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TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa [ Homo sapiens (human) ]

Gene ID: 6882, updated on 24-Aug-2015
Official Symbol
TAF11provided by HGNC
Official Full Name
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDaprovided by HGNC
Primary source
HGNC:HGNC:11544
See related
Ensembl:ENSG00000064995; HPRD:15980; MIM:600772; Vega:OTTHUMG00000014556
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAF2I; PRO2134; TAFII28; MGC:15243
Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Orthologs
See TAF11 in Epigenomics, MapViewer
Location:
6p21.31
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (34877778..34888071, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (34845555..34855908, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide C Neighboring gene UHRF1 binding protein 1 Neighboring gene uncharacterized LOC105375030 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 1A Neighboring gene t-complex 11, testis-specific

NHGRI GWAS Catalog

Description
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed
tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein N-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
thyroid hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
vitamin D receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
transcription initiation factor TFIID subunit 11
Names
TAF(II)28
TAFII-28
TATA box binding protein (TBP)-associated factor, RNA polymerase II, I, 28kD
TFIID subunit p30-beta
transcription initiation factor TFIID 28 kD subunit
transcription initiation factor TFIID 28 kDa subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270488.1NP_001257417.1  transcription initiation factor TFIID subunit 11 isoform 2

    See identical proteins and their annotated locations for NP_001257417.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AI755269, AK302226, BC021972, DA153455
    Consensus CDS
    CCDS59014.1
    UniProtKB/Swiss-Prot
    Q15544
    Related
    ENSP00000408121, ENST00000420584
    Conserved Domains (1) summary
    cl02176
    Location:106136
    TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  2. NM_005643.3NP_005634.1  transcription initiation factor TFIID subunit 11 isoform 1

    See identical proteins and their annotated locations for NP_005634.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI755269, BC021972, DA153455
    Consensus CDS
    CCDS4797.1
    UniProtKB/Swiss-Prot
    Q15544
    Related
    ENSP00000354633, OTTHUMP00000016241, ENST00000361288, OTTHUMT00000040259
    Conserved Domains (1) summary
    cd08048
    Location:113195
    TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    34877778..34888071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514827.1XP_011513129.1  

    Conserved Domains (1) summary
    cd08048
    Location:69151
    TAF11; TATA Binding Protein (TBP) Associated Factor 11 (TAF11) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    34847609..34857911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)