STK11 serine/threonine kinase 11 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: STK11provided by HGNC
Official Full Name: serine/threonine kinase 11provided by HGNC
Primary source: HGNC:11389
See related: Ensembl:ENSG00000118046; HPRD:03740; MIM:602216; Vega:OTTHUMG00000180118
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PJS; LKB1; hLKB1
Summary: This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 19p13.3

Sequence :: Chromosome: 19; NC_000019.9 (1205798..1228434)

See STK11 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that LKB1 acts as a tumour suppressor in most sporadic cases of clear cell renal cell carcinoma and that underexpression of LKB1 is a common event in the disease
Title: Underexpression of tumour suppressor LKB1 in clear cell renal cell carcinoma is common and confers growth advantage in vitro and in vivo.
these results suggest that Artemis functions as a positive regulator of AMPK signaling by stabilizing the LKB1-AMPK complex.
Title: The nuclear protein Artemis promotes AMPK activation by stabilizing the LKB1-AMPK complex.
Results suggest that LKB1 expression may be implicated in resistance to chemoradiotherapy (CRT), therefore contributing to tumor relapse in patients with locally advanced rectal cancer treated with preoperative CRT.
Title: Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy.
CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss.
Title: The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss.
Post-translational modification of serine/threonine kinase LKB1 via Adduction of the Reactive Lipid Species 4-Hydroxy-trans-2-nonenal (HNE) at lysine residue 97 directly inhibits kinase activity.
Title: Post-translational modification of serine/threonine kinase LKB1 via Adduction of the Reactive Lipid Species 4-Hydroxy-trans-2-nonenal (HNE) at lysine residue 97 directly inhibits kinase activity.
the orphan nuclear receptor Nur77 binds and sequesters LKB1 in the nucleus, thereby attenuating AMPK activation
Title: The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK.
Two missense mutations of the STK11 gene associated with Peutz-Jeghers syndrome.
Title: Two variants in STK11 gene in Chinese patients with Peutz-Jeghers syndrome.
Data suggest that macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT) act cooperatively to inhibit steady-state phosphorylation and activation of AMPK in LKB1 wild type and LKB1 mutant non-small cell lung carcinomas cells.
Title: Negative regulation of AMP-activated protein kinase (AMPK) activity by macrophage migration inhibitory factor (MIF) family members in non-small cell lung carcinomas.
catabolic glucocorticoid hormones and high intracellular AMP levels cooperate in inducing FOXO3 transcription and in activating the corresponding protein
Title: FOXO3 is a glucocorticoid receptor target and regulates LKB1 and its own expression based on cellular AMP levels via a positive autoregulatory loop.
One mutation in LKB1 was a previously unreported 30-base-pair deletion in exon 4, and the other was an intron mutation that affected splicing. The results support the hypothesis that mutation of the LKB1 gene is a cause of Peutz-Jeghers syndrome.
Title: One novel deletion and one splicing mutation of the LKB1 gene in two Chinese patients with Peutz-Jeghers syndrome.

Submit: New GeneRIF Correction See all (180)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Peutz-Jeghers syndrome (PJS) is characterized by the association of gastrointestinal polyposis and mucocutaneous pigmentation. Peutz-Jeghers-type hamartomatous polyps are most common in the small intestine (in order of prevalence: in the jejunum, ileum, and duodenum) but can also occur in the stomach, large bowel, and nasal passages. Gastrointestinal polyps can result in chronic bleeding and anemia and cause recurrent obstruction and intussusception requiring repeated laparotomy and bowel resection. Mucocutaneous hyperpigmentation presents in childhood as dark blue to dark brown macules around the mouth, eyes, and nostrils, in the perianal area, and on the buccal mucosa. Hyperpigmented macules on the fingers are common. The macules may fade in puberty and adulthood. Individuals with Peutz-Jeghers syndrome are at increased risk for a wide variety of epithelial malignancies (colorectal, gastric, pancreatic, breast, and ovarian cancers). Females are at risk for sex cord tumors with annular tubules (SCTAT), a benign neoplasm of the ovaries, and adenoma malignum of the cervix, a rare aggressive cancer. Males occasionally develop calcifying Sertoli cell tumors of the testes, which secrete estrogen and can lead to gynecomastia.

