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KLF9 Kruppel-like factor 9 [ Homo sapiens (human) ]

Gene ID: 687, updated on 17-Feb-2015
Official Symbol
KLF9provided by HGNC
Official Full Name
Kruppel-like factor 9provided by HGNC
Primary source
HGNC:HGNC:1123
See related
Ensembl:ENSG00000119138; HPRD:04211; MIM:602902; Vega:OTTHUMG00000019991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTEB; BTEB1
Summary
The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]
Orthologs
See KLF9 in MapViewer
Location:
9q13
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 9 NC_000009.12 (70384597..70414657, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (72999513..73029573, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene MAM domain containing 2 Neighboring gene SMC5 antisense RNA 1 (head to head) Neighboring gene ribosomal protein L24 pseudogene 8 Neighboring gene structural maintenance of chromosomes 5 Neighboring gene uncharacterized LOC101927086 Neighboring gene transient receptor potential cation channel, subfamily M, member 3 Neighboring gene microRNA 204

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat BTEB enhances HIV-1 Tat transactivation of the HIV-1 LTR promoter PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular response to cortisol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to thyroid hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
progesterone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
Krueppel-like factor 9
Names
Krueppel-like factor 9
BTE-binding protein 1
GC-box-binding protein 1
basic transcription element binding protein 1
basic transcription element-binding protein 1
transcription factor BTEB1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206.2NP_001197.1  Krueppel-like factor 9

    See proteins identical to NP_001197.1

    Status: REVIEWED

    Source sequence(s)
    AI458659, AI693223, AL162390, BC069431, BE221978
    Consensus CDS
    CCDS6633.1
    UniProtKB/TrEMBL
    A0A024R260
    UniProtKB/Swiss-Prot
    Q13886
    Related
    ENSP00000366330, OTTHUMP00000021441, ENST00000377126, OTTHUMT00000052602
    Conserved Domains (2) summary
    COG5048
    Location:94234
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam13465
    Location:189212
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38 Primary Assembly

    Range
    70384597..70414657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    73146053..73176110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000141.1 Alternate HuRef

    Range
    42839584..42869749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)