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BRS3 bombesin like receptor 3 [ Homo sapiens (human) ]

Gene ID: 680, updated on 26-May-2016
Official Symbol
BRS3provided by HGNC
Official Full Name
bombesin like receptor 3provided by HGNC
Primary source
HGNC:HGNC:1113
See related
Ensembl:ENSG00000102239 HPRD:02116; MIM:300107
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BB3
Summary
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
Orthologs
Location:
Xq26.3
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (136463815..136493774)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (135564521..135575931)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 24 pseudogene 1 Neighboring gene adhesion G protein-coupled receptor G4 Neighboring gene HIV-1 Tat specific factor 1 Neighboring gene vestigial like family member 1 Neighboring gene microRNA 934

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
    Peptide GPCRs, organism-specific biosystem
    Peptide GPCRs
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
bombesin receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adult feeding behavior TAS
Traceable Author Statement
more info
PubMed 
bombesin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process TAS
Traceable Author Statement
more info
PubMed 
regulation of blood pressure TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
bombesin receptor subtype-3
Names
BRS-3
G-protein coupled receptor
bombesin receptor subtype 3
bombesin-like receptor 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001727.1NP_001718.1  bombesin receptor subtype-3

    See identical proteins and their annotated locations for NP_001718.1

    Status: REVIEWED

    Source sequence(s)
    L08893
    Consensus CDS
    CCDS14656.1
    UniProtKB/Swiss-Prot
    P32247
    Related
    ENSP00000359682, OTTHUMP00000024342, ENST00000370648, OTTHUMT00000059005
    Conserved Domains (2) summary
    pfam00001
    Location:71328
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:137347
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    136463815..136493774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262465.2XP_005262522.1  

    See identical proteins and their annotated locations for XP_005262522.1

    UniProtKB/Swiss-Prot
    P32247
    Conserved Domains (2) summary
    pfam00001
    Location:71328
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:137347
    7tm_4; Olfactory receptor

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    135481778..135486251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)