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    TACC1 transforming, acidic coiled-coil containing protein 1 [ Homo sapiens ]

    Gene ID: 6867, updated on 11-May-2012
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    Summary

    Official Symbol
    TACC1provided by HGNC
    Official Full Name
    transforming, acidic coiled-coil containing protein 1provided by HGNC
    Primary source
    HGNC:11522
    See related
    Ensembl:ENSG00000147526; HPRD:10391; MIM:605301; Vega:OTTHUMG00000164018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Ga55; FLJ42304; KIAA1103; DKFZp686K18126
    Summary
    This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
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    Genomic context

    Location :
    8p11.22
    Sequence :
    Chromosome: 8; NC_000008.10 (38585704..38710546)
    See TACC1 in Epigenomics, MapViewer

    Chromosome 8 - NC_000008.10Genomic Context describing neighboring genes Neighboring gene chromosome 8 open reading frame 86 Neighboring gene ring finger protein 5, E3 ubiquitin protein ligase pseudogene 1 Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 Neighboring gene HtrA serine peptidase 4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein. Gabillard JC, et al. Biochem Biophys Res Commun, 2011 May 20. PMID 21531210.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. A large-scale candidate gene association study of age at menarche and age at natural menopause. He C, et al. Hum Genet, 2010 Nov. PMID 20734064.
    5. Centrosome-related genes, genetic variation, and risk of breast cancer. Olson JE, et al. Breast Cancer Res Treat, 2011 Jan. PMID 20508983.

    See all (30) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. the study demonstrated that TACC1 localizes at the midbody during cytokinesis and interacts with and is a substrate of Aurora-C, which warrant further investigation in order to elucidate the functional significance of this interaction.
      Title: Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: A large-scale candidate gene association study of age at menarche and age at natural menopause.
    3. TACC1 depletion in the cell led to decreased RARalpha and TRalpha ligand-dependent transcriptional activity and to delocalization of TR from the nucleus to the cytoplasm.
      Title: The transforming acidic coiled coil (TACC1) protein modulates the transcriptional activity of the nuclear receptors TR and RAR.
    4. TACC1 and a three-gene expression signature (TACC1, NOV, and PTTG1) were identified as independent prognostic markers.
      Title: Identification of TACC1, NOV, and PTTG1 as new candidate genes associated with endocrine therapy resistance in breast cancer.
    5. Splice variants can be localized to different subcellular compartments in a cell-and tissue-specific manner.
      Title: Temporal and spatial expression of TACC1 in the mouse and human.
    6. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells
      Title: Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells.
    7. Down regulation of tacc1 controls mrna homeostasis in polarized cells and participates in oncogenic processes in human cancers
      Title: Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators.
    8. Splicing pattern of its mRNA is altered in stomach cancer
      Title: Altered splicing pattern of TACC1 mRNA in gastric cancer.
    9. REVIEW: genetics, expression, gene expression regulation, and function studies
      Title: AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains.
    10. TACC1 and the mitotic kinase Aurora B belong to the same complex during cytokinesis.
      Title: Aurora B -TACC1 protein complex in cytokinesis.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_006274.1 NP_066564.1 KAT2A    BIND  PubMed TACC1 interacts with hGCN5L2. 
    O75410 O14965 AURKA    HPRD  PubMed  
    O75410 Q96GD4 AURKB    HPRD  PubMed  
    O75410 Q92830 KAT2A    HPRD  PubMed  
    O75410 Q9UK45 LSM7    HPRD  PubMed  
    O75410 P62308 SNRPG    HPRD  PubMed  
    O75410 O75410 TACC1    HPRD  PubMed  
    O75410 Q8NHU6 TDRD7    HPRD  PubMed  
    O75410 O95619 YEATS4    HPRD  PubMed  
    BioGRID:112730 BioGRID:112666 AURKA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112730 BioGRID:114646 AURKB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112730 BioGRID:107056 BARD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112730 BioGRID:115137 CKAP5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112730 BioGRID:108918 KAT2A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112730 BioGRID:119678 LSM7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112730 BioGRID:112521 SNRPG    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112730 BioGRID:116994 TDRD7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112730 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112730 BioGRID:113761 YEATS4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
    		  
