KLF5 Kruppel-like factor 5 (intestinal) [Homo sapiens] - Gene

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Summary

Official Symbol: KLF5provided by HGNC
Official Full Name: Kruppel-like factor 5 (intestinal)provided by HGNC
Primary source: HGNC:6349
Locus tag: RP11-505F3.5
See related: Ensembl:ENSG00000102554; HPRD:04212; MIM:602903; Vega:OTTHUMG00000017074
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CKLF; IKLF; BTEB2
Summary: This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 13q22.1

Sequence :: Chromosome: 13; NC_000013.10 (73633142..73651676)

See KLF5 in Epigenomics, MapViewer

Chromosome 13 - NC_000013.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the expression of KLF5 and MMP-9 may be involved in cartilage degeneration, contributing to human osteoarthritis
Title: Clinicopathological correlation of Krüppel-like factor 5 and matrix metalloproteinase-9 expression and cartilage degeneration in human osteoarthritis.
TAZ promotes breast cell growth partially through protecting KLF5 from WWP1-mediated degradation and enhancing KLF5's activities.
Title: TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis.
The granulocyte-associated transcription factor Kruppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia.
Title: The granulocyte-associated transcription factor Krüppel-like factor 5 is silenced by hypermethylation in acute myeloid leukemia.
SMURF2 is a novel E3 ubiquitin ligase for KLF5 and negatively regulates KLF5 by targeting it for proteasomal degradation.
Title: The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein.
KLF5 transactivates NOTCH1 in the context of p53 mutation or loss. KLF5 loss limited NOTCH1 activity and was sufficient on its own to transform primary human keratinocytes harboring mutant p53, leading to the formation of invasive tumors.
Title: Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer.
KLF5 is a progesterone-induced gene that contributes to progesterone-mediated breast epithelial cell proliferation and dedifferentiation
Title: The induction of KLF5 transcription factor by progesterone contributes to progesterone-induced breast cancer cell proliferation and dedifferentiation.
KLF5 may play an oncogenetic role in gastric carcinogenesis.
Title: Expression of Krűppel-like factor 5 in gastric cancer and its clinical correlation in Taiwan.
Low KLF5 is associated with acute myeloid leukemia.
Title: Deregulated expression of Kruppel-like factors in acute myeloid leukemia.
Data show that results demonstrate that estrogens and antiestrogens affect prostate tumor growth through ERbeta-mediated regulation of KLF5.
Title: Estrogen regulates tumor growth through a nonclassical pathway that includes the transcription factors ERβ and KLF5.
while KLF5 is not required for oncogenic mutant K-Ras-induced lung tumorigenesis, KLF5 regulation of ABCG2 expression may be important for chemotherapeutic resistance and patient survival.
Title: Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival.

Submit: New GeneRIF Correction See all (60)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.

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Products	Interactant	Other Gene	Source	Pubs	Description
Q13887	Q92793	CREBBP	HPRD	PubMed
Q13887	Q09472	EP300	HPRD	PubMed
Q13887	P29084	GTF2E2	HPRD	PubMed
Q13887	P13984	GTF2F2	HPRD	PubMed
Q13887	P19838	NFKB1	HPRD	PubMed
Q13887	Q05655	PRKCD	HPRD	PubMed
Q13887	P10276	RARA	HPRD	PubMed
Q13887	Q01105	SET	HPRD	PubMed
BioGRID:107153	BioGRID:107777	CREBBP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107153	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107153	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107153	BioGRID:108404	ESR2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107153	BioGRID:120581	FBXW7	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:107153	BioGRID:109187	GSK3B	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107153	BioGRID:109214	GTF2B	BioGRID	PubMed	Reconstituted Complex
BioGRID:107153	BioGRID:109217	GTF2F1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107153	BioGRID:109315	HDAC1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107153	BioGRID:109316	HDAC2	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:107153	BioGRID:110857	NFKB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107153	BioGRID:111564	PRKCA	BioGRID	PubMed	Biochemical Activity
BioGRID:107153	BioGRID:111849	RARA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107153	BioGRID:112316	SET	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:107153	BioGRID:122265	SMURF2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:107153	BioGRID:112771	TBP	BioGRID	PubMed	Reconstituted Complex
BioGRID:107153	BioGRID:113500	TRIM25	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107153	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:107153	BioGRID:116243	WWP1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:107153	BioGRID:117434	WWTR1	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
angiogenesis	IEA Inferred from Electronic Annotation more info
microvillus assembly	IEA Inferred from Electronic Annotation more info
positive regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
intracellular	IEA Inferred from Electronic Annotation more info
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: Krueppel-like factor 5

Names: Krueppel-like factor 5; BTE-binding protein 2; GC box binding protein 2; GC-box-binding protein 2; colon kruppel-like factor; colon krueppel-like factor; transcription factor BTEB2; intestinal-enriched kruppel-like factor; intestinal-enriched krueppel-like factor; basic transcription element binding protein 2; basic transcription element-binding protein 2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001730.3 → NP_001721.2 Krueppel-like factor 5

Status: REVIEWED

Source sequence(s)

AF132818, AK131397, BC007695, BC014302

Consensus CDS

CCDS9448.1

UniProtKB/Swiss-Prot

Q13887

UniProtKB/TrEMBL

Q5T6X2

Related

ENSP00000366915, OTTHUMP00000018502, ENST00000377687, OTTHUMT00000045263

Conserved Domains (2) summary

COG5048
Location:359 – 435
Blast Score: 84

COG5048; FOG: Zn-finger [General function prediction only]

pfam13465
Location:419 – 444
Blast Score: 93

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000013.10 Reference GRCh37.p5 Primary Assembly

Range

73633142..73651676

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000145.1 Alternate HuRef

Range

54330388..54348922

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF184924.1	AAG23126.1
genomic	AL354720.14	CAI14871.1
genomic	CH471093.1	EAW80524.1
		EAW80525.1
		EAW80526.1
mRNA	AB030824.1	BAA96461.1
mRNA	AF132818.1	AAF18307.1
mRNA	AF287272.1	AAF88068.1
mRNA	AK131397.1	None
mRNA	AK296900.1	BAG59458.1
mRNA	AK302280.1	BAG63623.1
mRNA	AK304284.1	BAG65143.1
mRNA	BC007695.1	AAH07695.1
mRNA	BC014302.2	None
mRNA	BC042131.1	AAH42131.1
mRNA	BT006641.1	AAP35287.1
mRNA	D14520.1	BAA03393.1
mRNA	EF208215.1	ABM97548.1
other-genetic	DQ890581.2	ABM92198.1
other-genetic	DQ893740.2	ABM84666.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q13887.2	GenPept	UniProtKB/Swiss-Prot:Q13887
Q5T6X2	GenPept	UniProtKB/TrEMBL:Q5T6X2
Q9HBZ3	GenPept	UniProtKB/TrEMBL:Q9HBZ3