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    Chac1 ChaC, cation transport regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 69065, updated on 26-Feb-2013
    Official Symbol
    Chac1provided by MGI
    Official Full Name
    ChaC, cation transport regulator 1provided by MGI
    Primary source
    MGI:1916315
    Locus tag
    RP23-46P4.9
    See related
    Ensembl:ENSMUSG00000027313; Vega:OTTMUSG00000015948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810008K03Rik
    Location :
    2 E5; 2
    Sequence :
    Chromosome: 2; NC_000068.7 (119351242..119354326)
    See Chac1 in Epigenomics, MapViewer

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19294 Neighboring gene vacuolar protein sorting 18 (yeast) Neighboring gene predicted gene 14207 Neighboring gene delta-like 4 (Drosophila) Neighboring gene INO80 homolog (S. cerevisiae) Neighboring gene cyclin-dependent kinase 12 pseudogene

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Botch promotes neurogenesis by antagonizing Notch. Chi Z, et al. Dev Cell, 2012 Apr 17. PMID 22445366.
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    3. Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse. Wilson DG, et al. J Cell Biol, 2011 May 30. PMID 21606205.
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    5. SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder. Cantagrel V, et al. Cell, 2010 Jul 23. PMID 20637498.

    See all (17) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Notch binding IDA
    Inferred from Direct Assay
    more info
    		  
    Process Evidence Code Pubs
    Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		  
    response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		  
    Preferred Names
    cation transport regulator-like protein 1
    Names
    cation transport regulator-like protein 1
    botch
    blocks Notch protein
    ChaC, cation transport regulator-like 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026929.4 → NP_081205.1  cation transport regulator-like protein 1

      Status: VALIDATED

      Source sequence(s)
      AK007378, BI872476, BM899230
      Consensus CDS
      CCDS16601.1
      UniProtKB/Swiss-Prot
      Q8R3J5
      Related
      ENSMUSP00000028780, OTTMUSP00000017015, ENSMUST00000028780, OTTMUST00000037907
      Conserved Domains (1) summary
      cd06661
      Location:36 – 146
      Blast Score: 171
      GGCT_like; GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p1 C57BL/6J

      Range
      119351242..119354326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000024.1 Alternate Mm_Celera

      Range
      120503185..120506253
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01019985.1 (5722..8790) None
    genomic AL929318.11 (139057..142141) None
    genomic CH466519.1 EDL27950.1 mixed
    mRNA AK007378.1 BAB24997.1 C57BL/6J
    mRNA AK032218.1 BAC27764.1 C57BL/6J
    mRNA BC025169.1 AAH25169.1 FVB/N
    mRNA BI872476.1 None
    mRNA BM899230.1 None C57BL/6
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3J5.2 GenPept UniProtKB/Swiss-Prot:Q8R3J5

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).

      Links to other resources

      General information

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