Diagnosis Testing

The diagnosis of Peutz-Jeghers syndrome is based on clinical findings. In individuals with a clinical diagnosis of PJS, molecular genetic testing of STK11 (LKB1) reveals disease-causing mutations in nearly all individuals who have a positive family history and approximately 90% of individuals who have no family history of PJS. Such testing is available clinically.

Genetic Counseling

Peutz-Jeghers syndrome is inherited in an autosomal dominant manner. About 50% of affected individuals have an affected parent and about 50% have no family history of PJS; the proportion of cases caused by de novo gene mutations is unknown as the frequency of subtle signs of the disorder in parents has not been thoroughly evaluated and molecular genetic data are insufficient. The risk to the offspring of an individual with a pathogenic STK11 mutation is 50%. Prenatal testing for pregnancies at increased risk is possible if the disease-causing mutation in the family is known

References

PMID: 20301443

NHGRI GWAS Catalog

Genome-wide association study of Alzheimer's disease with psychotic symptoms.

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_000446.1	NP_113605.2	MARK4	BIND	PubMed	LKB1 phosphorylates MARK4.
NP_000446.1	NP_006243.2	PRKAA2	BIND	PubMed	LKB1 interacts with AMPK-alpha.
NP_000446.1	NP_000446.1	STK11	BIND	PubMed	LKB1 autophosphorylates itself.
NP_000446.1	NP_061041.2	STRADB	BIND	PubMed	LKB1 phosphorylates PAPK.
Q15831	Q13315	ATM	HPRD	PubMed
Q15831	Q9Y376	CAB39	HPRD	PubMed
Q15831	Q16543	CDC37	HPRD	PubMed
Q15831	Q9P0L2	MARK1	HPRD	PubMed
Q15831	Q7KZI7	MARK2	HPRD	PubMed
Q15831	Q96L34	MARK4	HPRD	PubMed
Q15831	Q9Y3A3	MOB4	HPRD	PubMed
Q15831	Q8TEW0	PARD3	HPRD	PubMed
Q15831	P54646	PRKAA2	HPRD	PubMed
Q15831	P17612	PRKACA	HPRD	PubMed
Q15831	P60484	PTEN	HPRD	PubMed
Q15831	P51812	RPS6KA3	HPRD	PubMed
Q15831	O75582	RPS6KA5	HPRD	PubMed
Q15831	P23443	RPS6KB1	HPRD	PubMed
Q15831	P51532	SMARCA4	HPRD	PubMed
Q15831	Q9NRH2	SNRK	HPRD	PubMed
Q15831	Q15831	STK11	HPRD	PubMed
Q15831	LKB1 interacting protein 1	STK11IP	HPRD	PubMed
Q15831	Protein kinase LYK5	STRADA	HPRD	PubMed
Q15831	Q9C0K7	STRADB	HPRD	PubMed
Q15831	TNFAIP3 interacting protein 2	TNIP2	HPRD	PubMed
Q15831	P04637	TP53	HPRD	PubMed
BioGRID:112670	BioGRID:107587	AP2M1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112670	BioGRID:106848	APP	BioGRID	PubMed	Reconstituted Complex
BioGRID:112670	BioGRID:198131	Ap2m1	BioGRID	PubMed	Two-hybrid
BioGRID:112670	BioGRID:119696	CAB39	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:112670	BioGRID:123552	CAB39L	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112670	BioGRID:116312	CDC37	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:112670	BioGRID:108286	EIF2B1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112670	BioGRID:229070	Eif2b1	BioGRID	PubMed	Two-hybrid
BioGRID:112670	BioGRID:108579	FKBP5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112670	BioGRID:109187	GSK3B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112670	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Affinity Capture-Luminescence; Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:112670	BioGRID:109535	HSPA1A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112670	BioGRID:114873	KIF23	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112670	BioGRID:110175	LIMS1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112670	BioGRID:108326	MARK2	BioGRID	PubMed	Biochemical Activity
BioGRID:112670	BioGRID:121760	MARK4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112670	BioGRID:111549	PRKAA1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:112670	BioGRID:122783	RPAP3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112670	BioGRID:127260	SIK1	BioGRID	PubMed	Biochemical Activity
BioGRID:112670	BioGRID:112481	SMARCA4	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:112670	BioGRID:112483	SMARCC1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112670	BioGRID:120211	SNRK	BioGRID	PubMed	Biochemical Activity
BioGRID:112670	BioGRID:125352	STK11IP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112670	BioGRID:124934	STRADA	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
BioGRID:112670	BioGRID:120668	STRADB	BioGRID	PubMed	Affinity Capture-MS; Biochemical Activity
