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TAC1 tachykinin, precursor 1 [ Homo sapiens (human) ]

Gene ID: 6863, updated on 6-Jul-2014
Official Symbol
TAC1provided by HGNC
Official Full Name
tachykinin, precursor 1provided by HGNC
Primary source
HGNC:11517
See related
Ensembl:ENSG00000006128; HPRD:08876; MIM:162320; Vega:OTTHUMG00000154069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NK2; NPK; NKNA; TAC2; Hs.2563
Summary
This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
See TAC1 in Epigenomics, MapViewer
Location:
7q21-q22
Exon count :
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 7 NC_000007.14 (97731959..97740472)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (97361271..97369784)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene high mobility group box 3 pseudogene 21 Neighboring gene ACN9 homolog (S. cerevisiae) Neighboring gene ribosomal protein L7a pseudogene 40 Neighboring gene small nuclear ribonucleoprotein polypeptide C pseudogene 9 Neighboring gene asparagine synthetase (glutamine-hydrolyzing)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer.
NHGRI GWA Catalog
Polymorphic markers associated with severe oxaliplatin-induced, chronic peripheral neuropathy in colon cancer patients.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Cannabinoid inhibits HIV-1 gp120-induced calcium influx mediated by substance P in human brain micro vascular endothelial cells (HBMEC) PubMed
env Addition of HIV-1 gp120 to monocyte-derived macrophages (MDM) enhances substance P (SP) expression; this gp120-induced SP expression is abrogated by pretreating the cells with soluble CD4 PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Tachykinin receptors bind tachykinins, organism-specific biosystem (from REACTOME)
    Tachykinin receptors bind tachykinins, organism-specific biosystemTachykinin peptides are one of the largest family of neuropeptides, so named due to their ability to rapidly induce contraction of gut tissue. Tachykinins excite neurons, elicit behavioural responses...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
 
substance P receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
associative learning IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
detection of abiotic stimulus TAS
Traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
insemination TAS
Traceable Author Statement
more info
PubMed 
long-term memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of action potential IEA
Inferred from Electronic Annotation
more info
 
positive regulation of acute inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of corticosterone secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lymphocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of renal sodium excretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of saliva secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stress fiber assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic transmission, GABAergic IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic transmission, cholinergic IEA
Inferred from Electronic Annotation
more info
 
regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
response to hormone IEA
Inferred from Electronic Annotation
more info
 
response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
response to pain IEA
Inferred from Electronic Annotation
more info
 
sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
tachykinin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protachykinin-1
Names
protachykinin-1
PPT
substance K
substance P
neurokinin 1
neurokinin 2
neurokinin A
neuromedin L
tachykinin 2
neuropeptide K
neurokinin alpha
preprotachykinin
neuropeptide gamma
tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003182.2NP_003173.1  protachykinin-1 isoform beta precursor

    See proteins identical to NP_003173.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant beta encodes the full-length form of this gene. It encodes hormones substance P, neurokinin A, as well as the neuropeptide K.
    Source sequence(s)
    AF050655, DN992454, U37529
    Consensus CDS
    CCDS5649.1
    UniProtKB/Swiss-Prot
    P20366
    Related
    ENSP00000321106, OTTHUMP00000204985, ENST00000319273, OTTHUMT00000333696
  2. NM_013996.2NP_054702.1  protachykinin-1 isoform alpha precursor

    See proteins identical to NP_054702.1

    Status: REVIEWED

    Description
    Transcript Variant: As compared to the full-length transcript variant beta, variant alpha lacks exon 6, and therefore does not encode neuropeptide K, neurokinin A, or neuropeptide gamma. This transcript does encode the hormone substance P located on exon 3.
    Source sequence(s)
    AF050656, DN992454, U37529
    Consensus CDS
    CCDS5650.1
    UniProtKB/Swiss-Prot
    P20366
    Related
    ENSP00000289576, OTTHUMP00000204987, ENST00000350485, OTTHUMT00000333698
  3. NM_013997.2NP_054703.1  protachykinin-1 isoform gamma precursor

    See proteins identical to NP_054703.1

    Status: REVIEWED

    Description
    Transcript Variant: As compared to the full-length transcript variant beta, variant gamma lacks exon 4, and therefore does not encode neuropeptide K. This transcript does encode substance P, neurokinin A, and is the only variant that encodes neuropeptide gamma.
    Source sequence(s)
    AF050657, DN992454, U37529
    Consensus CDS
    CCDS5651.1
    UniProtKB/Swiss-Prot
    P20366
    UniProtKB/TrEMBL
    Q9Y494
    Related
    ENSP00000289574, OTTHUMP00000204986, ENST00000346867, OTTHUMT00000333697
  4. NM_013998.2NP_054704.1  protachykinin-1 isoform delta precursor

    See proteins identical to NP_054704.1

    Status: REVIEWED

    Description
    Transcript Variant: As compared to the full-length transcript variant beta, variant delta lacks both exons 4 and 6; therefore, it does not encode neurokinin A, neuropeptide K, or neuropeptide gamma. It does encode the hormone substance P located on exon 3.
    Source sequence(s)
    AF050658, DN992454, U37529
    UniProtKB/Swiss-Prot
    P20366

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000007.14 

    Range
    97731959..97740472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000139.1 

    Range
    91962648..91971157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 

    Range
    97291306..97299818
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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