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TAF6 TATA-box binding protein associated factor 6 [ Homo sapiens (human) ]

Gene ID: 6878, updated on 12-May-2016
Official Symbol
TAF6provided by HGNC
Official Full Name
TATA-box binding protein associated factor 6provided by HGNC
Primary source
HGNC:HGNC:11540
See related
Ensembl:ENSG00000106290 HPRD:11807; MIM:602955; Vega:OTTHUMG00000154771
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAF2E; TAFII70; TAFII80; TAFII85; MGC:8964; TAFII-70; TAFII-80; TAF(II)70; TAF(II)80
Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Orthologs
Location:
7q22.1
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (100107070..100119858, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99704693..99717481, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene microRNA 106b Neighboring gene minichromosome maintenance complex component 7 Neighboring gene microRNA 93 Neighboring gene adaptor related protein complex 4 mu 1 subunit Neighboring gene uncharacterized LOC105375424 Neighboring gene canopy FGF signaling regulator 4 Neighboring gene uncharacterized LOC105375425 Neighboring gene metallo-beta-lactamase domain containing 1 Neighboring gene ribosomal protein L7 pseudogene 60

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
tat TFIID subunit TAF6 binds to the TATA box and adjacent sequences (including E-box) of HIV-1 LTR, which contains nucleotides from -33 to -16 with respect to the transcriptional start site PubMed
tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp781E21155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFTC complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
transcription initiation factor TFIID subunit 6
Names
RNA polymerase II TBP-associated factor subunit E
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD
TATA box binding protein associated factor 6
transcription initiation factor TFIID 70 kDa subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029454.1 RefSeqGene

    Range
    5001..17789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001190415.1NP_001177344.1  transcription initiation factor TFIID subunit 6 isoform epsilon

    See identical proteins and their annotated locations for NP_001177344.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (epsilon) has a distinct N-terminus and is longer than isoform alpha.
    Source sequence(s)
    AK300005, CX782724, DC339989
    Consensus CDS
    CCDS55135.1
    UniProtKB/Swiss-Prot
    P49848
    Related
    ENSP00000399982, OTTHUMP00000206714, ENST00000437822, OTTHUMT00000337137
    Conserved Domains (1) summary
    cd08050
    Location:52425
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  2. NM_005641.3NP_005632.1  transcription initiation factor TFIID subunit 6 isoform alpha

    See identical proteins and their annotated locations for NP_005632.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (alpha). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    CX782724, DA707589, L25444
    Consensus CDS
    CCDS5686.1
    UniProtKB/Swiss-Prot
    P49848
    Related
    ENSP00000344537, OTTHUMP00000206641, ENST00000344095, OTTHUMT00000337024
    Conserved Domains (1) summary
    cd08050
    Location:15388
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  3. NM_139315.2NP_647476.1  transcription initiation factor TFIID subunit 6 isoform alpha

    See identical proteins and their annotated locations for NP_647476.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (alpha).
    Source sequence(s)
    BC018115, CX782724, DA150478, DA776355
    Consensus CDS
    CCDS5686.1
    UniProtKB/Swiss-Prot
    P49848
    Related
    ENSP00000389575, OTTHUMP00000206716, ENST00000453269, OTTHUMT00000337139
    Conserved Domains (1) summary
    cd08050
    Location:15388
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

RNA

  1. NR_033792.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has a different 5'-most exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to inhibit the translation of the downstream primary ORF, as found in variant 1.
    Source sequence(s)
    AC073842, BC018115, CX782724, DA707589
    Related
    ENST00000421980, OTTHUMT00000337138

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    100107070..100119858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516542.1XP_011514844.1  

    See identical proteins and their annotated locations for XP_011514844.1

    UniProtKB/TrEMBL
    A4D299
    Conserved Domains (1) summary
    cd08050
    Location:15378
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  2. XM_006716100.1XP_006716163.1  

    See identical proteins and their annotated locations for XP_006716163.1

    UniProtKB/Swiss-Prot
    P49848
    Conserved Domains (1) summary
    cd08050
    Location:15388
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  3. XM_006716101.1XP_006716164.1  

    See identical proteins and their annotated locations for XP_006716164.1

    UniProtKB/TrEMBL
    A4D299
    Conserved Domains (1) summary
    cd08050
    Location:15378
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  4. XM_006716102.1XP_006716165.1  

    See identical proteins and their annotated locations for XP_006716165.1

    UniProtKB/TrEMBL
    A4D299
    Conserved Domains (1) summary
    cd08050
    Location:15378
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
  5. XM_011516543.1XP_011514845.1  

    See identical proteins and their annotated locations for XP_011514845.1

    UniProtKB/TrEMBL
    A4D299
    Conserved Domains (1) summary
    cd08050
    Location:15378
    TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    99634850..99647636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_139122.1: Suppressed sequence

    Description
    NM_139122.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_139123.1: Suppressed sequence

    Description
    NM_139123.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.