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TAF12 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa [ Homo sapiens (human) ]

Gene ID: 6883, updated on 16-Apr-2014
Official Symbol
TAF12provided by HGNC
Official Full Name
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDaprovided by HGNC
Primary source
HGNC:11545
See related
Ensembl:ENSG00000120656; HPRD:15981; MIM:600773; Vega:OTTHUMG00000003655
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAF2J; TAFII20
Summary
Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]
Location :
1p35.3
Sequence :
Chromosome: 1; NC_000001.11 (28603096..28643101, complement)
See TAF12 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 16A Neighboring gene small nucleolar RNA host gene 12 (non-protein coding) Neighboring gene RAB42, member RAS oncogene family Neighboring gene RNA, U11 small nuclear Neighboring gene glucocorticoid modulatory element binding protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed
tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
PCAF complex IDA
Inferred from Direct Assay
more info
PubMed 
STAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
STAGA complex IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFTC complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
transcription initiation factor TFIID subunit 12
Names
transcription initiation factor TFIID subunit 12
TAFII20/TAFII15
TAFII-20/TAFII-15
transcription initiation factor TFIID 20/15 kDa subunits
TATA box binding protein (TBP)-associated factor, RNA polymerase II, J, 20kD

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135218.1NP_001128690.1  transcription initiation factor TFIID subunit 12

    See proteins identical to NP_001128690.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL360012, BC011986, BE787487, BM676557
    Consensus CDS
    CCDS326.1
    UniProtKB/Swiss-Prot
    Q16514
    Related
    ENSP00000263974, OTTHUMP00000003785, ENST00000263974, OTTHUMT00000010367
    Conserved Domains (1) summary
    cd07981
    Location:57128
    Blast Score: 322
    TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  2. NM_005644.3NP_005635.1  transcription initiation factor TFIID subunit 12

    See proteins identical to NP_005635.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BM676557, BX095156, U57693
    Consensus CDS
    CCDS326.1
    UniProtKB/Swiss-Prot
    Q16514
    Related
    ENSP00000362930, OTTHUMP00000003786, ENST00000373824, OTTHUMT00000010368
    Conserved Domains (1) summary
    cd07981
    Location:57128
    Blast Score: 322
    TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11

    Range
    28603096..28643101, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245978.1XP_005246035.1  

    See proteins identical to XP_005246035.1

    Conserved Domains (1) summary
    cd07981
    Location:109180
    Blast Score: 314
    TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  2. XM_006710860.1XP_006710923.1  

    Conserved Domains (1) summary
    cd07981
    Location:86157
    Blast Score: 316
    TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  3. XM_005245979.1XP_005246036.1  

    Conserved Domains (1) summary
    cd07981
    Location:99170
    Blast Score: 318
    TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  4. XM_006710861.1XP_006710924.1  

    See proteins identical to XP_006710924.1

    Conserved Domains (1) summary
    cd07981
    Location:57128
    Blast Score: 322
    TAF12; TATA Binding Protein (TBP) Associated Factor 12 (TAF12) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

Alternate HuRef

Genomic

  1. AC_000133.1 Alternate HuRef

    Range
    27182618..27222688, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    29045214..29085178, complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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