Pold3 polymerase (DNA-directed), delta 3, accessory subunit [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Pold3provided by MGI
Official Full Name: polymerase (DNA-directed), delta 3, accessory subunitprovided by MGI
Primary source: MGI:1915217
See related: Ensembl:ENSMUSG00000030726; Vega:OTTMUSG00000025292
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P66; P68; C85233; 2410142G14Rik

Genomic context

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Location :: 7; 7 F1

Sequence :: Chromosome: 7; NC_000073.6 (100082113..100121500, complement)

See Pold3 in Epigenomics, MapViewer

Chromosome 7 - NC_000073.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:212569	BioGRID:202287	Pola1		BioGRID	PubMed	Co-fractionation
BioGRID:212569	BioGRID:198519	Runx1		BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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Base Excision Repair, organism-specific biosystem (from REACTOME)
Base Excision Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Base excision repair, organism-specific biosystem (from KEGG)
Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
Base excision repair, conserved biosystem (from KEGG)
Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Chromosome Maintenance, organism-specific biosystem (from REACTOME)
Chromosome Maintenance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA Replication, organism-specific biosystem (from WikiPathways)
DNA Replication, organism-specific biosystemDNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original ...
DNA Replication, organism-specific biosystem (from REACTOME)
DNA Replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DNA polymerase delta complex, organism-specific biosystem (from KEGG)
DNA polymerase delta complex, organism-specific biosystemStructural complex; Genetic information processing; DNA polymerase
DNA replication, organism-specific biosystem (from KEGG)
DNA replication, organism-specific biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
DNA replication, conserved biosystem (from KEGG)
DNA replication, conserved biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
DNA strand elongation, organism-specific biosystem (from REACTOME)
DNA strand elongation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Extension of Telomeres, organism-specific biosystem (from REACTOME)
Extension of Telomeres, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gap-filling DNA repair synthesis and ligation in GG-NER, organism-specific biosystem (from REACTOME)
Gap-filling DNA repair synthesis and ligation in GG-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gap-filling DNA repair synthesis and ligation in TC-NER, organism-specific biosystem (from REACTOME)
Gap-filling DNA repair synthesis and ligation in TC-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Global Genomic NER (GG-NER), organism-specific biosystem (from REACTOME)
Global Genomic NER (GG-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Homologous recombination, organism-specific biosystem (from WikiPathways)
Homologous recombination, organism-specific biosystemHomologous recombination, also known as general recombination, is a type of genetic recombination in which nucleotide sequences are exchanged between two similar or identical strands of DNA. Source:...
Homologous recombination, organism-specific biosystem (from KEGG)
Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
Homologous recombination, conserved biosystem (from KEGG)
Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
Lagging Strand Synthesis, organism-specific biosystem (from REACTOME)
Lagging Strand Synthesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Leading Strand Synthesis, organism-specific biosystem (from REACTOME)
Leading Strand Synthesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Mismatch repair, organism-specific biosystem (from KEGG)
Mismatch repair, organism-specific biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
Mismatch repair, conserved biosystem (from KEGG)
Mismatch repair, conserved biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
Nucleotide Excision Repair, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide excision repair, organism-specific biosystem (from KEGG)
Nucleotide excision repair, organism-specific biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
Nucleotide excision repair, conserved biosystem (from KEGG)
Nucleotide excision repair, conserved biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
Polymerase switching, organism-specific biosystem (from REACTOME)
Polymerase switching, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Polymerase switching on the C-strand of the telomere, organism-specific biosystem (from REACTOME)
Polymerase switching on the C-strand of the telomere, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Processive synthesis on the C-strand of the telomere, organism-specific biosystem (from REACTOME)
Processive synthesis on the C-strand of the telomere, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Processive synthesis on the lagging strand, organism-specific biosystem (from REACTOME)
Processive synthesis on the lagging strand, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Purine metabolism, organism-specific biosystem (from KEGG)
Purine metabolism, organism-specific biosystem
Purine metabolism
Purine metabolism, organism-specific biosystem (from WikiPathways)
Purine metabolism, organism-specific biosystem
Purine metabolism
Purine metabolism, conserved biosystem (from KEGG)
Purine metabolism, conserved biosystem
Purine metabolism
Pyrimidine metabolism, organism-specific biosystem (from KEGG)
Pyrimidine metabolism, organism-specific biosystem
Pyrimidine metabolism
Pyrimidine metabolism, conserved biosystem (from KEGG)
Pyrimidine metabolism, conserved biosystem
Pyrimidine metabolism
Removal of DNA patch containing abasic residue, organism-specific biosystem (from REACTOME)
Removal of DNA patch containing abasic residue, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Removal of the Flap Intermediate, organism-specific biosystem (from REACTOME)
Removal of the Flap Intermediate, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Removal of the Flap Intermediate from the C-strand, organism-specific biosystem (from REACTOME)
Removal of the Flap Intermediate from the C-strand, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Repair synthesis for gap-filling by DNA polymerase in TC-NER, organism-specific biosystem (from REACTOME)
Repair synthesis for gap-filling by DNA polymerase in TC-NER, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Repair synthesis of patch ~27-30 bases long by DNA polymerase, organism-specific biosystem (from REACTOME)
Repair synthesis of patch ~27-30 bases long by DNA polymerase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway, organism-specific biosystem (from REACTOME)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Resolution of Abasic Sites (AP sites), organism-specific biosystem (from REACTOME)
Resolution of Abasic Sites (AP sites), organism-specific biosystemcomputationally inferred pathway (not manually curated)
S Phase, organism-specific biosystem (from REACTOME)
S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis of DNA, organism-specific biosystem (from REACTOME)
Synthesis of DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Telomere C-strand (Lagging Strand) Synthesis, organism-specific biosystem (from REACTOME)
Telomere C-strand (Lagging Strand) Synthesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Telomere Maintenance, organism-specific biosystem (from REACTOME)
Telomere Maintenance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcription-coupled NER (TC-NER), organism-specific biosystem (from REACTOME)
Transcription-coupled NER (TC-NER), organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Markers

