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    SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) [ Homo sapiens ]

    Gene ID: 6839, updated on 20-May-2012

    Summary

    Official Symbol
    SUV39H1provided by HGNC
    Official Full Name
    suppressor of variegation 3-9 homolog 1 (Drosophila)provided by HGNC
    Primary source
    HGNC:11479
    See related
    Ensembl:ENSG00000101945; HPRD:02221; MIM:300254; Vega:OTTHUMG00000022701
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MG44; KMT1A; SUV39H
    Summary
    This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    Xp11.23
    Sequence :
    Chromosome: X; NC_000023.10 (48555131..48567407)
    See SUV39H1 in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 110 pseudogene Neighboring gene Wiskott-Aldrich syndrome (eczema-thrombocytopenia) Neighboring gene acetyl-CoA acyltransferase 2 pseudogene Neighboring gene glyoxalase domain containing 5

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O43463 Q9C0K0 BCL11B    HPRD  PubMed  
    O43463 P83916 CBX1    HPRD  PubMed  
    O43463 P45973 CBX5    HPRD  PubMed  
    O43463 Q92793 CREBBP    HPRD  PubMed  
    O43463 P26358 DNMT1    HPRD  PubMed  
    O43463 Q9Y6K1 DNMT3A    HPRD  PubMed  
    O43463 Q9UBC3 DNMT3B    HPRD  PubMed  
    O43463 Q09472 EP300    HPRD  PubMed  
    O43463 Q13547 HDAC1    HPRD  PubMed  
    O43463 Q92769 HDAC2    HPRD  PubMed  
    O43463 O15379 HDAC3    HPRD  PubMed  
    O43463 Q9UQL6 HDAC5    HPRD  PubMed  
    O43463 Histone 1, H3A HIST1H3A    HPRD  PubMed  
    O43463 Q16695 HIST3H3    HPRD  PubMed  
    O43463 Q9UIS9 MBD1    HPRD  PubMed  
    O43463 P15172 MYOD1    HPRD  PubMed  
    O43463 P29590 PML    HPRD  PubMed  
    O43463 P06400 RB1    HPRD  PubMed  
    O43463 Q09028 RBBP4    HPRD  PubMed  
    O43463 Q16576 RBBP7    HPRD  PubMed  
    O43463 P28749 RBL1    HPRD  PubMed  
    O43463 Q08999 RBL2    HPRD  PubMed  
    O43463 Q01196 RUNX1    HPRD  PubMed  
    O43463 O95248 SBF1    HPRD  PubMed  
    O43463 Q15797 SMAD1    HPRD  PubMed  
    O43463 Q99717 SMAD5    HPRD  PubMed  
    BioGRID:112706 BioGRID:122343 BCL11B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112706 BioGRID:117070 CABIN1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112706 BioGRID:116151 CBX1    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:112706 BioGRID:114105 CBX4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid 
    BioGRID:112706 BioGRID:117030 CBX5    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:112706 BioGRID:112763 CNTN2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112706 BioGRID:198538 Cbx5    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:112706 BioGRID:107988 DBC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:108123 DNMT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:108125 DNMT3A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112706 BioGRID:108126 DNMT3B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112706 BioGRID:125360 ESCO1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:127605 ESCO2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:113924 GFI1B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112706 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112706 BioGRID:114368 HDAC3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112706 BioGRID:115106 HDAC4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:115083 HDAC9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112706 BioGRID:109319 HDLBP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:113946 HIST1H3A    BioGRID  PubMed Biochemical Activity 
    BioGRID:112706 BioGRID:110322 MBD1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:112706 BioGRID:110358 MDM2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:108423 MECOM    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112706 BioGRID:110368 MECP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:110737 MYOD1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112706 BioGRID:110846 NFATC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:123894 PRAM1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:112706 BioGRID:107108 PRDM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:111849 RARA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112706 BioGRID:111863 RBBP4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112706 BioGRID:111866 RBBP7    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112706 BioGRID:111868 RBL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:111869 RBL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:116954 RRP8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:107309 RUNX1    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:112706 BioGRID:107312 RUNX3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:116067 RUVBL2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112706 BioGRID:112212 SBF1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Synthetic Rescue 
    BioGRID:112706 BioGRID:116983 SIRT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:110265 SMAD5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:112749 TAL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112706 BioGRID:112923 THRA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112706 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112706 BioGRID:104293 epc2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:112706 BioGRID:1205541 tat    BioGRID  PubMed Affinity Capture-Western 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    S-adenosylmethionine-dependent methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone methyltransferase activity (H3-K9 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone-lysine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin organization TAS
    Traceable Author Statement
    more info
    PubMed 
    chromatin silencing at rDNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H3-K9 methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone lysine methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-lysine methylation IEA
    Inferred from Electronic Annotation
    more info
     
    rRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    condensed nuclear chromosome TAS
    Traceable Author Statement
    more info
    PubMed 
    heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase SUV39H1
    Names
    histone-lysine N-methyltransferase SUV39H1
    H3-K9-HMTase 1
    Su(var)3-9 homolog 1
    lysine N-methyltransferase 1A
    histone H3-K9 methyltransferase 1
    position-effect variegation 3-9 homolog
    histone-lysine N-methyltransferase, H3 lysine-9 specific 1
    NP_003164.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012530.1 RefSeqGene

      Range
      5001..17277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003173.2NP_003164.1  histone-lysine N-methyltransferase SUV39H1

      Status: REVIEWED

      Source sequence(s)
      AW327567, BC006238, BG024540
      Consensus CDS
      CCDS14304.1
      UniProtKB/Swiss-Prot
      O43463
      Related
      ENSP00000365877, OTTHUMP00000024298, ENST00000376687, OTTHUMT00000058909
      Conserved Domains (3) summary
      cd00024
      Location:4291
      Blast Score: 122
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cl02566
      Location:243366
      Blast Score: 368
      SET; SET domain
      cl02622
      Location:136235
      Blast Score: 299
      Pre-SET; Pre-SET motif

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      48555131..48567407
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      46217119..46229438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic A58331.1 CAA03483.1
    genomic AF196970.2 (44539..56811) None
    genomic CH471224.1 EAW50756.1
      EAW50757.1
    mRNA AF019968.1 AAB92224.1
    mRNA AF075109.1 None
    mRNA AK223071.1 BAD96791.1
    mRNA AK297566.1 BAG59958.1
    mRNA AK298233.1 BAG60502.1
    mRNA AK299900.1 BAG61742.1
    mRNA AK312547.1 BAG35445.1
    mRNA AW327567.1 None
    mRNA BC006238.2 AAH06238.1
    mRNA BG024540.1 None
    mRNA CR541746.1 CAG46546.1
    mRNA L08238.1 AAA59592.1
    other-genetic DQ892608.2 ABM83534.1
    other-genetic DQ895848.2 ABM86774.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43463.1 GenPept UniProtKB/Swiss-Prot:O43463
    Q14828 GenPept UniProtKB/TrEMBL:Q14828

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