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TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa [ Homo sapiens (human) ]

Gene ID: 6873, updated on 12-May-2015
Official Symbol
TAF2provided by HGNC
Official Full Name
TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDaprovided by HGNC
Primary source
HGNC:HGNC:11536
See related
Ensembl:ENSG00000064313; HPRD:07060; MIM:604912; Vega:OTTHUMG00000165009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRT40; TAF2B; CIF150; TAFII150
Summary
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]
Orthologs
See TAF2 in MapViewer
Location:
8q24.12
Exon count:
27
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (119730773..119832858, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (120743014..120845074, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 2 Neighboring gene cytochrome c, somatic pseudogene 23 Neighboring gene uncharacterized LOC105375727 Neighboring gene uncharacterized LOC105375728 Neighboring gene DNA replication and sister chromatid cohesion 1 Neighboring gene RNA, 5S ribosomal pseudogene 277 Neighboring gene DEP domain containing MTOR-interacting protein

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
gene expression TAS
Traceable Author Statement
more info
 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
transcription elongation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nucleoplasm TAS
Traceable Author Statement
more info
 
transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
NOT transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor TFTC complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
transcription initiation factor TFIID subunit 2
Names
transcription initiation factor TFIID subunit 2
150 kDa cofactor of initiator function
RNA polymerase II TBP-associated factor subunit B
TAF(II)150
TATA box binding protein (TBP)-associated factor, RNA polymerase II, B, 150kD
TBP-associated factor 150 kDa
cofactor of initiator function, 150kD subunit
transcription initiation factor TFIID 150 kDa subunit

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033911.1 RefSeqGene

    Range
    5001..107061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003184.3NP_003175.1  transcription initiation factor TFIID subunit 2

    See identical proteins and their annotated locations for NP_003175.1

    Status: REVIEWED

    Source sequence(s)
    AF040701, AK001618, BC008473, BC035673, BC047732, BC064830
    Consensus CDS
    CCDS34937.1
    UniProtKB/TrEMBL
    B3KMD8
    UniProtKB/Swiss-Prot
    Q6P1X5
    Related
    ENSP00000367406, OTTHUMP00000228190, ENST00000378164, OTTHUMT00000381436
    Conserved Domains (1) summary
    cd09839
    Location:27541
    M1_TAF2; TATA binding protein (TBP) associated factor 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    119730773..119832858
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517259.1XP_011515561.1  

    Conserved Domains (1) summary
    cd09839
    Location:27541
    M1_TAF2; TATA binding protein (TBP) associated factor 2
  2. XM_006716621.2XP_006716684.1  

    Conserved Domains (1) summary
    cd09839
    Location:27541
    M1_TAF2; TATA binding protein (TBP) associated factor 2
  3. XM_011517262.1XP_011515564.1  

    Conserved Domains (1) summary
    cl14813
    Location:14124
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  4. XM_011517261.1XP_011515563.1  

    Conserved Domains (1) summary
    cl14813
    Location:1330
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
  5. XM_011517260.1XP_011515562.1  

    Conserved Domains (1) summary
    cd09839
    Location:2372
    M1_TAF2; TATA binding protein (TBP) associated factor 2

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    120783731..120885905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)