Adh6a alcohol dehydrogenase 6A (class V) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adh6aprovided by MGI
Official Full Name: alcohol dehydrogenase 6A (class V)provided by MGI
Primary source: MGI:MGI:1916367
See related: Ensembl:ENSMUSG00000053054 AllianceGenome:MGI:1916367
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adh5a; 1810009C16Rik
Summary: Predicted to enable NAD-retinol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; and zinc ion binding activity. Predicted to be involved in ethanol oxidation; retinoic acid metabolic process; and retinol metabolic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 44.5), small intestine adult (RPKM 35.6) and 1 other tissue See more
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Genomic context

Location:: 3 G3; 3 64.19 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (138019047..138036895)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (138313286..138331134)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adh6a gene expression patterns.
Title: Tissue expression pattern of class II and class V genes found in the Adh complex on mouse chromosome 3.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alcohol dehydrogenase (NAD+) activity, zinc-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in retinoic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinol metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alcohol dehydrogenase 6A (class V)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026945.1 → NP_081221.1 alcohol dehydrogenase 6A (class V)

Status: VALIDATED

Source sequence(s)

AK007397, AK028114, BB870350

Consensus CDS

CCDS38652.1

UniProtKB/TrEMBL

A1L3C0, E9Q5Z6

Related

ENSMUSP00000101854.2, ENSMUST00000106247.2

Conserved Domains (2) summary

COG1062
Location:8 → 375

FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

cl16912
Location:3 → 375

MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family