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TAC3 tachykinin 3 [ Homo sapiens (human) ]

Gene ID: 6866, updated on 8-May-2016
Official Symbol
TAC3provided by HGNC
Official Full Name
tachykinin 3provided by HGNC
Primary source
HGNC:HGNC:11521
See related
Ensembl:ENSG00000166863 HPRD:08877; MIM:162330; Vega:OTTHUMG00000156958
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKB; HH10; NKNB; PRO1155; ZNEUROK1
Summary
This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
Orthologs
Location:
12q13.3
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (57009997..57016560, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57403781..57410344, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 182 Neighboring gene HBcAg-binding protein Neighboring gene zinc finger and BTB domain containing 39 Neighboring gene myosin IA Neighboring gene nuclear envelope integral membrane protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Tachykinin receptors bind tachykinins, organism-specific biosystem (from REACTOME)
    Tachykinin receptors bind tachykinins, organism-specific biosystemTachykinin peptides are one of the largest family of neuropeptides, so named due to their ability to rapidly induce contraction of gut tissue. Tachykinins excite neurons, elicit behavioural responses...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
female pregnancy TAS
Traceable Author Statement
more info
PubMed 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
tachykinin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
tachykinin-3
Names
gamma tachykinin 3
neurokinin b
neuromedin K
preprotachykinin B
preprotachykinin-B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021398.1 RefSeqGene

    Range
    5001..11564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178054.1NP_001171525.1  tachykinin-3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001171525.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter and lacks the entire Neurokinin-B peptide compared to isoform 1. The encoded isoform (2) and may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AF537121, BE500999, BP212420
    Consensus CDS
    CCDS53803.1
    UniProtKB/Swiss-Prot
    Q9UHF0
    UniProtKB/TrEMBL
    A0A024RB97
    Related
    ENSP00000408208, OTTHUMP00000211127, ENST00000441881, OTTHUMT00000346798
    Conserved Domains (1) summary
    pfam03823
    Location:155
    Neurokinin_B; Neurokinin B
  2. NM_013251.3NP_037383.1  tachykinin-3 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_037383.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC032145, BE500999, BP212420
    Consensus CDS
    CCDS8928.1
    UniProtKB/Swiss-Prot
    Q9UHF0
    UniProtKB/TrEMBL
    A0A024RB47
    Related
    ENSP00000404056, OTTHUMP00000211122, ENST00000458521, OTTHUMT00000346793
    Conserved Domains (1) summary
    pfam03823
    Location:155
    Neurokinin_B; Neurokinin B

RNA

  1. NR_033654.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY358679, BE500999, BP212420
    Related
    ENST00000357616, OTTHUMT00000346794
  2. NR_135164.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains two alternate internal exons resulting in a longer transcript compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF537114, BE500999, BP212420
  3. NR_135165.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate internal exon resulting in a longer transcript compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF537117, BE500999, BP212420
  4. NR_135166.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon and contains an alternate exon resulting in a longer transcript compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF537120, BE500999, BP212420

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    57009997..57016560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538711.1XP_011537013.1  

    Related
    ENSP00000300108, OTTHUMP00000211129, ENST00000300108, OTTHUMT00000346800
    Conserved Domains (1) summary
    pfam03823
    Location:155
    Neurokinin_B; Neurokinin B

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    57371502..57378066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006667.1: Suppressed sequence

    Description
    NM_001006667.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.