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    BSG basigin (Ok blood group) [ Homo sapiens ]

    Gene ID: 682, updated on 13-May-2012
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    Summary

    Official Symbol
    BSGprovided by HGNC
    Official Full Name
    basigin (Ok blood group)provided by HGNC
    Primary source
    HGNC:1116
    Locus tag
    UNQ6505/PRO21383
    See related
    Ensembl:ENSG00000172270; HPRD:00176; MIM:109480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    M6; OK; 5F7; TCSF; CD147; EMMPRIN
    Summary
    The protein encoded by this gene is a plasma membrane protein that is important in spermatogenesis, embryo implantation, neural network formation, and tumor progression. The encoded protein is also a member of the immunoglobulin superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    19p13.3
    Sequence :
    Chromosome: 19; NC_000019.9 (571325..583493)
    See BSG in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene cell division cycle 34 homolog (S. cerevisiae) Neighboring gene granzyme M (lymphocyte met-ase 1) Neighboring gene Rho GTPase activating protein 33 pseudogene Neighboring gene hyperpolarization activated cyclic nucleotide-gated potassium channel 2 Neighboring gene polymerase (RNA) mitochondrial (DNA directed)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway. Cui HY, et al. Biochem Biophys Res Commun, 2012 Mar 16. PMID 22366034.
    2. Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrin β1 to modulate malignant properties of hepatoma cells. Li Y, et al. J Biol Chem, 2012 Feb 10. PMID 22130661.
    3. Over-expression of extracellular matrix metalloproteinase inducer in prostate cancer is associated with high risk of prostate-specific antigen relapse after radical prostatectomy. Bi XC, et al. Clin Invest Med, 2011 Dec 1. PMID 22129926.
    4. Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum. Crosnier C, et al. Nature, 2011 Nov 9. PMID 22080952.
    5. A novel functional site of extracellular matrix metalloproteinase inducer (EMMPRIN) that limits the migration of human uterine cervical carcinoma cells. Sato T, et al. Int J Oncol, 2012 Jan. PMID 21994090.

    See all (250) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. the present study provides mutational and functional evidences demonstrating for the first time the functional importance of CD147 dimerization and its direct correlation with invasion and metastasis of tumor cells.
      Title: Dimerization is essential for HAb18G/CD147 promoting tumor invasion via MAPK pathway.
    2. regulates the adhesion of malignant melanoma cells to extracellular matrices and integrin beta1 signaling via the phosphorylation of focal adhesion kinase
      Title: CD147-targeting siRNA inhibits cell-matrix adhesion of human malignant melanoma cells by phosphorylating focal adhesion kinase.
    3. Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrin beta1 to modulate malignant properties of hepatoma cells.
      Title: Extracellular membrane-proximal domain of HAb18G/CD147 binds to metal ion-dependent adhesion site (MIDAS) motif of integrin β1 to modulate malignant properties of hepatoma cells.
    4. CD147 overexpression plays an important role in progression of bladder cancer
      Title: CD147 overexpression is a prognostic factor and a potential therapeutic target in bladder cancer.
    5. Over-expression of extracellular matrix metalloproteinase inducer in prostate cancer is associated with high risk of prostate-specific antigen relapse after radical prostatectomy.
      Title: Over-expression of extracellular matrix metalloproteinase inducer in prostate cancer is associated with high risk of prostate-specific antigen relapse after radical prostatectomy.
    6. Results demonstrate the involvement of CD147 in prostate cancer progression and suggest its potential role as an independent predictor of biochemical recurrence, development of metastasis and reduced overall survival in PCa.
      Title: Expression of CD147 is associated with prostate cancer progression.
    7. basigin is a receptor for PfRh5, a Plasmodium falciparum parasite ligand that is essential for blood stage growth
      Title: Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum.
    8. These findings suggest that CypA, through its interaction with EMMPRIN, contributes to head and neck squamous cell carcinoma tumorigenesis.
      Title: Cyclophilin A-EMMPRIN interaction induces invasion of head and neck squamous cell carcinoma.
    9. Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147.
      Title: Sinomenine reduces invasion and migration ability in fibroblast-like synoviocytes cells co-cultured with activated human monocytic THP-1 cells by inhibiting the expression of MMP-2, MMP-9, CD147.
    10. Data show that a significant increase of MCT2 and MCT4 expression in the cytoplasm of tumour cells and a significant decrease in both MCT1 and CD147 expression in prostate tumour cells was observed when compared to normal tissue.
      Title: Monocarboxylate transporter 4 (MCT4) and CD147 overexpression is associated with poor prognosis in prostate cancer.
    Submit: New GeneRIF Correction See all (205)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Blood group, OK