BioGRID:112670	BioGRID:115563	STUB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112670	BioGRID:122573	TNIP2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:112670	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112670	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112670	BioGRID:113170	UBE2D2	BioGRID	PubMed	Biochemical Activity
BioGRID:112670	BioGRID:113866	USP11	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112670	BioGRID:121649	WDR48	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystem (from REACTOME)
AMPK inhibits chREBP transcriptional activation activity, organism-specific biosystemAMP-activated protein kinase (AMPK) is a sensor of cellular energy levels. A high cellular ratio of AMP:ATP triggers the phosphorylation and activation of AMPK. Activated AMPK in turn phosphorylates ...
AMPK signaling, organism-specific biosystem (from WikiPathways)
AMPK signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
Adipocytokine signaling pathway, organism-specific biosystem (from KEGG)
Adipocytokine signaling pathway, organism-specific biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
Adipocytokine signaling pathway, conserved biosystem (from KEGG)
Adipocytokine signaling pathway, conserved biosystemIncreased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. Leptin is an important regulator of energy intake and...
Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem (from REACTOME)
Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystemUpon formation of a trimeric LKB1:STRAD:MO25 complex, LKB1 phosphorylates and activates AMPK. If the AMP:ATP ratio rises, this activation is maintained and AMPK activates the TSC complex by phosphory...
IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
IRS-mediated signalling, organism-specific biosystem (from REACTOME)
IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
IRS-related events, organism-specific biosystem (from REACTOME)
IRS-related events, organism-specific biosystemIRS is one of the mediators of insulin signalling events. It is activated by phosphorylation and triggers a cascade of events involving PI3K, SOS, RAF and the MAP kinases. The proteins mentioned unde...
IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
IRS-related events triggered by IGF1R, organism-specific biosystemThe phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et a...
Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
Integration of energy metabolism, organism-specific biosystem (from REACTOME)
Integration of energy metabolism, organism-specific biosystemMany hormones that affect individual physiological processes including the regulation of appetite, absorption, transport, and oxidation of foodstuffs influence energy metabolism pathways. While insul...
LKB1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
LKB1 signaling events, organism-specific biosystem
LKB1 signaling events
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
PI3K Cascade, organism-specific biosystem (from REACTOME)
PI3K Cascade, organism-specific biosystem
PI3K Cascade
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PKB-mediated events, organism-specific biosystem (from REACTOME)
PKB-mediated events, organism-specific biosystemPKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.
Regulation of AMPK activity via LKB1, organism-specific biosystem (from REACTOME)
Regulation of AMPK activity via LKB1, organism-specific biosystemLKB1 forms a complex with STRAD and MO25 thereby attaining a higher activity towards its substrates belonging to the subfamily of AMPK like kinases. LKB1:STRAD:MO25 complex phosphorylates AMPK consta...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
mTOR signaling pathway, organism-specific biosystem (from KEGG)
mTOR signaling pathway, organism-specific biosystem
mTOR signaling pathway
mTOR signaling pathway, conserved biosystem (from KEGG)
mTOR signaling pathway, conserved biosystem
mTOR signaling pathway
mTOR signalling, organism-specific biosystem (from REACTOME)
mTOR signalling, organism-specific biosystem
mTOR signalling

General gene information

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Markers

REU1905 (e-PCR)
- UniSTS:257089

RH104368 (e-PCR)
- UniSTS:98693

Stk11 (e-PCR), detects polymorphism
- UniSTS:546518

Genotypes

See STK11 SNP Geneview Report
See STK11 SNP Genotype Report
See STK11 SNP Variation Viewer Report

