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Vars2 valyl-tRNA synthetase 2, mitochondrial [ Mus musculus (house mouse) ]

Gene ID: 68915, updated on 13-Apr-2024

Summary

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Official Symbol
Vars2provided by MGI
Official Full Name
valyl-tRNA synthetase 2, mitochondrialprovided by MGI
Primary source
MGI:MGI:1916165
See related
Ensembl:ENSMUSG00000038838 AllianceGenome:MGI:1916165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vars2l; mKIAA1885; 1190004I24Rik
Summary
Predicted to enable valine-tRNA ligase activity. Predicted to be involved in valyl-tRNA aminoacylation. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and tail. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 20. Orthologous to human VARS2 (valyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 24.0), stomach adult (RPKM 15.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 18.7 cM
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35966526..35978531, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35655634..35667639, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene mucin like 3 Neighboring gene surfactant associated 2 Neighboring gene STARR-positive B cell enhancer ABC_E7529 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:35808865-35809171 Neighboring gene general transcription factor II H, polypeptide 4 Neighboring gene STARR-positive B cell enhancer ABC_E7530 Neighboring gene STARR-seq mESC enhancer starr_42470 Neighboring gene discoidin domain receptor family, member 1 Neighboring gene STARR-seq mESC enhancer starr_42472 Neighboring gene predicted gene, 23864

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables valine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables valine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in valyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
valine--tRNA ligase, mitochondrial
Names
valRS
valyl-tRNA synthetase 2, mitochondrial (putative)
valyl-tRNA synthetase, mitochondrial
NP_780346.3
XP_011244891.1
XP_030105896.1
XP_036016669.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429114.1 → NP_001416043.1  valine--tRNA ligase, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CR974483

  2. NM_001429115.1 → NP_001416044.1  valine--tRNA ligase, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    CR974483

  3. NM_175137.5 → NP_780346.3  valine--tRNA ligase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_780346.3

    Status: VALIDATED

    Source sequence(s)
    CR974483
    Consensus CDS
    CCDS37602.1
    UniProtKB/Swiss-Prot
    E9QMJ4, Q3U2A8, Q69Z78, Q6PGG3, Q6ZQL7, Q8BIN9
    Related
    ENSMUSP00000047917.9, ENSMUST00000043674.15
    Conserved Domains (3) summary
    cd07962
    Location:735 → 869
    Anticodon_Ia_Val; Anticodon-binding domain of valyl tRNA synthetases
    cd00817
    Location:137 → 735
    ValRS_core; catalytic core domain of valyl-tRNA synthetases
    PTZ00419
    Location:90 → 1018
    PTZ00419; valyl-tRNA synthetase-like protein; Provisional

RNA

  1. NR_190578.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974483

  2. NR_190579.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974483

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35966526..35978531 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246589.3 → XP_011244891.1  valine--tRNA ligase, mitochondrial isoform X1

    Conserved Domains (1) summary
    PTZ00419
    Location:1 → 878
    PTZ00419; valyl-tRNA synthetase-like protein; Provisional

  2. XM_036160776.1 → XP_036016669.1  valine--tRNA ligase, mitochondrial isoform X2

    Related
    ENSMUST00000165787.8
    Conserved Domains (1) summary
    PTZ00419
    Location:34 → 799
    PTZ00419; valyl-tRNA synthetase-like protein; Provisional

  3. XM_030250036.1 → XP_030105896.1  valine--tRNA ligase, mitochondrial isoform X3

    Conserved Domains (1) summary
    PTZ00419
    Location:90 → 518
    PTZ00419; valyl-tRNA synthetase-like protein; Provisional

RNA

  1. XR_003952175.1 RNA Sequence

  2. XR_003952174.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U2A8.2 GenPept UniProtKB/Swiss-Prot:Q3U2A8

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