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env The functional interaction between CD98 and CD147 is involved in the regulation of HIV-1 gp160-mediated cell fusion PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P35613 P35613 BSG    HPRD  PubMed  
    P35613 Q03135 CAV1    HPRD  PubMed  
    P35613 P03956 MMP1    HPRD  PubMed  
    P35613 Q9NR12 PDLIM7    HPRD  PubMed  
    P35613 P62937 PPIA    HPRD  PubMed  
    P35613 Q13356 PPIL2    HPRD  PubMed  
    P35613 P30154 PPP2R1B    HPRD  PubMed  
    P35613 P53985 SLC16A1    HPRD  PubMed  
    P35613 O15427 SLC16A3    HPRD  PubMed  
    P35613 P14672 SLC2A4    HPRD  PubMed  
    BioGRID:107147 BioGRID:117343 ATXN10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107147 BioGRID:198624 Cdk1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107147 BioGRID:114593 HGS    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107147 BioGRID:230105 Haus4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107147 BioGRID:216223 Haus7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107147 BioGRID:110456 MMP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107147 BioGRID:111136 PCK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107147 BioGRID:114682 PDLIM7    BioGRID  PubMed Two-hybrid 
    BioGRID:107147 BioGRID:114070 RANBP3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107147 BioGRID:114180 RFXANK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107147 BioGRID:112454 SLC16A1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107147 BioGRID:114570 SLC16A4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107147 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107147 BioGRID:230642 Tubb4b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107147 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107147 BioGRID:131884 USP50    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107147 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Basigin interactions, organism-specific biosystem (from REACTOME)
      Basigin interactions, organism-specific biosystemBasigin is a widely expressed transmembrane glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of epithelial cells. Basigin is involved in intercellular interaction...
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
      Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
    • Matrix Metalloproteinases, organism-specific biosystem (from WikiPathways)
      Matrix Metalloproteinases, organism-specific biosystemMatrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzi...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Pyruvate metabolism, organism-specific biosystem (from REACTOME)
      Pyruvate metabolism, organism-specific biosystemPyruvate sits at an intersection of key pathways of energy metabolism. It is the end product of glycolysis and the starting point for gluconeogenesis, and can be generated by transamination of alanin...
    • Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystem (from REACTOME)
      Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystemPyruvate metabolism and the citric acid (TCA) cycle together link the processes of energy metabolism in a human cell with one another and with key biosynthetic reactions. Pyruvate, derived from the r...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Syndecan-1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      Syndecan-1-mediated signaling events, organism-specific biosystem
      Syndecan-1-mediated signaling events
    • The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem (from REACTOME)
      The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystemThe metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalen...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    lactate transmembrane transporter activity EXP
    Inferred from Experiment
    more info
    		  
    mannose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sugar binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    decidualization IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryo implantation IEA
    Inferred from Electronic Annotation
    more info
    		  
    lactate transmembrane transport EXP
    Inferred from Experiment
    more info
    		  
    leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
    		  
    pyruvate metabolic process TAS
    Traceable Author Statement
    more info
    		  
    response to cAMP IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to mercury ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to peptide hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    melanosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    basigin
    Names
    basigin
    CD147 antigen
    OK blood group antigen
    collagenase stimulatory factor
    leukocyte activation antigen M6
    extracellular matrix metalloproteinase inducer
    tumor cell-derived collagenase stimulatory factor
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007468.1 RefSeqGene

      Range
      4953..17169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001728.3 → NP_001719.2  basigin isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AY358113, CB153773, GU557064
      Consensus CDS
      CCDS12033.1
      UniProtKB/Swiss-Prot
      P35613
      Related
      ENSP00000333769, ENST00000333511
      Conserved Domains (3) summary
      cd00096
      Location:40 – 114
      Blast Score: 124
      Ig; Immunoglobulin domain
      pfam07686
      Location:215 – 318
      Blast Score: 96
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:219 – 317
      Blast Score: 105
      Ig; Immunoglobulin domain

    2. NM_198589.2 → NP_940991.1  basigin isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AB085790, CB153773, GU557064
      Consensus CDS
      CCDS12034.1
      UniProtKB/Swiss-Prot
      P35613
      UniProtKB/TrEMBL
      Q54A51
      Related
      ENSP00000343809, ENST00000353555
      Conserved Domains (2) summary
      pfam07686
      Location:99 – 202
      Blast Score: 97
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:103 – 201
      Blast Score: 107
      Ig; Immunoglobulin domain

    3. NM_198590.2 → NP_940992.1  basigin isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      DA007913, GU557064
      Conserved Domains (2) summary
      pfam07686
      Location:6 – 109
      Blast Score: 98
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:10 – 108
      Blast Score: 107
      Ig; Immunoglobulin domain

    4. NM_198591.2 → NP_940993.1  basigin isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      DA007913, GU557065
      Consensus CDS
      CCDS12032.1
      Related
      ENSP00000344707, ENST00000346916
      Conserved Domains (2) summary
      pfam07686
      Location:35 – 138
      Blast Score: 97
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:39 – 137
      Blast Score: 106
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      571325..583493
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      342066..354031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC005559.2 AAC33279.1
    genomic AC009005.10 (12592..24760) None
    genomic AF042854.1 AAD10704.1
    genomic AY942196.1 AAX20110.1
    genomic CH471242.1 EAW61180.1
      EAW61181.1
      EAW61182.1
      EAW61183.1
      EAW61184.1
      EAW61185.1
      EAW61186.1
      EAW61187.1
    mRNA AB072923.1 BAB88938.1
    mRNA AB085790.1 BAC76828.1
    mRNA AB091680.1 BAC67168.1
    mRNA AF548371.1 AAN40694.1
    mRNA AK095912.1 None
    mRNA AK296858.1 BAG59422.1
    mRNA AK297880.1 BAG60203.1
    mRNA AK302231.1 BAG63585.1
    mRNA AY358113.1 AAQ88480.1
    mRNA BC009040.2 AAH09040.1
    mRNA BG480530.1 None
    mRNA BI464857.1 None
    mRNA BU501595.1 None
    mRNA CB153773.1 None
    mRNA D28441.1 BAA05807.1
    mRNA D45131.1 BAA08109.1
    mRNA DA007913.1 None
    mRNA GU557064.1 ADD31881.1
    mRNA GU557065.1 ADD31882.1
    mRNA L10240.1 AAA68936.1
    mRNA L20471.1 AAB41120.1
    mRNA M87879.1 AAA91084.1
    mRNA X64364.1 CAA45716.1
    other-genetic JF432780.1 ADZ15997.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35613.2 GenPept UniProtKB/Swiss-Prot:P35613
    Q54A51 GenPept UniProtKB/TrEMBL:Q54A51
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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