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Haghl hydroxyacylglutathione hydrolase-like [ Mus musculus (house mouse) ]

Gene ID: 68977, updated on 8-May-2016
Official Symbol
Haghlprovided by MGI
Official Full Name
hydroxyacylglutathione hydrolase-likeprovided by MGI
Primary source
MGI:MGI:1919877
See related
Ensembl:ENSMUSG00000061046 Vega:OTTMUSG00000033886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500017E18Rik; 2810014I23Rik; C330022E15Rik
Orthologs
Location:
17; 17 A3.3
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (25779843..25785669, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (25919770..25922278, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene mesothelin Neighboring gene predicted gene, 41550 Neighboring gene nuclear prelamin A recognition factor-like Neighboring gene microRNA 6966 Neighboring gene coiled-coil domain containing 78 Neighboring gene family with sequence similarity 173, member A Neighboring gene meteorin, glial cell differentiation regulator

Markers

Homology

Clone Names

  • MGC101974

Gene Ontology Provided by MGI

Function Evidence Code Pubs
2,4,4-trimethyl-3-oxopentanoyl-CoA thioesterase activity IEA
Inferred from Electronic Annotation
more info
 
2-oxoglutaryl-CoA thioesterase activity IEA
Inferred from Electronic Annotation
more info
 
3-isopropylbut-3-enoyl-CoA thioesterase activity IEA
Inferred from Electronic Annotation
more info
 
CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
acyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
glutaryl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydroxyacylglutathione hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
Preferred Names
hydroxyacylglutathione hydrolase-like protein
NP_001258362.1
NP_001258363.1
NP_001258364.1
NP_001258365.1
NP_001258366.1
NP_081173.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271433.1NP_001258362.1  hydroxyacylglutathione hydrolase-like protein isoform a

    See identical proteins and their annotated locations for NP_001258362.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AI844861, BC083322, BY265614
    Consensus CDS
    CCDS28527.1
    UniProtKB/Swiss-Prot
    Q9DB32
    Related
    ENSMUSP00000077091, OTTMUSP00000046161, ENSMUST00000077938, OTTMUST00000085449
    Conserved Domains (2) summary
    COG0491
    Location:1226
    GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
    cl00446
    Location:1245
    Lactamase_B; Metallo-beta-lactamase superfamily
  2. NM_001271434.1NP_001258363.1  hydroxyacylglutathione hydrolase-like protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AI844861, AK012748, BY265614
    Conserved Domains (1) summary
    cl00446
    Location:1201
    Lactamase_B; Metallo-beta-lactamase superfamily
  3. NM_001271435.1NP_001258364.1  hydroxyacylglutathione hydrolase-like protein isoform c

    See identical proteins and their annotated locations for NP_001258364.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 3' UTR and 3' coding region compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK047517, BY265614
    Consensus CDS
    CCDS70773.1
    UniProtKB/Swiss-Prot
    Q9DB32
    Related
    ENSMUSP00000116841, OTTMUSP00000046164, ENSMUST00000140738, OTTMUST00000085453
    Conserved Domains (2) summary
    COG0491
    Location:1226
    GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
    cl00446
    Location:1231
    Lactamase_B; Metallo-beta-lactamase superfamily
  4. NM_001271436.1NP_001258365.1  hydroxyacylglutathione hydrolase-like protein isoform d

    See identical proteins and their annotated locations for NP_001258365.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 5 and 6 encode the same isoform (d).
    Source sequence(s)
    AI844861, AK012748, AK021220, BY265614
    Consensus CDS
    CCDS70772.1
    UniProtKB/TrEMBL
    D3YZU6
    Related
    ENSMUSP00000120885, OTTMUSP00000046162, ENSMUST00000133071, OTTMUST00000085450
    Conserved Domains (1) summary
    cl00446
    Location:1197
    Lactamase_B; Metallo-beta-lactamase superfamily
  5. NM_001271437.1NP_001258366.1  hydroxyacylglutathione hydrolase-like protein isoform d

    See identical proteins and their annotated locations for NP_001258366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks a portion of the 5' UTR and 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a. Variants 5 and 6 encode the same isoform (d).
    Source sequence(s)
    AI844861, AK012748, AK021220, BY265614
    Consensus CDS
    CCDS70772.1
    UniProtKB/TrEMBL
    D3YZU6
    Related
    ENSMUSP00000115538, OTTMUSP00000046163, ENSMUST00000138759, OTTMUST00000085451
    Conserved Domains (1) summary
    cl00446
    Location:1197
    Lactamase_B; Metallo-beta-lactamase superfamily
  6. NM_026897.3NP_081173.1  hydroxyacylglutathione hydrolase-like protein isoform a

    See identical proteins and their annotated locations for NP_081173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AI844861, AK005274, BY293803
    Consensus CDS
    CCDS28527.1
    UniProtKB/Swiss-Prot
    Q9DB32
    Related
    ENSMUSP00000119647, OTTMUSP00000046165, ENSMUST00000150324, OTTMUST00000085455
    Conserved Domains (2) summary
    COG0491
    Location:1226
    GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
    cl00446
    Location:1245
    Lactamase_B; Metallo-beta-lactamase superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    25779843..25785669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524868.2XP_006524931.1  

    Conserved Domains (2) summary
    COG0491
    Location:1253
    GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
    cl00446
    Location:1258
    Lactamase_B; Metallo-beta-lactamase superfamily
  2. XM_006524867.2XP_006524930.1  

    Conserved Domains (2) summary
    COG0491
    Location:1253
    GloB; Glyoxylase or a related metal-dependent hydrolase, beta-lactamase superfamily II [General function prediction only]
    cl00446
    Location:1272
    Lactamase_B; Metallo-beta-lactamase superfamily
  3. XM_006524870.2XP_006524933.1  

    See identical proteins and their annotated locations for XP_006524933.1

    Conserved Domains (1) summary
    cl00446
    Location:1224
    Lactamase_B; Metallo-beta-lactamase superfamily
  4. XM_006524869.2XP_006524932.1  

    See identical proteins and their annotated locations for XP_006524932.1

    Conserved Domains (1) summary
    cl00446
    Location:1224
    Lactamase_B; Metallo-beta-lactamase superfamily

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    26312649..26318392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)