Acss1 acyl-CoA synthetase short-chain family member 1 [Mus musculus] - Gene

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Summary

Official Symbol: Acss1provided by MGI
Official Full Name: acyl-CoA synthetase short-chain family member 1provided by MGI
Primary source: MGI:1915988
Locus tag: RP23-156P22.4
See related: Ensembl:ENSMUSG00000027452; Vega:OTTMUSG00000015731
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acas2; Acas2l; AceCS2; AI788978; 1110032O15Rik

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Genomic context

Location :: 2 G3; 2

Sequence :: Chromosome: 2; NC_000068.7 (150618111..150668240, complement)

See Acss1 in Epigenomics, MapViewer

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings demonstrate that activation of acetate by AceCS2 plays a pivotal role in thermogenesis, especially under low-glucose or ketogenic conditions, and is crucially required for survival.
Title: Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.
together with the trans-activation of the AceCS2 promoter, it is suggested that fasting-induced AceCS2 expression is largely contributed by KLF15
Title: A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.

Submit: New GeneRIF Correction

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

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Function	Evidence Code	Pubs
AMP binding	IEA Inferred from Electronic Annotation more info
ATP binding	IEA Inferred from Electronic Annotation more info
acetate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
acetate-CoA ligase activity	ISO Inferred from Sequence Orthology more info
catalytic activity	IEA Inferred from Electronic Annotation more info
ligase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acetate biosynthetic process	ISO Inferred from Sequence Orthology more info
acetyl-CoA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
acetyl-CoA biosynthetic process	ISO Inferred from Sequence Orthology more info
metabolic process	IEA Inferred from Electronic Annotation more info
propionate biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
mitochondrial matrix	IDA Inferred from Direct Assay more info
mitochondrial matrix	ISO Inferred from Sequence Orthology more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: acetyl-coenzyme A synthetase 2-like, mitochondrial

Names: acetyl-coenzyme A synthetase 2-like, mitochondrial; acetate--CoA ligase 2; acetyl-CoA synthetase 2

NP_542142.1

EC 6.2.1.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080575.2 → NP_542142.1 acetyl-coenzyme A synthetase 2-like, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

AK146568, AK173275

Consensus CDS

CCDS16859.1

UniProtKB/TrEMBL

Q569W4

UniProtKB/TrEMBL

Q69Z91

UniProtKB/Swiss-Prot

Q99NB1

Related

ENSMUSP00000028944, OTTMUSP00000016746, ENSMUST00000028944, OTTMUST00000037370

Conserved Domains (4) summary

TIGR02188
Location:45 – 670
Blast Score: 2737

Ac_CoA_lig_AcsA; acetate--CoA ligase

pfam11930
Location:65 – 127
Blast Score: 198

DUF3448; Domain of unknown function (DUF3448)

cl09925
Location:616 – 660
Blast Score: 194

PKc_like; Protein Kinases, catalytic domain

cl15778
Location:135 – 573
Blast Score: 889

AMP-binding; AMP-binding enzyme

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38 C57BL/6J

Range

150618111..150668240, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000024.1 Alternate Mm_Celera

Range

151852988..151903233, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AL845174.4	CAM15680.1
genomic	CH466519.1	EDL28571.1	mixed
		EDL28572.1	mixed
genomic	HC890901.1	CBN59938.1
genomic	HC895433.1	CBN62155.1
mRNA	AB046742.1	BAB21612.1
mRNA	AK004042.1	None	C57BL/6J
mRNA	AK088244.1	BAC40232.1	NOD
mRNA	AK146568.1	BAE27266.1	C57BL/6J
mRNA	AK158119.1	BAE34365.1	C57BL/6J
mRNA	AK172412.1	BAE42994.1	NOD
mRNA	AK172470.1	BAE43023.1	NOD
mRNA	AK173275.1	BAD32553.1
mRNA	BC004097.1	AAH04097.1	FVB/N
mRNA	BC030930.1	AAH30930.1	FVB/N
mRNA	BC092278.1	AAH92278.1	FVB/N

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q3TZ45	GenPept	UniProtKB/TrEMBL:Q3TZ45
Q569W4	GenPept	UniProtKB/TrEMBL:Q569W4
Q69Z91	GenPept	UniProtKB/TrEMBL:Q69Z91
Q99KM8	GenPept	UniProtKB/TrEMBL:Q99KM8
Q99NB1.1	GenPept	UniProtKB/Swiss-Prot:Q99NB1