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TAL2 T-cell acute lymphocytic leukemia 2 [ Homo sapiens (human) ]

Gene ID: 6887, updated on 26-May-2016
Official Symbol
TAL2provided by HGNC
Official Full Name
T-cell acute lymphocytic leukemia 2provided by HGNC
Primary source
HGNC:HGNC:11557
See related
Ensembl:ENSG00000186051 HPRD:01735; MIM:186855; Vega:OTTHUMG00000020424
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009]
Orthologs
Location:
9q32
Exon count:
1
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (105662457..105663112)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (108418562..108425393)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376199 Neighboring gene fukutin Neighboring gene uncharacterized LOC105376200 Neighboring gene transmembrane protein 38B Neighboring gene serine/arginine-rich splicing factor 10 pseudogene Neighboring gene DEP domain containing 1 pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Acute lymphoid leukemia
MedGen: C0023449 OMIM: 613065 GeneReviews: Not available
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NHGRI GWAS Catalog

Description
Common genetic variation and performance on standardized cognitive tests.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
midbrain development IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
thalamus development IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
T-cell acute lymphocytic leukemia protein 2
Names
TAL-2
class A basic helix-loop-helix protein 19

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005421.2NP_005412.1  T-cell acute lymphocytic leukemia protein 2

    See identical proteins and their annotated locations for NP_005412.1

    Status: REVIEWED

    Source sequence(s)
    AA767775, BC126373
    Consensus CDS
    CCDS6767.1
    UniProtKB/Swiss-Prot
    Q16559
    Related
    ENSP00000334547, OTTHUMP00000021840, ENST00000334077, OTTHUMT00000053504
    Conserved Domains (1) summary
    cd00083
    Location:358
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    105662457..105663112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    108571782..108572437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)