    interkinetic nuclear migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    transforming acidic coiled-coil-containing protein 1
    Names
    transforming acidic coiled-coil-containing protein 1
    taxin-1
    gastric cancer antigen Ga55
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122824.1 → NP_001116296.1  transforming acidic coiled-coil-containing protein 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple coding exons in the 5' end, compared to variant (1). The encoded protein (isoform 2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AY139007, AY177411, DB084271
      Consensus CDS
      CCDS47845.1
      UniProtKB/Swiss-Prot
      O75410
      Related
      ENSP00000276520, OTTHUMP00000225587, ENST00000276520, OTTHUMT00000376769
      Conserved Domains (1) summary
      pfam05010
      Location:187 – 393
      Blast Score: 669
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    2. NM_001146216.2 → NP_001139688.1  transforming acidic coiled-coil-containing protein 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AB029026, AC067817, AY072876, BX647696
      Consensus CDS
      CCDS55224.1
      UniProtKB/Swiss-Prot
      O75410
      UniProtKB/TrEMBL
      Q5HYH0
      Related
      ENSP00000428450, OTTHUMP00000225581, ENST00000520615, OTTHUMT00000376760
      Conserved Domains (1) summary
      pfam05010
      Location:402 – 608
      Blast Score: 753
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    3. NM_006283.2 → NP_006274.2  transforming acidic coiled-coil-containing protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF049910, AY072876, AY139007, DB084271
      Consensus CDS
      CCDS6109.1
      UniProtKB/Swiss-Prot
      O75410
      Related
      ENSP00000321703, OTTHUMP00000225586, ENST00000317827, OTTHUMT00000376768
      Conserved Domains (1) summary
      pfam05010
      Location:597 – 803
      Blast Score: 772
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000008.10 Reference GRCh37.p5 Primary Assembly

      Range
      38585704..38710546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000140.1 Alternate HuRef

      Range
      37121058..37245998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC016813.20 (23551..58020) None
    genomic AC067817.10 (41617..107383) None
    genomic CH471080.2 EAW63293.1
      EAW63294.1
      EAW63295.1
      EAW63296.1
      EAW63297.1
      EAW63298.1
    mRNA AB029026.1 BAA83055.1
    mRNA AF049910.1 AAC32327.1
    mRNA AF075051.1 None
    mRNA AK124297.1 None
    mRNA AK294931.1 BAG58010.1
    mRNA AK295071.1 BAG58118.1
    mRNA AK295841.1 BAH12199.1
    mRNA AK303596.1 BAG64611.1
    mRNA AK304507.1 BAG65314.1
    mRNA AK304725.1 BAG65488.1
    mRNA AK304774.1 BAG65529.1
    mRNA AK308849.1 None
    mRNA AK314620.1 BAG37186.1
    mRNA AY039239.1 AAK68658.1
    mRNA AY072873.2 AAL62460.2
    mRNA AY072874.1 AAL62461.1
    mRNA AY072875.1 AAL62462.1
    mRNA AY072876.2 AAL62463.2
    mRNA AY139007.1 AAN28955.1
    mRNA AY177411.1 AAO53446.1
    mRNA BC041391.1 AAH41391.1
    mRNA BX647696.1 CAI46025.1
    mRNA DA553264.1 None
    mRNA DB084271.1 None
    other-genetic JF432777.1 ADZ15994.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75410.2 GenPept UniProtKB/Swiss-Prot:O75410
    Q5HYH0 GenPept UniProtKB/TrEMBL:Q5HYH0
    Q8IUJ5 GenPept UniProtKB/TrEMBL:Q8IUJ5
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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