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    Acss1 acyl-CoA synthetase short-chain family member 1 [ Mus musculus (house mouse) ]

    Gene ID: 68738, updated on 18-May-2013
    Official Symbol
    Acss1provided by MGI
    Official Full Name
    acyl-CoA synthetase short-chain family member 1provided by MGI
    Primary source
    MGI:1915988
    Locus tag
    RP23-156P22.4
    See related
    Ensembl:ENSMUSG00000027452; Vega:OTTMUSG00000015731
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acas2; Acas2l; AceCS2; AI788978; 1110032O15Rik
    Location :
    2 G3; 2
    Sequence :
    Chromosome: 2; NC_000068.7 (150618111..150668240, complement)
    See Acss1 in Epigenomics, MapViewer

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene cystatin F (leukocystatin) Neighboring gene adipocyte plasma membrane associated protein Neighboring gene RIKEN cDNA E130215H24 gene Neighboring gene visual system homeobox 1 homolog (zebrafish) Neighboring gene ectonucleoside triphosphate diphosphohydrolase 6

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750.
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068.
    3. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288.
    4. Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2. Sakakibara I, et al. Cell Metab, 2009 Feb. PMID 19187775.
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015.

    See all (26) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Findings demonstrate that activation of acetate by AceCS2 plays a pivotal role in thermogenesis, especially under low-glucose or ketogenic conditions, and is crucially required for survival.
      Title: Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.
    2. together with the trans-activation of the AceCS2 promoter, it is suggested that fasting-induced AceCS2 expression is largely contributed by KLF15
      Title: A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    AMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acetate-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acetate-CoA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acetate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acetyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acetyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acetyl-CoA biosynthetic process from acetate IEA
    Inferred from Electronic Annotation
    more info
    		  
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    propionate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		  
    mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Preferred Names
    acetyl-coenzyme A synthetase 2-like, mitochondrial
    Names
    acetyl-coenzyme A synthetase 2-like, mitochondrial
    acetate--CoA ligase 2
    acetyl-CoA synthetase 2
    NP_542142.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080575.2 → NP_542142.1  acetyl-coenzyme A synthetase 2-like, mitochondrial precursor

      Status: VALIDATED

      Source sequence(s)
      AK146568, AK173275
      Consensus CDS
      CCDS16859.1
      UniProtKB/TrEMBL
      Q569W4
      UniProtKB/TrEMBL
      Q69Z91
      UniProtKB/Swiss-Prot
      Q99NB1
      Related
      ENSMUSP00000028944, OTTMUSP00000016746, ENSMUST00000028944, OTTMUST00000037370
      Conserved Domains (4) summary
      TIGR02188
      Location:45 – 670
      Blast Score: 2737
      Ac_CoA_lig_AcsA; acetate--CoA ligase
      pfam00501
      Location:135 – 573
      Blast Score: 889
      AMP-binding; AMP-binding enzyme
      pfam11930
      Location:65 – 127
      Blast Score: 198
      DUF3448; Domain of unknown function (DUF3448)
      pfam13193
      Location:616 – 660
      Blast Score: 194
      DUF4009; Domain of unknown function (DUF4009)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p1 C57BL/6J

      Range
      150618111..150668240, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000024.1 Alternate Mm_Celera

      Range
      151852988..151903233, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01021962.1 None
    genomic AAHY01021963.1 None
    genomic AAHY01021964.1 (30874..52930) None
    genomic AL845174.4 (62491..112620) None
    genomic CH466519.1 EDL28571.1 mixed
      EDL28572.1 mixed
    genomic HC890901.1 CBN59938.1
    genomic HC895433.1 CBN62155.1
    mRNA AB046742.1 BAB21612.1
    mRNA AK004042.1 None C57BL/6J
    mRNA AK088244.1 BAC40232.1 NOD
    mRNA AK146568.1 BAE27266.1 C57BL/6J
    mRNA AK158119.1 BAE34365.1 C57BL/6J
    mRNA AK172412.1 BAE42994.1 NOD
    mRNA AK172470.1 BAE43023.1 NOD
    mRNA AK173275.1 BAD32553.1
    mRNA BC004097.1 AAH04097.1 FVB/N
    mRNA BC030930.1 AAH30930.1 FVB/N
    mRNA BC092278.1 AAH92278.1 FVB/N
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99NB1.1 GenPept UniProtKB/Swiss-Prot:Q99NB1

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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