RH127155 (e-PCR)
- UniSTS:208160

RH137658 (e-PCR)
- UniSTS:219745

RH128123 (e-PCR)
- UniSTS:211431

Homology

Homologs of the Pold3 gene: The Pold3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, M.oryzae, N.crassa, A.thaliana, and rice.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA replication	IEA Inferred from Electronic Annotation more info
DNA-dependent DNA replication	ISO Inferred from Sequence Orthology more info
nucleotide-excision repair, DNA gap filling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
mitochondrion	ISO Inferred from Sequence Orthology more info
nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA polymerase delta subunit 3

Names: DNA polymerase delta subunit 3; GC12; DNA polymerase delta subunit p66; polymerase (DNA directed), delta 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133692.2 → NP_598453.1 DNA polymerase delta subunit 3

Status: PROVISIONAL

Source sequence(s)

AK031778

Consensus CDS

CCDS21493.1

UniProtKB/TrEMBL

Q8BH76

Related

ENSMUSP00000032969, OTTMUSP00000030660, ENSMUST00000032969, OTTMUST00000062244

Conserved Domains (1) summary

pfam09507
Location:19 – 461
Blast Score: 685

CDC27; DNA polymerase subunit Cdc27

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000073.6 Reference GRCm38.p1 C57BL/6J

Range

100082113..100121500, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000029.1 Alternate Mm_Celera

Range

100414045..100453506, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01064783.1 (11970..19845)	None
genomic	AAHY01064784.1	None
genomic	AC161205.3 (163180..202567)	None
genomic	CH466531.1	EDL16420.1	mixed
		EDL16421.1	mixed
		EDL16422.1	mixed
mRNA	AF294329.1	AAG45967.1	BALB/c
mRNA	AK010805.1	None	C57BL/6J
mRNA	AK012386.1	None	C57BL/6J
mRNA	AK031778.1	BAC27544.1	C57BL/6J
mRNA	AK088385.1	BAC40320.1	NOD
mRNA	AK162240.1	BAE36810.1	C57BL/6J
mRNA	AK168179.1	BAE40139.1	BALB/c
mRNA	AK180448.1	None
mRNA	AK189114.1	None
mRNA	BC055325.1	AAH55325.1	C57BL/6