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Plpp3 phospholipid phosphatase 3 [ Mus musculus (house mouse) ]

Gene ID: 67916, updated on 28-May-2016
Official Symbol
Plpp3provided by MGI
Official Full Name
phospholipid phosphatase 3provided by MGI
Primary source
MGI:MGI:1915166
See related
Ensembl:ENSMUSG00000028517 Vega:OTTMUSG00000008128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lpp3; Ppab2b; Ppap2b; AV025606; D4Bwg0538e; D4Bwg1535e; 1110003O22Rik; 2610002D05Rik
Orthologs
Location:
4 C6; 4 49.18 cM
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 4 NC_000070.6 (105157347..105232767)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (104829952..104905372)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 36893 Neighboring gene predicted gene, 29838 Neighboring gene predicted gene, 40217 Neighboring gene predicted gene 12722

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidate phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
sphingosine-1-phosphate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
Bergmann glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
canonical Wnt signaling pathway involved in positive regulation of wound healing ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
PubMed 
homotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
phospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of sphingolipid mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
single organismal cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
phospholipid phosphatase 3
Names
PAP-2b
PAP2-beta
PAP2b
lipid phosphate phosphohydrolase 3
phosphatidate phosphohydrolase type 2b
phosphatidic acid phosphatase 2b
phosphatidic acid phosphatase type 2B
NP_542122.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080555.2NP_542122.1  phospholipid phosphatase 3

    See identical proteins and their annotated locations for NP_542122.1

    Status: VALIDATED

    Source sequence(s)
    AK159136, AK160056, AV018880, BY129827
    Consensus CDS
    CCDS18417.1
    UniProtKB/Swiss-Prot
    Q99JY8
    Related
    ENSMUSP00000065719, OTTMUSP00000008487, ENSMUST00000064139, OTTMUST00000018472
    Conserved Domains (2) summary
    COG0671
    Location:189274
    PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
    cd03384
    Location:126272
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p3 C57BL/6J

    Range
    105157347..105232767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000026.1 Alternate Mm_Celera

    Range
    103508199..103583768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)