Official Symbol: TCF3provided by HGNC
Official Full Name: transcription factor 3provided by HGNC
Primary source: HGNC:11633
See related: Ensembl:ENSG00000071564; HPRD:00918; MIM:147141; Vega:OTTHUMG00000180031
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: E2A; E47; ITF1; VDIR; TCF-3; bHLHb21
Summary: This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011]

Genomic context

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Location :: 19p13.3

Sequence :: Chromosome: 19; NC_000019.9 (1609289..1652328, complement)

See TCF3 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

We present the first evidence that the portion of E2A proteins found within the oncogenic fusion protein E2A-PBX1 and including the transcriptional activation domains can enhance the HAT activity of CBP/p300
Title: E2A proteins enhance the histone acetyltransferase activity of the transcriptional co-activators CBP and p300.
our findings show that the E2A proteins are acetylated at specific residues as a consequence of lysine acetyltranferases(CBP, p300 and PCAF ) recruitment
Title: Mapping acetylation sites in E2A identifies a conserved lysine residue in activation domain 1 that promotes CBP/p300 recruitment and transcriptional activation.
Tcf3is partially responsible for the butyrate-resistant phenotype of colorectal cancer cells, as this DNA-binding protein suppresses the hyperinduction of Wnt activity by butyrate.
Title: Tcf3 and cell cycle factors contribute to butyrate resistance in colorectal cancer cells.
The molecular mechanism for this effect of EB1089 on the aromatase gene expression was found to be mediated by the vitamin D receptor (VDR), vitamin D receptor interacting repressor (VDIR) and Williams syndrome transcription factor (WSTF).
Title: Vitamin D analog EB1089 inhibits aromatase expression by dissociation of comodulator WSTF from the CYP19A1 promoter-a new regulatory pathway for aromatase.
E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to graft-versus-leukemia effect by upregulating death receptors for TRAIL.
Title: Oncogenic fusion E2A-HLF sensitizes t(17;19)-positive acute lymphoblastic leukemia to TRAIL-mediated apoptosis by upregulating the expression of death receptors.
Our results identify TCF3 as a central regulator of tumor growth and initiation.
Title: Control of breast cancer growth and initiation by the stem cell-associated transcription factor TCF3.
Absence of T cell precursor potential, both in vivo and in vitro, is due to low Notch1 expression and secondary to inhibition of E2A protein activity by members of the inhibitor of DNA binding (Id) protein family.
Title: Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors.
Protein inhibitor of activated STAT, PIASy regulates alpha-smooth muscle actin expression by interacting with E12 in mesangial cells.
Title: Protein inhibitor of activated STAT, PIASy regulates α-smooth muscle actin expression by interacting with E12 in mesangial cells.
These results thus implicate the E2A-CDKN1A transcriptional axis in the control of megakaryopoiesis and reveal the lineage-selective inhibition of this axis as a likely mechanistic basis for the inhibitory effects of cAMP signaling.
Title: Cyclic AMP signaling inhibits megakaryocytic differentiation by targeting transcription factor 3 (E2A) cyclin-dependent kinase inhibitor 1A (CDKN1A) transcriptional axis.
These results for the first time demonstrate that E2A could in fact acts as a tumor promoter at least in prostate cancer.
Title: Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis.