Homology

Homologs of the STK11 gene: The STK11 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, fruit fly, and C.elegans.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
LRR domain binding	IEA Inferred from Electronic Annotation more info
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
p53 binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein complex binding	IEA Inferred from Electronic Annotation more info
protein kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
Golgi localization	IEA Inferred from Electronic Annotation more info
anoikis	IMP Inferred from Mutant Phenotype more info	PubMed
autophagy	IEA Inferred from Electronic Annotation more info
axonogenesis	IEA Inferred from Electronic Annotation more info
canonical Wnt receptor signaling pathway	IEA Inferred from Electronic Annotation more info
cell cycle arrest	IDA Inferred from Direct Assay more info	PubMed
cell cycle arrest	TAS Traceable Author Statement more info
energy reserve metabolic process	TAS Traceable Author Statement more info
establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
insulin receptor signaling pathway	TAS Traceable Author Statement more info
intrinsic apoptotic signaling pathway by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of epithelial cell proliferation involved in prostate gland development	IEA Inferred from Electronic Annotation more info
positive regulation of axonogenesis	IEA Inferred from Electronic Annotation more info
positive regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
positive regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein heterooligomerization	IEA Inferred from Electronic Annotation more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of Wnt receptor signaling pathway	IEA Inferred from Electronic Annotation more info
regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
regulation of fatty acid biosynthetic process	TAS Traceable Author Statement more info
regulation of protein kinase B signaling cascade	IEA Inferred from Electronic Annotation more info
response to DNA damage stimulus	IEA Inferred from Electronic Annotation more info
response to glucagon stimulus	IEA Inferred from Electronic Annotation more info
response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info
response to lipid	IEA Inferred from Electronic Annotation more info
small molecule metabolic process	TAS Traceable Author Statement more info
spermatid development	IEA Inferred from Electronic Annotation more info
tissue homeostasis	IEA Inferred from Electronic Annotation more info
vasculature development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	ISS Inferred from Sequence or Structural Similarity more info
cytosol	TAS Traceable Author Statement more info
membrane	ISS Inferred from Sequence or Structural Similarity more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info
protein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase STK11

Names: serine/threonine-protein kinase STK11; liver kinase B1; polarization-related protein LKB1; renal carcinoma antigen NY-REN-19; serine/threonine-protein kinase 11; serine/threonine-protein kinase LKB1

NP_000446.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007460.2 RefSeqGene

Range

21393..44029

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_319

mRNA and Protein(s)

NM_000455.4 → NP_000446.1 serine/threonine-protein kinase STK11

Status: REVIEWED

Source sequence(s)

BC007981, BC019334, BM993274, BQ222023, BU174122, BU739451

Consensus CDS

CCDS45896.1

UniProtKB/Swiss-Prot

Q15831

Related

ENSP00000324856, OTTHUMP00000263382, ENST00000326873, OTTHUMT00000449839

Conserved Domains (2) summary

cd00180
Location:55 – 306
Blast Score: 424

PKc; Catalytic domain of Protein Kinases

smart00220
Location:49 – 309
Blast Score: 598

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p10 Primary Assembly

Range

1205798..1228434

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

981572..1004116

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018930.1 Alternate CHM1_1.0

Range

1133837..1156404

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01002630.1	None
genomic	ABBA01002631.1	None
genomic	AC004221.2	AAF97257.1
genomic	AC011544.6 (26191..45903)	None
genomic	AF032986.1	AAB97833.1
genomic	AF055327.1	AAC15742.1
genomic	AMYH01009230.1 (8833..11532)	None
genomic	AMYH01009231.1	None
genomic	CH471139.2	EAW69538.1
		EAW69539.1
		EAW69540.1
mRNA	AB209553.1	BAD92790.1
mRNA	AF035625.1	AAC39527.1
mRNA	AF217978.1	AAG17221.1
mRNA	AJ844634.2	CAH59749.2
mRNA	AK128518.1	None
mRNA	AK314858.1	BAG37374.1
mRNA	BC007981.2	AAH07981.1
mRNA	BC019334.1	AAH19334.1
mRNA	BM993274.1	None
mRNA	BQ222023.1	None
mRNA	BU174122.1	None
mRNA	BU739451.1	None
mRNA	EF644172.1	ABR45718.1
mRNA	U63333.1	AAB05809.1
other-genetic	DQ893232.2	ABM84158.1
other-genetic	DQ896561.2	ABM87560.1