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TARS threonyl-tRNA synthetase [ Homo sapiens (human) ]

Gene ID: 6897, updated on 26-May-2016
Official Symbol
TARSprovided by HGNC
Official Full Name
threonyl-tRNA synthetaseprovided by HGNC
Primary source
HGNC:HGNC:11572
See related
Ensembl:ENSG00000113407 HPRD:01762; MIM:187790; Vega:OTTHUMG00000090683
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ThrRS
Summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Threonyl-tRNA synthetase belongs to the class-II aminoacyl-tRNA synthetase family [provided by RefSeq, Jul 2008]
Orthologs
Location:
5p13.2
Exon count:
21
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 5 NC_000005.10 (33440696..33468091)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (33440802..33468196)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S8 pseudogene 8 Neighboring gene uncharacterized LOC105374716 Neighboring gene uncharacterized LOC105374717 Neighboring gene translocase of outer mitochondrial membrane 40 homolog (yeast) pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA is identified to have a physical interaction with threonyl-tRNA synthetase (TARS) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC9344

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity NAS
Non-traceable Author Statement
more info
PubMed 
threonine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
threonine-tRNA ligase activity NAS
Non-traceable Author Statement
more info
PubMed 
threonine-tRNA ligase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
tRNA aminoacylation for protein translation TAS
Traceable Author Statement
more info
 
threonyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
 
threonyl-tRNA aminoacylation NAS
Non-traceable Author Statement
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
threonine--tRNA ligase, cytoplasmic
Names
threonine tRNA ligase 1, cytoplasmic
threonyl-tRNA synthetase, cytoplasmic
NP_001245366.1
NP_001245367.1
NP_689508.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258437.1NP_001245366.1  threonine--tRNA ligase, cytoplasmic isoform 1

    See identical proteins and their annotated locations for NP_001245366.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC025441, AK292346, BG183397
    Consensus CDS
    CCDS3899.1
    UniProtKB/Swiss-Prot
    P26639
    Related
    ENSP00000424387, OTTHUMP00000221016, ENST00000502553, OTTHUMT00000366772
    Conserved Domains (5) summary
    cd01667
    Location:83144
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:44716
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:250297
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:321618
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:618709
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
  2. NM_001258438.1NP_001245367.1  threonine--tRNA ligase, cytoplasmic isoform 2

    See identical proteins and their annotated locations for NP_001245367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is longer compared to isoform 1.
    Source sequence(s)
    AC025441, AC034231, AK293620, BG183397
    Consensus CDS
    CCDS58943.1
    UniProtKB/Swiss-Prot
    P26639
    Related
    ENSP00000387710, OTTHUMP00000221018, ENST00000455217, OTTHUMT00000366774
    Conserved Domains (5) summary
    cd01667
    Location:83177
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:44749
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:283330
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:354651
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:651742
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
  3. NM_152295.4NP_689508.3  threonine--tRNA ligase, cytoplasmic isoform 1

    See identical proteins and their annotated locations for NP_689508.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the smaller protein (isoform 1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC025441, AW246273, BC000517
    Consensus CDS
    CCDS3899.1
    UniProtKB/Swiss-Prot
    P26639
    Related
    ENSP00000265112, OTTHUMP00000115851, ENST00000265112, OTTHUMT00000207367
    Conserved Domains (5) summary
    cd01667
    Location:83144
    TGS_ThrRS_N; TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and ...
    PLN02908
    Location:44716
    PLN02908; threonyl-tRNA synthetase
    smart00863
    Location:250297
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    cd00771
    Location:321618
    ThrRS_core; Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00860
    Location:618709
    ThrRS_anticodon; ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

RNA

  1. NR_047676.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC025441, AC034231, AK308342, BG183397
  2. NR_047677.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC025441, AC034231, AK296783, BG183397, KF510921
    Related
    ENST00000507716, OTTHUMT00000366775
  3. NR_047678.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC025441, AC034231, AK095852, BG183397
    Related
    ENST00000508361, OTTHUMT00000366773

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p2 Primary Assembly

    Range
    33440696..33468091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 Alternate CHM1_1.1

    Range
    33442410..33469806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)