Submit: New GeneRIF Correction See all (60)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Tat, p14	tat	Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_003191.1	NP_004340.1	RUNX1T1	BIND	PubMed	ETO interacts with E2A.
P15923	AE binding protein 1	AEBP1	HPRD	PubMed
P15923	Q9NQ33	ASCL3	HPRD	PubMed
P15923	Q7RTS1	BHLHA15	HPRD	PubMed
P15923	Calmodulin 1	CALM1	HPRD	PubMed
P15923	Calmodulin 3	CALM3	HPRD	PubMed
P15923	Q92793	CREBBP	HPRD	PubMed
P15923	P35222	CTNNB1	HPRD	PubMed
P15923	P41970	ELK3	HPRD	PubMed
P15923	Q09472	EP300	HPRD	PubMed
P15923	Fer3 like	FERD3L	HPRD	PubMed
P15923	O96004	HAND1	HPRD	PubMed
P15923	P61296	HAND2	HPRD	PubMed
P15923	P49639	HOXA1	HPRD	PubMed
P15923	P41134	ID1	HPRD	PubMed
P15923	Q02363	ID2	HPRD	PubMed
P15923	Q02535	ID3	HPRD	PubMed
P15923	Q92831	KAT2B	HPRD	PubMed
P15923	O60663	LMX1B	HPRD	PubMed
P15923	P12980	LYL1	HPRD	PubMed
P15923	P28482	MAPK1	HPRD	PubMed
P15923	P27361	MAPK3	HPRD	PubMed
P15923	P49137	MAPKAPK2	HPRD	PubMed
P15923	Q16644	MAPKAPK3	HPRD	PubMed
P15923	Q99750	MDFI	HPRD	PubMed
P15923	O60682	MSC	HPRD	PubMed
P15923	P13349	MYF5	HPRD	PubMed
P15923	P15172	MYOD1	HPRD	PubMed
P15923	P15173	MYOG	HPRD	PubMed
P15923	Q14511	NEDD9	HPRD	PubMed
P15923	P52945	PDX1	HPRD	PubMed
P15923	P55036	PSMD4	HPRD	PubMed
P15923	O00233	PSMD9	HPRD	PubMed
P15923	Q6GYQ0	RALGAPA1	HPRD	PubMed
P15923	Q06455	RUNX1T1	HPRD	PubMed
P15923	Q13309	SKP2	HPRD	PubMed
P15923	P11831	SRF	HPRD	PubMed
P15923	P17542	TAL1	HPRD	PubMed
P15923	Q16559	TAL2	HPRD	PubMed
P15923	Q99081	TCF12	HPRD	PubMed
P15923	O43680	TCF21	HPRD	PubMed
P15923	P15923	TCF3	HPRD	PubMed
P15923	P0C1Z6	TFPT	HPRD	PubMed
P15923	Q15672	TWIST1	HPRD	PubMed
P15923	P63279	UBE2I	HPRD	PubMed
BioGRID:112791	BioGRID:111790	ALDH18A1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:119674	ASB2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112791	BioGRID:124350	ATOH8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:106979	ATP2A3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:114497	BAZ1B	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:112791	BioGRID:127970	BHLHA15	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:119650	C14orf166	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:107169	C1QBP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:107252	CALM1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:107271	CANX	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:117116	CASP14	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:107311	CBFA2T3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112791	BioGRID:115827	CCT2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:120267	CHCHD3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:107740	COX7A2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:107754	CPD	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:107777	CREBBP	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-fractionation; Phenotypic Enhancement
BioGRID:112791	BioGRID:107857	CSTA	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide
BioGRID:112791	BioGRID:107985	DAXX	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:115776	DDX17	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:116387	DDX20	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:119947	DNAJC10	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:108123	DNMT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112791	BioGRID:108238	EEF1A2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:108299	EIF5A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:108309	ELAVL1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-RNA
BioGRID:112791	BioGRID:108319	ELK3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112791	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-fractionation; Co-localization; Phenotypic Enhancement; Two-hybrid
BioGRID:112791	BioGRID:117666	ERAL1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:116331	ERLIN2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:108399	FBL	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:132815	FLG2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:114442	FOXH1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112791	BioGRID:108797	FUS	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112791	BioGRID:116808	GSE1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:114850	HAND2	BioGRID	PubMed	Two-hybrid
BioGRID:112791	BioGRID:109316	HDAC2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112791	BioGRID:115530	HNRNPR	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:109623	ID1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:112791	BioGRID:109624	ID2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Two-hybrid
BioGRID:112791	BioGRID:109625	ID3	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex; Two-hybrid
BioGRID:112791	BioGRID:109626	ID4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:116185	IMMT	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:129701	INO80E	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:108918	KAT2A	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:114375	KAT2B	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-fractionation; Phenotypic Enhancement
BioGRID:112791	BioGRID:116667	KDM1A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:120998	LANCL2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:110122	LBR	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:114384	LDB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112791	BioGRID:110154	LGALS7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:110194	LMX1A	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:112791	BioGRID:110244	LYL1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:112791	BioGRID:113617	MAPKAPK3	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Two-hybrid
BioGRID:112791	BioGRID:110319	MAX	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:110384	MEN1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112791	BioGRID:112070	MRPL23	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:119410	MRPL37	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:119918	MRPL39	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:122389	MRPL44	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:107199	MRPL49	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:110702	MYF5	BioGRID	PubMed	Two-hybrid
BioGRID:112791	BioGRID:110703	MYF6	BioGRID	PubMed	Two-hybrid
BioGRID:112791	BioGRID:126617	MYL6B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:110567	MYO1B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:110737	MYOD1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:112791	BioGRID:110739	MYOG	BioGRID	PubMed	Two-hybrid
