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SURF4 surfeit 4 [ Homo sapiens (human) ]

Gene ID: 6836, updated on 21-Mar-2015
Official Symbol
SURF4provided by HGNC
Official Full Name
surfeit 4provided by HGNC
Primary source
HGNC:HGNC:11476
See related
Ensembl:ENSG00000148248; HPRD:01715; MIM:185660; Vega:OTTHUMG00000020868
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERV29
Summary
This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein that interacts with endoplasmic reticulum-Golgi intermediate compartment proteins. Disruption of this gene results in reduced numbers of endoplasmic reticulum-Golgi intermediate compartment clusters and redistribution of coat protein I to the cytosol. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Orthologs
See SURF4 in MapViewer
Location:
9q34.2
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (133361449..133377949, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (136228325..136244820, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene surfeit 1 Neighboring gene surfeit 2 Neighboring gene serine/threonine kinase-like domain containing 1 Neighboring gene REX4, RNA exonuclease 4 homolog (S. cerevisiae) Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 13 Neighboring gene calcium channel flower domain containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with surfeit 4 (SURF4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22993, MGC102753

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT early endosome to Golgi transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of organelle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT protein exit from endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
surfeit locus protein 4
Names
surfeit locus protein 4
surface 4 integral membrane protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001280788.1NP_001267717.1  surfeit locus protein 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5'-most exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL593848, BM557312, BQ001856, BX647961
    Conserved Domains (1) summary
    pfam02077
    Location:2254
    SURF4; SURF4 family
  2. NM_001280789.1NP_001267718.1  surfeit locus protein 4 isoform 3

    See proteins identical to NP_001267718.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in its 3' coding region, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF078867, BQ001856, BX647961, DC424374
    Consensus CDS
    CCDS65178.1
    UniProtKB/Swiss-Prot
    O15260
    Conserved Domains (1) summary
    pfam02077
    Location:4157
    SURF4; SURF4 family
  3. NM_001280790.1NP_001267719.1  surfeit locus protein 4 isoform 4

    See proteins identical to NP_001267719.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Both variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AK295435, BQ001856, BX647961, DC424374
    Consensus CDS
    CCDS75929.1
    UniProtKB/TrEMBL
    B7Z1G8
    Related
    ENSP00000483216, ENST00000618229
    Conserved Domains (1) summary
    pfam02077
    Location:1226
    SURF4; SURF4 family
  4. NM_001280791.1NP_001267720.1  surfeit locus protein 4 isoform 4

    See proteins identical to NP_001267720.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Both variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AK316480, BQ001856, BX647961, DC424374
    Consensus CDS
    CCDS75929.1
    UniProtKB/TrEMBL
    B7Z1G8
    Related
    ENSP00000481666, ENST00000613129
    Conserved Domains (1) summary
    pfam02077
    Location:1226
    SURF4; SURF4 family
  5. NM_001280792.1NP_001267721.1  surfeit locus protein 4 isoform 5

    See proteins identical to NP_001267721.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (5) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK300004, BQ001856, BX647961, DC424374
    Consensus CDS
    CCDS65177.1
    UniProtKB/Swiss-Prot
    O15260
    Related
    ENSP00000446061, ENST00000545297
    Conserved Domains (1) summary
    pfam02077
    Location:4119
    SURF4; SURF4 family
  6. NM_001280793.1NP_001267722.1  surfeit locus protein 4 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an exon in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    BQ001856, BX647961, DA842525, DC424374
    Conserved Domains (1) summary
    pfam02077
    Location:1152
    SURF4; SURF4 family
  7. NM_033161.3NP_149351.1  surfeit locus protein 4 isoform 1

    See proteins identical to NP_149351.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC018741, BQ001856, BX647961, DC424374
    Consensus CDS
    CCDS6968.1
    UniProtKB/Swiss-Prot
    O15260
    Related
    ENSP00000361057, OTTHUMP00000022476, ENST00000371989, OTTHUMT00000054886
    Conserved Domains (1) summary
    pfam02077
    Location:4269
    SURF4; SURF4 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    133361449..133377949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518943.1XP_011517245.1  

    See proteins identical to XP_011517245.1

    Conserved Domains (1) summary
    pfam02077
    Location:4260
    SURF4; SURF4 family
  2. XM_011518944.1XP_011517246.1  

    See proteins identical to XP_011517246.1

    Conserved Domains (1) summary
    pfam02077
    Location:4260
    SURF4; SURF4 family
  3. XM_011518945.1XP_011517247.1  

    See proteins identical to XP_011517247.1

    Conserved Domains (1) summary
    cl21527
    Location:110206
    DoxX; DoxX

Reference GRCh38.p2 PATCHES

Genomic

  1. NW_009646201.1 Reference GRCh38.p2 PATCHES

    Range
    187543..204043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011548771.1XP_011547073.1  

    See proteins identical to XP_011547073.1

    Conserved Domains (1) summary
    pfam02077
    Location:4260
    SURF4; SURF4 family
  2. XM_011548772.1XP_011547074.1  

    See proteins identical to XP_011547074.1

    Conserved Domains (1) summary
    pfam02077
    Location:4260
    SURF4; SURF4 family
  3. XM_011548773.1XP_011547075.1  

    See proteins identical to XP_011547075.1

    Conserved Domains (1) summary
    cl21527
    Location:110206
    DoxX; DoxX

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    136378468..136394946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)