TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa [Homo sapiens] - Gene

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Summary

Official Symbol: TAF7provided by HGNC
Official Full Name: TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDaprovided by HGNC
Primary source: HGNC:11541
See related: Ensembl:ENSG00000178913; HPRD:07196; MIM:600573; Vega:OTTHUMG00000129628
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TAF2F; TAFII55
Summary: The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 5q31

Sequence :: Chromosome: 5; NC_000005.9 (140698057..140700351, complement)

See TAF7 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TAF7, until now considered only a TFIID component and regulator of TAF1-dependent transcription, also regulates TAF1-independent transcription
Title: Novel functions for TAF7, a regulator of TAF1-independent transcription.
TAF7 interacts with the transcription factors, TFIIH and P-TEFb, resulting in the inhibition of their Pol II CTD kinase activities
Title: TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb.
TAF7 represents a novel c-Jun co-activator mediating activation of AP-1 target genes in response to extracellular signals
Title: TAF7 (TAFII55) plays a role in the transcription activation by c-Jun.
TAF7 has a role as a basal regulator for mammalian polyamine transport activity and MGBG-induced apoptosis
Title: TATA-binding protein-associated factor 7 regulates polyamine transport activity and polyamine analog-induced apoptosis.
These results suggest normal TBP-binding interactions--specifically recognition, stability, and conformation-are disrupted by CldAMP insertion into eukaryotic promoter sequences.
Title: Presence of the anti-leukemic nucleotide analog, 2-chloro-2'-deoxyadenosine-5'-monophosphate, in a promoter sequence alters DNA binding of TATA-binding protein (TBP).
Functions as a check-point regulator suppressing premature transcription initiation until preinitiation complex assembly is complete.
Title: TAF7: a possible transcription initiation check-point regulator.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47	PubMed
	tat	TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function	PubMed
	tat	A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR	PubMed
	tat	HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro	PubMed
	tat	HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000005.8		CSNK2A1	BIND	PubMed	CK2-alpha interacts with TAF7 promoter.
NC_000005.8	NP_000113.1	ERCC3	BIND	PubMed	TFIIH interacts with TAF7 promoter.
Q15545	P35869	AHR	HPRD	PubMed
Q15545	Q10570	CPSF1	HPRD	PubMed
Q15545	Q00613	HSF1	HPRD	PubMed
Q15545	Q8WTS6	SETD7	HPRD	PubMed
Q15545	P21675	TAF1	HPRD	PubMed
Q15545	Q12962	TAF10	HPRD	PubMed
Q15545	Q15544	TAF11	HPRD	PubMed
Q15545	Q16514	TAF12	HPRD	PubMed
Q15545	Q92804	TAF15	HPRD	PubMed
Q15545	Q6P1X5	TAF2	HPRD	PubMed
Q15545	O00268	TAF4	HPRD	PubMed
Q15545	Q15542	TAF5	HPRD	PubMed
Q15545	P49848	TAF6	HPRD	PubMed
Q15545	Q15545	TAF7	HPRD	PubMed
Q15545	Taube nuss	TAF8	HPRD	PubMed
Q15545	Q16594	TAF9	HPRD	PubMed
Q15545	O15164	TRIM24	HPRD	PubMed
BioGRID:112742	BioGRID:107343	CCNT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112742	BioGRID:107457	CDK7	BioGRID	PubMed	Reconstituted Complex
BioGRID:112742	BioGRID:107459	CDK9	BioGRID	PubMed	Reconstituted Complex
BioGRID:112742	BioGRID:118946	CPSF1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112742	BioGRID:108893	GATA1	BioGRID	PubMed	Two-hybrid
BioGRID:112742	BioGRID:114089	IKBKG	BioGRID	PubMed	Two-hybrid
BioGRID:112742	BioGRID:123565	MAP1LC3B	BioGRID	PubMed	Two-hybrid
BioGRID:112742	BioGRID:123332	SETD7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112742	BioGRID:112735	TAF1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:112742	BioGRID:112744	TAF10	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-purification
BioGRID:112742	BioGRID:113807	TAF15	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112742	BioGRID:123775	TAF3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112742	BioGRID:112740	TAF5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112742	BioGRID:126205	TAF8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112742	BioGRID:112743	TAF9	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112742	BioGRID:112771	TBP	BioGRID	PubMed	Affinity Capture-RNA; Affinity Capture-Western; Co-purification; Reconstituted Complex
BioGRID:112742	BioGRID:112923	THRA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112742	BioGRID:115628	TRIM22	BioGRID	PubMed	Two-hybrid
BioGRID:112742	BioGRID:114333	TRIM24	BioGRID	PubMed	Biochemical Activity
BioGRID:112742	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112742	BioGRID:113264	VDR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112742	BioGRID:129825	ZSCAN1	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
histone acetyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
thyroid hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed
vitamin D receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
intracellular estrogen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
negative regulation of histone acetylation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
spermine transport	ISS Inferred from Sequence or Structural Similarity more info
transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
transcription initiation from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
transcription initiation, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
MLL1 complex	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with positive transcription elongation factor complex b	IDA Inferred from Direct Assay more info	PubMed
transcription factor TFIID complex	IDA Inferred from Direct Assay more info	PubMed
transcription factor TFTC complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: transcription initiation factor TFIID subunit 7

Names: transcription initiation factor TFIID subunit 7; TAFII-55; TAF(II)55; TBP-associated factor F; transcription factor IID subunit TAFII55; RNA polymerase II TBP-associated factor subunit F; transcription initiation factor TFIID 55 kDa subunit; transcription initiation factor TFIID, 55 kDa subunit; TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_000012.2 Reference

Range

28687..30981, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_005642.2 → NP_005633.2 transcription initiation factor TFIID subunit 7

Status: REVIEWED

Source sequence(s)

AF349038

Consensus CDS

CCDS4259.1

UniProtKB/Swiss-Prot

Q15545

Related

ENSP00000312709, OTTHUMP00000160028, ENST00000313368, OTTHUMT00000251823

Conserved Domains (1) summary

cd08047
Location:13 – 184
Blast Score: 447

TAF7; TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

140698057..140700351, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

135843117..135845411, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC005618.1 (30000..32294)	None
genomic	AF349038.1	AAK30585.1
genomic	CH471062.2	EAW61966.1
genomic	Z65839.1	None
genomic	Z65840.1	None
mRNA	AK314837.1	BAG37356.1
mRNA	BC013397.2	None
mRNA	BC022798.1	AAH22798.1
mRNA	BC032737.1	AAH32737.1
mRNA	U18062.1	AAB60347.1
mRNA	X97999.1	CAA66636.1
other-genetic	DQ890889.2	ABM81815.1
other-genetic	DQ894044.2	ABM84970.1