BioGRID:112791	BioGRID:201673	Myod1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:114973	NCOR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112791	BioGRID:110790	NDUFB4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:110872	NHLH1	BioGRID	PubMed	Two-hybrid
BioGRID:112791	BioGRID:110873	NHLH2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:201706	Ncl	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:111126	PCBP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:111321	PIP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:111441	PON2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:111553	PRKACA	BioGRID	PubMed	Biochemical Activity
BioGRID:112791	BioGRID:115688	PRMT5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:115842	PRPF8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:111860	RB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112791	BioGRID:114952	RBM39	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:116796	RCOR1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:112057	RPL13	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:114507	RPL14	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:112067	RPL23A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:112071	RPL24	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:112079	RPL31	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:112092	RPL36A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:112086	RPL37	BioGRID	PubMed	Two-hybrid
BioGRID:112791	BioGRID:112100	RPN2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:112121	RPS13	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:123193	RUFY1	BioGRID	PubMed	Two-hybrid
BioGRID:112791	BioGRID:107309	RUNX1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112791	BioGRID:107310	RUNX1T1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112791	BioGRID:212778	Rpa1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:229774	Rufy1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:112201	SAFB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:130613	SCXA	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:112791	BioGRID:107318	SERPINH1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:571638	SETP18	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:116146	SF3A3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:117439	SIN3A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112791	BioGRID:112393	SKP2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112791	BioGRID:107850	SLC25A10	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:106788	SLC25A4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:114769	SLC9A3R1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:112481	SMARCA4	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:112791	BioGRID:112534	SON	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:112540	SOX2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:116130	SPIN1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:112620	SSBP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:116457	STK38	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:114042	SUPT3H	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:203115	Scx	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:112734	TADA2A	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:112749	TAL1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:112791	BioGRID:112798	TCF12	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112791	BioGRID:934215	TCF24	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:112791	TCF3	BioGRID	PubMed	Affinity Capture-MS; Co-fractionation; Reconstituted Complex
BioGRID:112791	BioGRID:112787	TCF4	BioGRID	PubMed	Two-hybrid
BioGRID:112791	BioGRID:120151	TET2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:112891	TFF3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:124961	TIMM50	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:112943	TLE1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:119625	TRIM33	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:113900	TRRAP	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:113142	TWIST1	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex; Two-hybrid
BioGRID:112791	BioGRID:203991	Tbx6	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:204000	Tcf12	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:219911	Tfap4	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:199209	Twist2	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:112791	BioGRID:113177	UBE2I	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:112791	BioGRID:113231	UQCRC2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112791	BioGRID:113237	USF1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:112791	BioGRID:247604	Ube2i	BioGRID	PubMed	Two-hybrid
BioGRID:112791	BioGRID:204464	Usf1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112791	BioGRID:113264	VDR	BioGRID	PubMed	Affinity Capture-Western; Co-localization; Reconstituted Complex
BioGRID:112791	BioGRID:113360	YY1	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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CDO in myogenesis, organism-specific biosystem (from REACTOME)
CDO in myogenesis, organism-specific biosystemCDO/Cdon (cell-adhesion-molecule-related/downregulated by oncogenes) is a type I transmembrane multifunctional co-receptor consisting of five immunoglobulin and three fibronectin type III (FNIII) rep...
Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
Myogenesis, organism-specific biosystem (from REACTOME)
Myogenesis, organism-specific biosystemMyogenesis, the formation of muscle tissue, is a complex process involving steps of cell proliferation mediated by growth factor signaling, cell differentiation, reorganization of cells to form myotu...
Notch-mediated HES/HEY network, organism-specific biosystem (from Pathway Interaction Database)
Notch-mediated HES/HEY network, organism-specific biosystem
Notch-mediated HES/HEY network
Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
Regulation of nuclear SMAD2/3 signaling, organism-specific biosystem
Regulation of nuclear SMAD2/3 signaling
SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer
Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
p38 signaling mediated by MAPKAP kinases, organism-specific biosystem (from Pathway Interaction Database)
p38 signaling mediated by MAPKAP kinases, organism-specific biosystem
p38 signaling mediated by MAPKAP kinases

