KLF9 Kruppel-like factor 9 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: KLF9provided by HGNC
Official Full Name: Kruppel-like factor 9provided by HGNC
Primary source: HGNC:1123
See related: Ensembl:ENSG00000119138; HPRD:04211; MIM:602902; Vega:OTTHUMG00000019991
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BTEB; BTEB1
Summary: The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 9q13

Sequence :: Chromosome: 9; NC_000009.11 (72999513..73029573, complement)

See KLF9 in Epigenomics, MapViewer

Chromosome 9 - NC_000009.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Klf9 affects keratinocyte proliferation/differentiation by controlling the expression of target genes in a daytime-dependent manner.
Title: Krüppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes.
It was suggested that KLF9 loss-of-expression accompanying endometrial carcinogenesis may predispose endometrial epithelial cells to mechanisms of escape from estrogen-mediated growth regulation, leading to progression of established neoplasms.
Title: Krüppel-like factor 9 loss-of-expression in human endometrial carcinoma links altered expression of growth-regulatory genes with aberrant proliferative response to estrogen.
Loss of KLF9 coregulation of endometrial stromal progesterone receptor-responsive gene networks may underlie progesterone resistance in endometriosis.
Title: Krüppel-like factor 9 and progesterone receptor coregulation of decidualizing endometrial stromal cells: implications for the pathogenesis of endometriosis.
Data identify KLF9 as a novel and potentially clinically relevant transcriptional regulator of drug-induced apoptosis in multiple myeloma cells.
Title: KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells.
Expression levels of HOXA11, LIF and BTEB1 mRNA were measured in endometrium during the mid-secretory phase using semi-quantitative RT-PCR
Title: Semi-quantitative analysis of HOXA11, leukemia inhibitory factor and basic transcriptional element binding protein 1 mRNA expression in the mid-secretory endometrium of patients with endometriosis.
these results show for the first time that KLF9 has differentiating and tumor-suppressing functions in tumor-initiating stem cells.
Title: Krüppel-like family of transcription factor 9, a differentiation-associated transcription factor, suppresses Notch1 signaling and inhibits glioblastoma-initiating stem cells.
homeobox A10(HOXA10) directly and selectively repressed Kruppel-like factor 9 expression in endometrial epithelial cells
Title: HOXA10 inhibits Kruppel-like factor 9 expression in the human endometrial epithelium.
Data support cross-regulation among BMP2, KLF9, and KLF13 to maintain progesterone sensitivity in stromal cells undergoing differentiation and suggest that loss of this network compromises establishment of uterine receptivity and implantation success.
Title: Functional differentiation of uterine stromal cells involves cross-regulation between bone morphogenetic protein 2 and Kruppel-like factor (KLF) family members KLF9 and KLF13.
T3-induced genes identified basic transcription element binding protein 1/Kruppel-like factor 9 (BTEB1/KLF9) and GAR22 as TR target genes
Title: GAR22: a novel target gene of thyroid hormone receptor causes growth inhibition in human erythroid cells.
KLF9 influences the expression of uterine epithelial genes through mechanisms likely involving its transcriptional activator and repressor functions and which may underlie altered tumor biology with aberrant KLF9 expression.
Title: The Krüppel-like factor 9 (KLF9) network in HEC-1-A endometrial carcinoma cells suggests the carcinogenic potential of dys-regulated KLF9 expression.

Submit: New GeneRIF Correction See all (16)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Tat, p14	tat	BTEB enhances HIV-1 Tat transactivation of the HIV-1 LTR promoter	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001197.1		PGR	BIND	PubMed	KLF9 (BTEB1) interacts with PGR (PR-B).
Q13886	P06401	PGR	HPRD	PubMed
BioGRID:107152	BioGRID:108309	ELAVL1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:107152	BioGRID:119613	HDAC7	BioGRID	PubMed	Negative Genetic
BioGRID:107152	BioGRID:111260	PGR	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:107152	BioGRID:117439	SIN3A	BioGRID	PubMed	Reconstituted Complex
BioGRID:107152	BioGRID:112550	SP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107152	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Diurnally regulated genes with circadian orthologs, organism-specific biosystem (from WikiPathways)
Diurnally regulated genes with circadian orthologs, organism-specific biosystemHuman genes regulated in the diurnal comparison with orthologues that display circadian regulation in mouse heart and liver (Panda 2002, Storch 2002), and SCN (Panda 2002). The 608 significantly regu...

General gene information

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Markers

WI-20373 (e-PCR)
- UniSTS:22070

NoName (e-PCR)
- UniSTS:481611

RH80755 (e-PCR)
- UniSTS:89271

D9S2058 (e-PCR)
- UniSTS:35532

D9S2095 (e-PCR)
- UniSTS:82920

NoName (e-PCR)
- UniSTS:482032

Homology

Homologs of the KLF9 gene: The KLF9 gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, and chicken.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
cellular response to thyroid hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
embryo implantation	IEA Inferred from Electronic Annotation more info
progesterone receptor signaling pathway	IEA Inferred from Electronic Annotation more info
regulation of transcription from RNA polymerase II promoter	TAS Traceable Author Statement more info	PubMed
transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Krueppel-like factor 9

Names: Krueppel-like factor 9; BTE-binding protein 1; GC-box-binding protein 1; transcription factor BTEB1; basic transcription element binding protein 1; basic transcription element-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001206.2 → NP_001197.1 Krueppel-like factor 9

Status: REVIEWED

Source sequence(s)

AI458659, AI693223, AL162390, BC069431, BE221978

Consensus CDS

CCDS6633.1

UniProtKB/Swiss-Prot

Q13886

Related

ENSP00000366330, OTTHUMP00000021441, ENST00000377126, OTTHUMT00000052602

Conserved Domains (3) summary

COG5048
Location:139 – 234
Blast Score: 92

COG5048; FOG: Zn-finger [General function prediction only]

pfam13465
Location:189 – 212
Blast Score: 94

zf-H2C2_2; Zinc-finger double domain

cl15478
Location:203 – 225
Blast Score: 72

zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000009.11 Reference GRCh37.p10 Primary Assembly

Range

72999513..73029573, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000141.1 Alternate HuRef

Range

42839584..42869749, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018920.1 Alternate CHM1_1.0

Range

72901249..72931247, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01033823.1 (14266..44431)	None
genomic	AL162390.9 (150367..180427)	None
genomic	AMYH01021394.1 (543351..573349)	None
genomic	CH471089.1	EAW62503.1
		EAW62504.1
genomic	CQ834782.1	CAH05606.1
mRNA	AB451404.1	BAG70218.1
mRNA	AI458659.1	None
mRNA	AI693223.1	None
mRNA	AK313631.1	BAG36390.1
mRNA	BC069431.1	AAH69431.1
mRNA	BC074879.2	AAH74879.1
mRNA	BC074880.2	AAH74880.1
mRNA	BE221978.1	None
mRNA	D31716.1	BAA06524.1
mRNA	S72504.1	AAD14110.1
other-genetic	EU446889.1	ABZ92418.1