General gene information

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Markers

G29322 (e-PCR)
- UniSTS:69389

RH12886 (e-PCR)
- UniSTS:63271

TCF3_4169 (e-PCR)
- UniSTS:462934

G15946 (e-PCR)
- UniSTS:33389

STS-M65214 (e-PCR)
- UniSTS:74964

WI-18183 (e-PCR)
- UniSTS:61171

Homology

Homologs of the TCF3 gene: The TCF3 gene is conserved in dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to DNA binding	IDA Inferred from Direct Assay more info	PubMed
DNA binding	NAS Non-traceable Author Statement more info	PubMed
E-box binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to E-box binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to E-box binding	ISS Inferred from Sequence or Structural Similarity more info
bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
chromatin binding	IEA Inferred from Electronic Annotation more info
mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	NAS Non-traceable Author Statement more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
repressing transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
sequence-specific DNA binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed
vitamin D response element binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
B cell differentiation	NAS Non-traceable Author Statement more info	PubMed
B cell lineage commitment	IDA Inferred from Direct Assay more info	PubMed
B cell lineage commitment	NAS Non-traceable Author Statement more info	PubMed
G1 phase of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
Peyer's patch development	IEA Inferred from Electronic Annotation more info
T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
cell development	IEA Inferred from Electronic Annotation more info
histone H3 acetylation	IEA Inferred from Electronic Annotation more info
histone H4 acetylation	IEA Inferred from Electronic Annotation more info
immunoglobulin V(D)J recombination	IDA Inferred from Direct Assay more info	PubMed
muscle cell differentiation	TAS Traceable Author Statement more info
natural killer cell differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
positive regulation of muscle cell differentiation	TAS Traceable Author Statement more info
positive regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-dependent	ISS Inferred from Sequence or Structural Similarity more info
protein stabilization	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed
response to drug	IEA Inferred from Electronic Annotation more info
response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
nuclear nucleosome	IEA Inferred from Electronic Annotation more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	NAS Non-traceable Author Statement more info	PubMed
protein complex	IDA Inferred from Direct Assay more info	PubMed
transcription factor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor E2-alpha

Names: transcription factor E2-alpha; kappa-E2-binding factor; VDR interacting repressor; transcription factor ITF-1; helix-loop-helix protein HE47; immunoglobulin transcription factor 1; vitamin D receptor-interacting repressor; class B basic helix-loop-helix protein 21; negative vitamin D response element-binding protein; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029953.1 RefSeqGene

Range

5001..48040

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001136139.2 → NP_001129611.1 transcription factor E2-alpha isoform E47

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' UTR, lacks an exon and includes an alternate exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (E47, also known as Pan-1) is shorter than isoform E12.

Source sequence(s)

AC005321, AW028755, BG284440, BU528547, CD516687, CD674814, M24404

Consensus CDS

CCDS45899.1

UniProtKB/Swiss-Prot

P15923

Related

ENSP00000344375, ENST00000344749
NM_003200.3 → NP_003191.1 transcription factor E2-alpha isoform E12

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (E12). This isoform is also known as Pan-2.

Source sequence(s)

AC005321, M31222

Consensus CDS

CCDS12074.1

UniProtKB/Swiss-Prot

P15923

Related

ENSP00000262965, OTTHUMP00000263159, ENST00000262965, OTTHUMT00000449367

Conserved Domains (1) summary

cd00083
Location:547 – 607
Blast Score: 136

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p10 Primary Assembly

Range

1609289..1652328, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

1383232..1423075, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018930.1 Alternate CHM1_1.0

Range

1537914..1578916, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01002664.1 (16360..19084)	None
genomic	ABBA01002665.1	None
genomic	AC005321.1	AAC27373.1
genomic	AC006274.1	AAC99797.1
genomic	AMYH01009256.1 (3773..22544)	None
genomic	AMYH01009257.1	None
genomic	CH471139.2	EAW69467.1
		EAW69468.1
		EAW69469.1
		EAW69470.1
		EAW69471.1
		EAW69472.1
genomic	HI179080.1	CBX53848.1
mRNA	AK024806.1	None
mRNA	AK310998.1	None
mRNA	AW028755.1	None
mRNA	BC005166.2	None
mRNA	BC011665.2	AAH11665.1
mRNA	BC014680.1	None
mRNA	BC110580.1	AAI10581.1
mRNA	BG284440.1	None
mRNA	BU528547.1	None
mRNA	CD516687.1	None
mRNA	CD674814.1	None
mRNA	M24404.1	AAA56829.1
mRNA	M24405.1	AAA56830.1
mRNA	M31222.1	AAA52331.1
mRNA	M31523.1	AAA61146.1
mRNA	M65214.1	AAC41693.1
mRNA	X52078.1	CAA36297.1